Effects of .GAMMA.-oryzanol on gastric lesions and small intestinal propulsive activity in mice.

Ichimaru, Yasuyuki; Moriyama, Minehiro; Ichimaru, M; Gomita, Yutaka

doi:10.1254/fpj.84.537

Cited by 11 publications

(6 citation statements)

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“…were effective in a acetylsalicylic acid ulcer model [13], and cimet idine (at 50 and 100 mg/kg, p.o.) was effec tive in indomethacin-induced ulcer but not in a reserpine ulcer model [14], These results and our previous observations of anti-ulcer effects of diazepam, oxazolam [ 10], sulpiride [17], gamma-oryzanol and atropine [18] in the same method support the applicability of the communication box method for evalua tion of the effect of anti-ulcer drugs. When gastric mucosal lesions were made to the same degree in 'responders' and 'senders', cetrax ate, cimetidine and gefarnate, which are con sidered to act peripherally, showed a stronger suppressive effect in the 'responders' than in the 'senders' as mentioned above.…”

Section: Discussionsupporting

confidence: 82%

A New Screening Method for Anti-Ulcer Agents: Psychological Stress Produced by Intraspecies Emotional Communication

Ichimaru¹,

Gomita

1987

Pharmacology

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Psychological stress produced by intraspecies emotional communication in a communication box was studied to see whether it could be applied to a new screening method for anti-ulcer agents. There were two groups of mice, the ‘sender’ mice that received electrical foot shocks and showed emotional responses such as piloerection, abnormal squealing and jumping, and the ‘responder’ mice that were affected by the sender’s emotional responses without foot shock. The gastric lesions (erosions) produced by conditioned emotional stimuli were observed in both groups. The effects of the anti-ulcer drugs cetraxate, cimetidine and gefarnate were examined. In ‘senders’, the gastric lesions were significantly suppressed by the administration of cetraxate at a dose of 200 mg/kg (p.o.) or cimetidine at doses of 30 and 100 mg/kg (p.o.). The gastric lesions in ‘responders’ were significantly suppressed by two administrations of cetraxate at doses of 100 and 200 mg/kg (p.o.), cimetidine at doses of 10–100 mg/kg (p.o.) or gefarnate at a dose of 200 mg/kg (p.o.). The gastric lesions of ‘responders’ were more sensitive to anti-ulcer drugs. The present results indicate that the gastric erosions of ‘responders’ are useful for the evaluation of anti-ulcer agents.

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Section: Discussionsupporting

confidence: 82%

A New Screening Method for Anti-Ulcer Agents: Psychological Stress Produced by Intraspecies Emotional Communication

Ichimaru¹,

Gomita

1987

Pharmacology

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“…In addition, the incidence of gastric lesions induced by REM sleep deprivation was also reduced by a single administration of g-oryzanol at 100 and 200 mg/kg and oxazolam at 5 mg/kg. Moreover, the facilitation of small intestinal propulsive activity induced by convulsive electroshock in responder-mice was suppressed by g-oryzanol at 100 and 200 mg/kg and atropine at 10 mg/kg (Ichimaru et al, 1984). This modulatory effect on gastrointestinal motility was also observed in the dog (Mizonishi and Semba, 1980).…”

Section: Gastroenterological Studiesmentioning

confidence: 72%

“…One of the most investigated properties of g-oryzanol is its antiulcerogenic property Ichimaru et al, 1984). Different studies have been carried out on rat models to evaluate which pharmacological mechanism is mainly involved in g-oryzanol's antiulcerogenic property.…”

Section: Gastroenterological Studiesmentioning

confidence: 99%

Rice Bran Oil and γ‐Oryzanol in the Treatment of Hyperlipoproteinaemias and Other Conditions

Cicero

Gaddi

2001

Phytotherapy Research

241

119

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Diet is the first (and sometimes the only) therapeutic approach to hyperlipoproteinaemias. Rice bran oil and its main components (unsaturated fatty acids, triterpene alcohols, phytosterols, tocotrienols, alpha-tocopherol) have demonstrated an ability to improve the plasma lipid pattern of rodents, rabbits, non-human primates and humans, reducing total plasma cholesterol and triglyceride concentration and increasing the high density lipoprotein cholesterol level. Other potential properties of rice bran oil and gamma-oryzanol, studied both in vitro and in animal models, include modulation of pituitary secretion, inhibition of gastric acid secretion, antioxidant action and inhibition of platelet aggregation. This paper reviews the available data on the pharmacology and toxicology of rice bran oil and its main components with particular attention to those studies relating to plasma lipid altering effects.

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“…The preventive action of GO has been demonstrated in various types of experimental ulcers: water immersion stress ulcers (Itaya and Kiyonaga, ), conditioned emotional stimuli (communication box method) and rapid eye movement (REM) sleep deprivation ulcers (Ichimaru et al., ), vagal stimulants‐insulin or 2‐deoxy‐D‐glucose‐induced ulcers (Mizuta and Itaya, ). Moreover, GO administration inhibited tetragastrin‐stimulated gastrin secretion (Mizuta et al., ) which contrasts to the slight effects on ulcers induced by pylorus‐ligation, stress‐atropine as well as histamine‐ and carbachol‐stimulated acid secretion (Mizuta et al., ).…”

Section: Other Effects Of Gamma‐oryzanolmentioning

confidence: 99%

“…Likewise, pre‐treatment with 100 mg/kg BW GO s.c. for 5 days depressed gastric secretion stimulated both by vagal stimulants: insulin and 2 deoxy‐D‐glucose, but the potency was less than that with 10 mg/kg BW s.c. atropine (Mizuta and Itaya, ). In addition, modulatory effect on gastrointestinal motility was observed in dogs (Mizonishi and Semba, ) and the facilitation of small intestinal propulsion induced by convulsive electroshock in responder‐mice was suppressed by GO at 100 and 200 mg/kg BW and atropine at 10 mg/kg BW (Ichimaru et al., ).…”

Section: Other Effects Of Gamma‐oryzanolmentioning

confidence: 99%

Investigation of nutriactive phytochemical – gamma‐oryzanol in experimental animal models

Szcześniak

Ostaszewski

Ciecierska

et al. 2015

Animal Physiology Nutrition

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SummaryGamma-oryzanol (GO) is an abundant dietary antioxidant that is considered to have beneficial effects in cardiovascular disease, cancer and diabetes. Other potential properties of GO include inhibition of gastric acid secretion and decreased post-exercise muscle fatigue. GO is a unique mixture of triterpene alcohol and sterol ferulates present in rice bran oil, a byproduct of rice processing. GO has been studied by many researchers over the last three decades. In particular, the utility of GO supplementation has been documented in numerous animal models. A large variety of species was examined, and various experimental methodologies and targets were applied. The aim of this study was to summarize the body of research on GO supplementation in animals and to examine possible mechanisms of GO action. Furthermore, while the safety of GO supplementation in animals has been well documented, studies demonstrating pharmacokinetics, pharmacodynamics and efficiency are less clear. The observed differences in these findings are also discussed.

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Effects of .GAMMA.-oryzanol on gastric lesions and small intestinal propulsive activity in mice.

Cited by 11 publications

References 0 publications

A New Screening Method for Anti-Ulcer Agents: Psychological Stress Produced by Intraspecies Emotional Communication

A New Screening Method for Anti-Ulcer Agents: Psychological Stress Produced by Intraspecies Emotional Communication

Rice Bran Oil and γ‐Oryzanol in the Treatment of Hyperlipoproteinaemias and Other Conditions

Investigation of nutriactive phytochemical – gamma‐oryzanol in experimental animal models

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