Effects of furosemide on renal haemodynamics and proximal tubular sodium reabsorption in conscious rats

Christensen, Sten; Petersen, Jørgen S.

doi:10.1111/j.1476-5381.1988.tb11653.x

Cited by 27 publications

(16 citation statements)

References 9 publications

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“…The administration of FUR caused a reduction in the GFR, due to the predominantly renal vasoconstrictor effects of the diuretic which have been previously reported in rats [9,[30][31][32][33][34]. The lower efficiency of FUR in decreasing the GFR in female rats might be due to the higher circulating levels of PGE 2 previously reported in females [26].…”

Section: Discussionmentioning

confidence: 73%

Gender-Related Differences in the Pharmacodynamics of Furosemide in Rats

Brandoni

Villar²,

Torres³

2004

Pharmacology

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The possibility of gender differences in the relationship between dose and efficacy of drugs has historically been limited. The aim of the present study was to evaluate the influence of sex on the pharmacodynamics of furosemide (FUR) in adult Wistar rats. Conventional renal clearance studies were performed in the absence and in the presence of a FUR dose necessary to produce identical urine excretion rates of FUR in both sexes. Fractional excretions of sodium, potassium, and water were similar in male and female rats in the absence of FUR. Natriuretic, kaliuretic, and diuretic responses to FUR, when expressed in fractional terms, were significantly increased in female rats. Diuretic, natriuretic, and kaliuretic efficiencies of FUR were also higher in female rats as compared with males. This might be explained by the lower abundance of the Na-K-2Cl cotransporter observed in homogenates from the medullae of female kidneys as compared with male ones.

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Section: Discussionmentioning

confidence: 73%

Gender-Related Differences in the Pharmacodynamics of Furosemide in Rats

Brandoni

Villar²,

Torres³

2004

Pharmacology

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“…These effects may therefore add to the change in ADC, since renal vasoconstriction may be associated with a decrease in the intravascular volume. Furthermore, volume depletion has effects on renal hemodynamics, including a sustained decrease in glomerular filtration rate and the blood perfusion of the kidney (4,14,16,18,43), which has been shown to depend linearly on RBF (35). Furosemide has in addition been demonstrated to block the tubuloglomerular feedback response, followed by significant decreases in renal interstitial concentrations of ATP (26).…”

Section: Discussionmentioning

confidence: 97%

Furosemide increases water content in renal tissue

Pedersen¹,

Vajda²,

Stødkilde‐Jørgensen³

et al. 2007

American Journal of Physiology-Renal Physiology

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The present study was designed to evaluate the short-term effects of intravenous administration of furosemide on key functions in the kidney cortex and the outer and inner medulla of rats by using magnetic resonance imaging (MRI). Renal tissue water content, renal tissue oxygenation (in relation to the magnetic resonance spin-spin relaxation rate), the apparent diffusion coefficient (ADC) of water, and volume of renal blood flow were measured. Furosemide administration resulted in an increased water content in all regions of the kidney. In parallel with this, we found a significant reduction in ADC in the cortex (2.7 +/- 0.1 x 10(-3) to 2.3 +/- 0.1 x 10(-3) mm(2)/s; P < 0.01) and in the outer medulla (2.3 +/- 0.1 x 10(-3) to 2.0 +/- 0.1 x 10(-3) mm(2)/s; P < 0.01), indicating that the intra- to extracellular volume fraction of water increased in response to furosemide administration. Furosemide also decreased the blood oxygenation in the cortex (49.1 +/- 2.9 to 40.9 +/- 2.0 s(-1); P < 0.01), outer medulla (41.9 +/- 2.8 to 33.2 +/- 1.6 s(-1); P < 0.01) and in the inner medulla (37.1 +/- 2.9 to 26.7 +/- 1.8 s(-1); P < 0.01), indicating an increased amount of oxygenated Hb in the renal tissue. Moreover, renal blood flow decreased in response to furosemide (6.9 +/- 0.2 to 4.4 +/- 0.2 ml/min; P < 0.001). In conclusion, furosemide administration was associated with increased renal water content, an increase in the intra- to extracellular volume fraction of water, an increased oxygen tension, and a decrease in the renal blood flow. Thus MRI provides an integrated evaluation of changes in renal function, leading to decreased renal water and solute reabsorption in response to furosemide, and, in addition, MRI provides an alternative tool to monitor noninvasively changes at the cellular level.

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“…Water loading causes higher blood flow into glomeruli, higher tubular flow in tubules, higher transtubular water reabsorption, and higher venous flow. Furosemide inhibits water reabsorption in the descending limb of the medullary loop of Henle (23), which increases intratubular flow and/or volume throughout the nephron (24), usually without much increase in vascular flow (25,26). There is evidence of tubular dilation with either flow challenge (24,27).…”

Section: Volunteer Datamentioning

confidence: 99%

Intravoxel Incoherent Motion and Diffusion-Tensor Imaging in Renal Tissue under Hydration and Furosemide Flow Challenges

Sigmund¹,

Vivier²,

Sui³

et al. 2012

Radiology

195

210

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Purpose:To assess the reproducibility and the distribution of intravoxel incoherent motion (IVIM) and diffusion-tensor (DT) imaging parameters in healthy renal cortex and medulla at baseline and after hydration or furosemide challenges. Materials and Methods:Using an institutional review board-approved HIPAAcompliant protocol with written informed consent, IVIM and DT imaging were performed at 3 T in 10 volunteers before and after water loading or furosemide administration. /msec, P = .0094). Urine output correlated with cortical ADC with furosemide (r = 0.7, P = .034) and with medullary l 1 (r = 0.83, P = .0418), l 2 (r = 0.85, P = .0301), and MD (r = 0.82, P = .045) with hydration. Conclusion:Diffusion MR metrics are sensitive to flow changes in kidney induced by diuretic challenges. The results of this study suggest that vascular flow, tubular dilation, water reabsorption, and intratubular flow all play important roles in diffusion-weighted imaging contrast.q RSNA, 2012

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Effects of furosemide on renal haemodynamics and proximal tubular sodium reabsorption in conscious rats

Cited by 27 publications

References 9 publications

Gender-Related Differences in the Pharmacodynamics of Furosemide in Rats

Gender-Related Differences in the Pharmacodynamics of Furosemide in Rats

Furosemide increases water content in renal tissue

Intravoxel Incoherent Motion and Diffusion-Tensor Imaging in Renal Tissue under Hydration and Furosemide Flow Challenges

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