Effects of Garlic (Ailium sativum) on Chemically Induced Hepatocarcinogenesis in Normal and Hypercholesterolaemic Wistar Rats

Samaranayake, M.D.P.

doi:10.31357/fmesmph.2000.00121

Cited by 1 publication

(2 citation statements)

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“…Equal amounts of the mixture (~2 ml) were given to all the rats, except the negative control group, once a day orally throughout the experiment. The rats with blood cholesterol levels greater than 120 mg/dl were considered as hypercholesterolemic (Samaranayaka, 2000) and were chosen for the study.…”

Section: Induction Of Cholesterolmentioning

confidence: 99%

“…Although P. reticulates (Santoshkumar et al, 2012) and P. emblica (Samaranayaka, 2000) reported to have exhibited anti-hypercholesterolemic activity, there were hardly any scientific reports are available on the antihypercholesterolemic activity including dose dependence of P. maderaspatensis L. Further, there was lack of studies in acute toxicity and dose dependency of methanolic extract of P. maderaspatensis L. in anti-hypercholesterolemic activity. The present study is the first investigation on the methanolic extract of P. madaraspatentis L. plant on the diet induced hypercholectrolemic rats.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Phyllanthus maderaspatensis L. crude methanolic extract on diet induced hypercholesterolemia in Wistar albino rats (Mus norvegicus albinus)

Dissanayaka¹,

Nilakarawasam²,

Somaratne³

et al. 2019

Ceylon J. Sci.

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Present experiment was aimed to assess the diet induced hypocholesterolemic activity of crude methanolic extracts of Phyllanthus maderaspatensis L. on Wistar rats. The crude whole plant methanolic extract was administered orally at the dosage of 2000 mg/kg body weight per day, to diet induced hypercholesterolemic Wistar albino rats for 14 days to assess the acute toxicity and hypercholesterolemic activity. Lower concentrations were used since no toxicity found during the acute toxicity experiment. Dosages of Methanolic extracts of 400mg, 800 mg and 1200 mg/ kg body weight per day were orally administered to rats for 42 days whilst total cholesterol, triglyceride, were studied. Hardly any acute toxicity signs and liver toxicity were observed with the extract of 2000 mg/kg. The same concentration indicated a reduction of total cholesterol and triglyceride during 14 days. The groups treated with three lower doses of extract exhibited dose dependent negative response with total cholesterol and triglyceride. Results indicated capability of the crude methanolic extract of P. maderaspatensis L. in total cholesterol and triglyceride in diet induced hypercholestrolemic Wistar rats.

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Section: Induction Of Cholesterolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%