Effects of Gaba Derivatives on Anxious and Compulsive Behavior in Offspring of Rats with Experimental Preeclampsia

Muzyko, E. A.; Tkacheva, G A; Перфилова, В. Н.; Matvienko, L S; Науменко, Л. В.; Васильева, О. С.; Tyurenkov, I. N.

doi:10.1007/s10517-020-04731-x

Cited by 2 publications

(3 citation statements)

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“…The improvement in the psychoemotional state of offspring of rats with EP treated with the studied compounds can probably be explained by the fact that GABA derivatives have nootropic, neuro-and endothelioprotective, antihypoxic and anxiolytic effects as was shown in the previous studies (Tyurenkov et al 2014a;Muzyko et al 2020). Besides, the substances of this pharmacological group improve the processes of respiration and oxidative phosphorylation by reducing energy deficiency of neurons in hypoxia.…”

Section: Resultssupporting

confidence: 55%

“…The experimental study by Trofimova et al (2010) showed that intrauterine intermittent hypoxia triggered a decrease in motor activity of rat offspring and an increase in their anxiety. Our previous studies also indicated the negative impact of EP on the psycho-emotional state of offspring (Tyurenkov et al 2014a;Muzyko et al 2020).…”

Section: Resultsmentioning

confidence: 64%

“…In this regard, derivatives of gamma-aminobutyric acid (GABA) which produce neuroprotective and nootropic effects have anti-hypoxic and anxiolytic effects, and improve memory and mental performance are of interest (Tyurenkov et al 2014a;Muzyko et al 2020).…”

Section: Introductionmentioning

confidence: 99%

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The effect of early and late pharmacological correction with GABA derivatives of psychoemotional state of offspring of rats with experimental preeclampsia

Muzyko¹,

Перфилова²,

Suvorin³

et al. 2020

RRP

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Introduction: Preeclampsia is a serious complication of pregnancy, which increases the risk of anxiety disorders and depression in children at different stages of ontogenesis. Materials and methods: The psychoemotional state of 70-day-old offspring of rats with experimental preeclampsia (EP) was studied after pharmacological correction from the 40th to 70th day of offspring life with GABA derivatives – succicard (22 mg/kg), salifen (7.5 mg/kg), phenibut (25 mg/kg) and comparison drug pantogam (50 mg) – in the Open field test, the Elevated plus maze test, and the Marble burying test. The above mentioned tests, together with the Porsolt test, were performed at the age of 18 months. At the second step, the offspring received succicard (44 mg/kg), salifen (15 mg/kg), phenibut (50 mg/kg) and pantogam (100 mg) from the 24th to 25th month of life. After that, the animals were tested. Results and discussion: The EP progeny had an increased level of anxiety and depression, as well as obsessive-compulsive disorder. Early GABA derivatives exposure limited anxiety and depression in the animals aged 70 days and 18 months, with salifen limiting compulsive behavior. Late GABA derivatives “treatment” exerted anti-compulsive and antidepressant effects, with phenibut having a greater degree of anxiolytic activity. Succicard, salifen and phenibut were comparable or superior to pantogam in terms of effectiveness. Conclusion: EP has a negative effect on the psychoemotional state of offspring. Early and late pharmacological correction with derivatives of GABA, such as succicard, salifen and phenibut, reduced anxiety, manifestations of obsessive-compulsive disorder, and depression in offspring of the rats with EP pregnancy.

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Section: Resultssupporting

confidence: 55%