Effects of Gamisoyo-San Decoction, a Traditional Chinese Medicine, on Gastrointestinal Motility

Abstract

Background: Gamisoyo-San decoction (GSS), a traditional Chinese medicine, has been used to treat various gastrointestinal (GI) symptoms and diseases such as functional dyspepsia. The purpose of this study was to investigate the effect of GSS on GI motility functions in mice. Methods: Percent intestinal transit rate (ITR%) and gastric emptying (GE) values were measured using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). Results: In normal mice, GSS (0.01–1 g/kg) induced higher GE values than non-treated controls. Also, GSS could increase GE in loperamide-induced and cisplatin-induced GE delay models. In addition, GSS increased ITR% in a dose-dependent manner. Loperamide decreased ITR% and GSS recovered this loperamide-induced decrease in ITR%. To examine the effect of GSS on GMD, we used acetic acid (AA)-induced and streptozotocin (STZ)-induced mouse GMD models. The AA mouse model showed a significant decrease in ITR%. However, intragastric treatment with GSS significantly recovered this inhibition. Furthermore, STZ-induced diabetic mice showed a significant reduction in ITR%, which was also significantly inhibited by GSS. Conclusion: These results demonstrate that GSS can modulate bowel activity and that it could be used as a gastroprokinetic agent in the treatment of GI motility diseases.

An Herbal Formulation of Jiawei Xiaoyao for the Treatment of Functional Dyspepsia: A Multicenter, Randomized, Placebo-Controlled, Clinical Trial

“…Traditional herbal medicine has been listed as a second-line treatment in the guidelines of the Japanese Society of Gastroenterology, although with weak recommendations ( 6 ). The Jiawei Xiaoyao (JX) pill, which contains the same components as Gamisoyo-San in Japan ( 13 ), is an herbal medicine that is broadly used throughout China, Japan, and Korea to promote Qi and blood as well as to nourish the spleen based on the framework of traditional medicine theory; it also relieves symptoms such as epigastric discomfort ( 14 ). The 6-g JX pill is composed of the following raw herbs: Paeonia lactiflora Pall., 1.8 g; Atractylodes macrocephala Koidz., 1.8 g; Mentha canadensis L., 0.36 g; Bupleurum falcatum L., 1.8 g; Angelica sinensis (Oliv.)…”

Involvement of MT2 receptors in protective effects of melatonin against cisplatin-induced gastrointestinal damage in mice

“…In the present study, the CP dose employed was as reported by Viana-Cardoso et al (2011) and Shin et al (2018); this dose sufficiently induced GE delay by dysautonomia. The dose of MLT was based on previous studies indicating its protective effects (Kasimay et al, 2005;Konturek et al, 2007;Barberino et al, 2017;Kim et al, 2019).…”

68Ga-NOTA PET imaging for gastric emptying assessment in mice

“…Although lots of TCMs showed efficacy for the treatment of gastrointestinal motility disorders, only a few of the underlying mechanisms of these treatments have been explored [49]. Among them, many studies chose to measure the changes in GE during treatment to demonstrate their efficacy [50][51][52]. The feasibility and availability of PET for GE measurement established in this study would provide a powerful tool for these pharmacological studies.…”