Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats

Đurašević, Siniša; Nikolić, Gorana; Todorović, Ana; Drakulić, Dunja; Pejić, Snežana; Martinović, Vesna; Mitić-Ćulafić, Dragana; Milić, Dragana; Kop, Tatjana J.; Jasnić, Nebojša; Đorđević, Jelena; Todorović, Zoran

doi:10.1016/j.fct.2020.111302

Cited by 13 publications

(8 citation statements)

References 90 publications

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“…Glycaemia slightly increased only in the TAA+F2 group, which is another sign of the harmful effect of a high dose of fullerene. Previously we reported similar effects of a higher C60 dose, hypothesizing that they are caused by its pro-oxidant behaviour [35]. It is known that in an aqueous milieu, such as blood and/or cytoplasm, C60 becomes prone to self-aggregation [36] and, consequently, to pro-oxidant action [37,38].…”

Section: Resultsmentioning

confidence: 74%

Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes

et al. 2021

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Thioacetamide (TAA) is widely used to study liver toxicity accompanied by oxidative stress, inflammation, cell necrosis, fibrosis, cholestasis, and hepatocellular carcinoma. As an efficient free radical’s scavenger, C60 fullerene is considered a potential liver-protective agent in chemically-induced liver injury. In the present work, we examined the hepatoprotective effects of two C60 doses dissolved in virgin olive oil against TAA-induced hepatotoxicity in rats. We showed that TAA-induced increase in liver oxidative stress, judged by the changes in the activities of SOD, CAT, GPx, GR, GST, the content of GSH and 4-HNE, and expression of HO-1, MnSOD, and CuZnSOD, was more effectively ameliorated with a lower C60 dose. Improvement in liver antioxidative status caused by C60 was accompanied by a decrease in liver HMGB1 expression and an increase in nuclear Nrf2/NF-κB p65 ratio, suggesting a reduction in inflammation, necrosis and fibrosis. These results were in accordance with liver histology analysis, liver comet assay, and changes in serum levels of ALT, AST, and AP. The changes observed in gut microbiome support detrimental effects of TAA and hepatoprotective effects of low C60 dose. Less protective effects of a higher C60 dose could be a consequence of its enhanced aggregation and related pro-oxidant role.

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Section: Resultsmentioning

confidence: 74%

Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes

et al. 2021

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“…On the other hand, 10 weeks repeated oral exposure to multi-walled carbon nanotubes (MWCNTs; 4 or- 40 mg/week) did not cause changes in the composition of GM in mice ( Christophersen et al., 2016 ). Other carbon-based NMs that have been studied include graphene, which had greater effects on Gram-positive bacteria than Gram-negative bacteria in mice ( Xie et al., 2016 ), as well as fullerenol ( Li et al., 2018a ), fullerenes ( Đurašević et al., 2020 ), nanofibrils (nanocellulose) ( Khare et al., 2020 ), Chitin nanofibers (CNFs) ( Azuma et al., 2015 ) and Cu-loaded chitosan NPs ( Han et al., 2010 ). The results of these studies are summarized in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

“…(2018a) . Fullerenes (size not stated) Rats Dietary 0 and 5 mg/kg b.w day, 12 weeks Shift in GM structure towards the bacteria that ameliorate lipid homeostasis 2 Đurašević et al. (2020) .…”

Section: Resultsmentioning

confidence: 99%

A systematic review on the effects of nanomaterials on gut microbiota

Utembe

Tlotleng

Kamng’ona

2022

Current Research in Microbial Sciences

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“…However, the hydrophobic nature of fullerenes can be a problem for biological applications because they tend to aggregate and accumulate in organs such as liver, heart, and adrenal glands, potentially leading to toxicity [ 192 ]. For this reason, fullerenes are often functionalized with hydrophilic groups or molecules to increase their dispersibility in water.…”

Section: Applications Of Cnms For Targeted Drug Deliverymentioning

confidence: 99%

Carbon Graphitization: Towards Greener Alternatives to Develop Nanomaterials for Targeted Drug Delivery

Marin

Marchesan

2022

Biomedicines

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Carbon nanomaterials have attracted great interest for their unique physico-chemical properties for various applications, including medicine and, in particular, drug delivery, to solve the most challenging unmet clinical needs. Graphitization is a process that has become very popular for their production or modification. However, traditional conditions are energy-demanding; thus, recent efforts have been devoted to the development of greener routes that require lower temperatures or that use waste or byproducts as a carbon source in order to be more sustainable. In this concise review, we analyze the progress made in the last five years in this area, as well as in their development as drug delivery agents, focusing on active targeting, and conclude with a perspective on the future of the field.

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Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats

Cited by 13 publications

References 90 publications

Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes

Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes

A systematic review on the effects of nanomaterials on gut microbiota

Carbon Graphitization: Towards Greener Alternatives to Develop Nanomaterials for Targeted Drug Delivery

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