Effects of furosemide on the tubular reabsorption of nitrates in anesthetized dogs

Rahman, Matlubur; Kimura, Shoji; Yoneyama, Hiroto; Kosaka, Hiroaki; Nishiyama, Akira; Fukui, Toshiki; Abe, Youichi

doi:10.1016/s0014-2999(01)01357-7

Cited by 24 publications

(14 citation statements)

References 13 publications

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“…Although the origin of urinary NO x remains a matter of controversy, urinary NO x reflects at least in part the renal production. 17,18 In concert, these observations are consistent with the formulation that renal NO contributes importantly to the reduction in proteinuria, and may indicate renal protective action of NO in this circumstance. In addition to the beneficial effect of NO in renal disease, several lines of studies by our laboratory 8 and others 7 demonstrate implication of the haemodynamic contribution of these agents to renal protection.…”

Section: Discussionsupporting

confidence: 83%

Distinct time courses of renal protective action of angiotensin receptor antagonists and ACE inhibitors in chronic renal disease

2003

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Although the angiotensin receptor antagonist (ARB) shares the angiotensin-II-blocking activity with the angiotensin-converting enzyme inhibitor (ACE-I), pharmacological mechanisms of action of these agents differ. We evaluated the temporal profiles of action of ACE-I and ARB on urinary protein excretion and nitrate/ nitrate (NO x ) excretion in hypertensive (140 and/or 90 mmHg) patients with chronic renal disease (serum creatinineo265 (range, 44-265) lmol/l or creatinine clearance430 (range, 30-121) ml/min). Patients with mild (o1 g/day; range, 0.4-1.0) and moderate proteinuria (41 g/day; range, 1.1-6.9) were randomly assigned to ACE-I-and ARB-treated groups, and were treated with ACE-I (trandolapril or perindopril) or ARB(losartan or candesartan) for 48 weeks. In all groups, treatment with ACE-I or ARB decreased blood pressure to the same level, but had no effect on creatinine clearance. In patients with mild proteinuria, neither ACE-I nor ARB altered urinary protein excretion. In patients with moderate proteinuria, ACE-I caused 44 7 6% reduction in proteinuria (from 2.7 7 0.5 to 1.5 7 0.4 g/day, n ¼ 14) at 12 weeks, and this beneficial effect persisted throughout the protocol (48 weeks, 1.2 7 0.2 g/day). In contrast, ARB did not produce a significant decrease in proteinuria at 12 weeks (23 7 8%, n ¼ 13), but a 41 7 6% reduction in proteinuria was observed at 48 weeks. Similarly, although early (12 weeks) increases in urinary NO x excretion were observed with ACE-I (from 257 7 70 to 1111 7 160 lmol/day) and ARB (from 280 7 82 to 723 7 86 lmol/day), the ARB-induced increase in NO x excretion was smaller than that by ACE-I (Po0.05). In conclusion, although both ACE-I and ARB reduce blood pressure similarly, the effect of these agents on proteinuria differs in chronic renal disease with moderate proteinuria. Relatively early onset of the proteinuriareducing effect was observed with ACE-I, which paralleled the increase in urinary NO x excretion. Conversely, ARB decreased proteinuria and increased urinary NO x excretion gradually. These time course-dependent changes in proteinuria and urinary NO x may reflect the pharmacological property of ACE-I and ARB, with regard to the action on bradykinin.

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Section: Discussionsupporting

confidence: 83%

Distinct time courses of renal protective action of angiotensin receptor antagonists and ACE inhibitors in chronic renal disease

2003

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“…It is also possible that the use of different nitrate salts may have resulted in differences in renal clearance of the anion. The mechanism by which nitrate is reabsorbed following glomerular filtration is unclear; however, it has been suggested that sodium and nitrate may be reabsorbed at the same site, intimating cotransport (41). Administration of NaNO 3 in dogs resulted in reduced NO x reabsorption and greater NO x excretion (42).…”

Section: Discussionmentioning

confidence: 99%

Antiinflammatory actions of inorganic nitrate stabilize the atherosclerotic plaque

Khambata

Ghosh

Rathod

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Reduced bioavailable nitric oxide (NO) plays a key role in the enhanced leukocyte recruitment reflective of systemic inflammation thought to precede and underlie atherosclerotic plaque formation and instability. Recent evidence demonstrates that inorganic nitrate (NO 3 − ) through sequential chemical reduction in vivo provides a source of NO that exerts beneficial effects upon the cardiovascular system, including reductions in inflammatory responses. We tested whether the antiinflammatory effects of inorganic nitrate might prove useful in ameliorating atherosclerotic disease in Apolipoprotein (Apo)E knockout (KO) mice. We show that dietary nitrate treatment, although having no effect upon total plaque area, caused a reduction in macrophage accumulation and an elevation in smooth muscle accumulation within atherosclerotic plaques of ApoE KO mice, suggesting plaque stabilization. We also show that in nitratefed mice there is reduced systemic leukocyte rolling and adherence, circulating neutrophil numbers, neutrophil CD11b expression, and myeloperoxidase activity compared with wild-type littermates. Moreover, we show in both the ApoE KO mice and using an acute model of inflammation that this effect upon neutrophils results in consequent reductions in inflammatory monocyte expression that is associated with elevations of the antiinflammatory cytokine interleukin (IL)-10. In summary, we demonstrate that inorganic nitrate suppresses acute and chronic inflammation by targeting neutrophil recruitment and that this effect, at least in part, results in consequent reductions in the inflammatory status of atheromatous plaque, and suggest that this effect may have clinical utility in the prophylaxis of inflammatory atherosclerotic disease.

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“…3 and 4). Although there is still controversy regarding the origin of urinary NOx, urinary NOx reflects, at least in part, the renal production (28,29). Since renal NO is assumed to protect against the progression of renal injury (30,31), the enhanced renal NO, in addition to ANG blockade, teleologically would contribute to the reduction in proteinuria.…”

Section: Fig 4 Effects Of Angiotensin Converting Enzyme Inhibitors mentioning

confidence: 99%

Differing Anti-Proteinuric Action of Candesartan and Losartan in Chronic Renal Disease

et al. 2003

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Effects of furosemide on the tubular reabsorption of nitrates in anesthetized dogs

Cited by 24 publications

References 13 publications

Distinct time courses of renal protective action of angiotensin receptor antagonists and ACE inhibitors in chronic renal disease

Distinct time courses of renal protective action of angiotensin receptor antagonists and ACE inhibitors in chronic renal disease

Antiinflammatory actions of inorganic nitrate stabilize the atherosclerotic plaque

Differing Anti-Proteinuric Action of Candesartan and Losartan in Chronic Renal Disease

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