Effects of Gadolinium Contrast Agent Administration on Automatic Brain Tissue Classification of Patients with Multiple Sclerosis

Warntjes, J. B. M.; Tisell, Anders; Landtblom, Anne‐Marie; Lundberg, Peter

doi:10.3174/ajnr.a3890

Cited by 19 publications

(18 citation statements)

References 34 publications

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“…As an example, the ICV could be defined as either the intracranial cavity measured directly [42] or as the sum of the volumes of GM, WM and CSF [43]. Only studies having included the complete intracranial space in the assessment of ICV were included in the aggregated statistical calculations.…”

Section: Resultsmentioning

confidence: 99%

Brain Parenchymal Fraction in Healthy Adults—A Systematic Review of the Literature

2017

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Brain atrophy is an important feature of many neurodegenerative disorders. It can be described in terms of change in the brain parenchymal fraction (BPF). In order to interpret the BPF in disease, knowledge on the BPF in healthy individuals is required. The aim of this study was to establish a normal range of values for the BPF of healthy individuals via a systematic review of the literature. The databases PubMed and Scopus were searched and 95 articles, including a total of 9269 individuals, were identified including the required data. We present values of BPF from healthy individuals stratified by age and post-processing method. The mean BPF correlated with mean age and there were significant differences in age-adjusted mean BPF between methods. This study contributes to increased knowledge about BPF in healthy individuals, which may assist in the interpretation of BPF in the setting of disease. We highlight the differences between post-processing methods and the need for a consensus gold standard.

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Section: Resultsmentioning

confidence: 99%

Brain Parenchymal Fraction in Healthy Adults—A Systematic Review of the Literature

2017

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“…Future technical effort should try to eliminate the need for this gap in SyMRI and should try to make high-resolution 3D acquisitions possible, which is increasingly important in MS studies. 30,31 Previous studies of the effects of intravenous gadoliniumbased contrast media on the volumetric output of SyMRI indicate that it is important to consistently acquire synthetic MR imaging either pre-or postcontrast for comparability 32 ; these findings are the reason we chose to focus on nonenhanced acquisitions in this study. Future studies will be able to clarify how synthetic MR imaging could be implemented as a postcontrast examination and in a longitudinal fashion in MS.…”

Section: Discussionmentioning

confidence: 99%

Clinical Feasibility of Synthetic MRI in Multiple Sclerosis: A Diagnostic and Volumetric Validation Study

Granberg¹,

Uppman

Hashim³

et al. 2016

AJNR Am J Neuroradiol

125

111

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“…GdCl 3 is an MRI contrast agent which is widely used at present and whose safety has been evaluated (27,28). We found that high dosages of GdCl 3 markedly suppressed the proliferation of macrophages.…”

Section: Discussionmentioning

confidence: 98%

GdCl3 suppresses the malignant potential of hepatocellular carcinoma by inhibiting the expression of CD206 in tumor-associated macrophages

Zhu

Jiang

et al. 2015

Oncology Reports

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Abstract. In the present study, we aimed to ascertain whether there is a correlation between CD206 expression in tumor associated-macrophages (TAMs) and the prognosis of primary hepatocellular carcinomas (HCC) and we investigated the effect of GdCl 3 on HCC. The expression of CD206 in HCC tumor tissues and peri-carcinoma tissues was measured using an array for liver tissues. The effects of GdCl 3 on CD206 expression were examined in stimulated RAW264.7 cells. Target gene expression was evaluated by RT-PCR, western blotting and immunohistochemistry. The Transwell system was used to assess the invasiveness of HCC cells. Finally, we established a mouse model for HCC using N-nitrosodiethylamine (DEN) to determine the effect of GdCl 3 on HCC. Liver tissue array analysis revealed that CD206 was highly expressed in the HCC tissues compared to the level in peri-carcinoma tissue. We found that GdCl 3 suppressed the expression of CD206 in the M2 macrophage phenotype of stimulated RAW264.7 cells with an IC 10 value of 0.07 µg/µl. In addition, GdCl 3 also induced cell apoptosis in the RAW264.7 cells. Addition of GdCl 3 into the culture medium of RAW264.7 cells markedly reduced the invasive ability of Hepa1-6 cells compared to the control cells. Accordingly, GdCl 3 treatment increased the expression of the epithelial-mesenchymal transition (EMT)-related protein E-cadherin while expression of N-cadherin, TWIST and Snail was reduced in IL-4-stimulated cells. Moreover, GdCl 3 treatment inhibited HCC progression in DEN-induced HCC mice, possibly by downregulating CD206. Our findings indicate that CD206 is a potential biomarker for predicting HCC prognosis and that GdCl 3 suppresses HCC progression by downregulating the expression of CD206 in TAMs.

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Effects of Gadolinium Contrast Agent Administration on Automatic Brain Tissue Classification of Patients with Multiple Sclerosis

Cited by 19 publications

References 34 publications

Brain Parenchymal Fraction in Healthy Adults—A Systematic Review of the Literature

Brain Parenchymal Fraction in Healthy Adults—A Systematic Review of the Literature

Clinical Feasibility of Synthetic MRI in Multiple Sclerosis: A Diagnostic and Volumetric Validation Study

GdCl3 suppresses the malignant potential of hepatocellular carcinoma by inhibiting the expression of CD206 in tumor-associated macrophages

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