Effects of garlic extract on lipid profile in patients with coronary artery disease: A systematic review and meta‐analysis of randomised clinical trials

Kheirmandparizi, Maryam; Keshavarz, Pedram; Nowrouzi-Sohrabi, Peyman; Hosseini-Bensenjan, Mahnaz; Rezaei, Shahla; Kashani, Seyyed Mohammad Amin; Zeidi, Nazanin; Tabrizi, Reza; Alkamel, Abdolhamid

doi:10.1111/ijcp.14974

Cited by 10 publications

(3 citation statements)

References 38 publications

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“…A meta-analysis of randomized controlled trials involving 768 patients with type 2 diabetes mellitus indicated improvement of FPG, plasma fructosamine, glycated hemoglobin, TG, TC, HDL-C, and LDL-C levels following garlic supplementation [40]. However, in another meta-analysis, garlic ameliorated serum TC, but not TG, HDL-C, or LDL-C, in patients with coronary artery disease [41]. Differences in the studied population, study duration, and kind of intervention could potentially explain these conflicting findings.…”

Section: Discussionmentioning

confidence: 99%

Influence of Garlic on the Glycemic Control and Lipid Profile in Animals with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

et al. 2023

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Nonalcoholic fatty liver disease is the hepatic sign of metabolic syndrome. Here, we aimed to assess the effects of garlic and its major components on fasting plasma glucose, fasting insulin, and lipid profile levels in animal models of nonalcoholic fatty liver disease. A systematic search in PubMed, Scopus, ProQuest, and Web of Science was performed. After the screening process and data extraction, the pooled effect sizes were estimated using a random-effect model and stated as standardized mean differences and a 95% confidence interval. Out of 839 reports, 22 articles were included in the present study. The pooled results revealed that garlic and its components significantly decreased fasting plasma glucose (standardized mean difference: − 0.77, 95% confidence interval: − 1.42 to − 0.12, I2 : 58.85%), fasting insulin (standardized mean difference: − 1.88, 95% confidence interval: − 3.07 to − 0.69, I2 : 70.42%), serum triglyceride (standardized mean difference: − 1.01, 95% confidence interval: − 1.43 to − 0.59, I2 : 61.41%), cholesterol (standardized mean difference: − 1.00, 95% confidence interval: − 1.39 to − 0.60, I2 : 52.12%), and low-density lipoprotein cholesterol (standardized mean difference: − 0.98, 95% CI: − 1.63 to − 0.32, I2 : 71.58%) and increased high-density lipoprotein cholesterol (standardized mean difference: 1.05, 95% confidence interval: 0.52 to 1.58, I2 : 59.39%) levels. The type of animal, nonalcoholic fatty liver disease induction model, kind and duration of intervention, study model, and risk of bias were detected as possible sources of heterogeneity across studies. We conclude that garlic and its major components have a favorable impact on glycemic control and lipid profile in diet-induced nonalcoholic fatty liver disease animal models.

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Section: Discussionmentioning

confidence: 99%

Influence of Garlic on the Glycemic Control and Lipid Profile in Animals with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

et al. 2023

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“…Garlic-derived polysulfides, particularly S-allylcysteine, also reported to regulate endothelial NO, leading to vasodilation and blood pressure reduction [ 46 ]. Meta-analyses have confirmed the effectiveness of aged garlic extract in lowering blood pressure and improving lipid profiles [ 47 ]. Additionally, various antioxidant compounds have demonstrated antihypertensive effects by targeting distinct pathways, including the modulation of the renin-angiotensin system, vasodilation, and sodium excretion [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Potential antihypertensive activity of novel peptides from green basil leaves

Prangthip¹,

Panbangred²,

Reamtong³

2023

BMC Complement Med Ther

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Hypertension is among the risk factors of death globally. Novel antihypertensive peptides are alternative choices of antihypertensive assistance. This study aimed to discover novel antihypertensive peptides from green basil leaves. Two bioactive peptides with high angiotensin-converting enzyme inhibition (Asp-Leu-Ser-Ser-Ala-Pro; peptide 1) and antioxidant (Asp-Ser-Val-Ser-Ala-Ser-Pro; peptide 2) activities were gavaged to male Wistar rats induced with NG-nitro-l-arginine methyl-ester (L-NAME). L-NAME-treated rats (HT) had decreased body weights and levels of nitrite and nitrate, which are metabolites of nitric oxide. The levels of their glucose and liver function indicators increased as compared to normal rats. HT rats receiving antihypertensive drugs (HTD) showed higher low-density lipoprotein and low-density lipoprotein/high-density lipoprotein levels than HT rats. Peptide 1 seems to benefit the rat lipid profiles, liver functions, antioxidant, nitrite, nitrate, and angiotensin II peptide levels but not peptide 2. In conclusion, our findings indicate the antihypertensive potential related to vasodilation of peptides from green basil leaves. Graphical Abstract

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“…Maryam (2021) telah mengemukakan bahwa suplementasi bawang putih dapat menyebabkan penurunan total kolesterol, tetapi tidak mempengaruhi kadar TG, HDL, dan LDL (Kheirmandparizi, 2021). Bawang putih mengandung allicin dan beberapa antioksidan seperti vitamin C, Germanium dan senyawa yang berkaitan dengan sulfur.…”

Section: Pembahasanunclassified

Efek suplementasi kombinasi bawang putih, jahe merah, dan beras ragi merah (BJR-22) terhadap kadar kolesterol LDL pasien stroke dengan dislipidemia

Sutoyo,

Aisy,

Rinaldi

et al. 2023

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Background: Stroke is the second leading cause of death worldwide, a significant contributor to disability, and the leading cause of stroke prevention by controlling risk factors. Dyslipidemia is a high risk of plaque buildup in the cell wall. An alternative search must be performed to prevent recurrent stroke events and to improve survival without disability. Nutraceuticals such as garlic (Allium sativum), red ginger (Zingiber officinale Roxb. var. rubrum Rosc.), and red yeast rice (Monascus purpureus) contain active compounds that inhibit HMG-CoA activity and limit the rate of cholesterol synthesis.Objectives: To analyze the effect of red ginger, garlic, and red yeast rice on low-density lipoprotein cholesterol (LDL-C) levels in ischemic stroke patients with dyslipidemia.Methods: Quasi-experimental research was conducted in a double-blinded manner. The study was conducted on outpatients at the Neurology Clinic of Dr. Kariadi Hospital Semarang, Central Java, from September to December 2022. Forty subjects with ischemic stroke and dyslipidemia were divided into intervention (20 subjects) and control (20 subjects) groups using consecutive sampling techniques. The intervention was conducted for 30 days. The intervention group received supplementation with a combination of garlic 225 mg, red ginger 125 mg of red ginger, 250 mg of 3x/day and statin for 30 days, while the control group received a placebo and statin. Lipid profile measurements were conducted at the Central Lab of Dr. Kariadi Hospital, Semarang, India. Data were analyzed using Fisher-Exact, Wilcoxon, and paired t-tests at a 95% CI.Results: The average LDL level before intervention was 152,0 ± 58,54, and after the intervention was 89,0 ± 27,07 (mg/dL). Before the intervention, The intermediate cholesterol level was 207,6 ± 37,6 to 164,5 ± 45,58. There was a significant improvement in LDL-C (p= 0,000) and cholesterol (p= 0,001).Conclusion: Supplementation with a combination of garlic, red ginger, and red yeast rice is effective in reducing LDL cholesterol levels

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Effects of garlic extract on lipid profile in patients with coronary artery disease: A systematic review and meta‐analysis of randomised clinical trials

Cited by 10 publications

References 38 publications

Influence of Garlic on the Glycemic Control and Lipid Profile in Animals with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Influence of Garlic on the Glycemic Control and Lipid Profile in Animals with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Potential antihypertensive activity of novel peptides from green basil leaves

Efek suplementasi kombinasi bawang putih, jahe merah, dan beras ragi merah (BJR-22) terhadap kadar kolesterol LDL pasien stroke dengan dislipidemia

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