Effects of Garlic Oil on Pancreatic Cancer Cells

Lan, Xiaoqiang; Sun, Huajun; Liu, J.J.; Lin, Yexin; Zhu, Zhenzhen; Han, Xiaoying; Sun, Xicai; Li, X.R.; Zhang, H.C.; Tang, Z.Y.

doi:10.7314/apjcp.2013.14.10.5905

Cited by 19 publications

(16 citation statements)

References 26 publications

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“…Similar to other gastrointestinal cancers, the increased intake of fresh fruit and vegetables (Allium in particular) is associated with a lower risk of preneoplastic lesions and the onset of pancreatic carcinogenesis [89]. For instance, garlic oil reduces the survival rate of pancreatic cancer cells, inhibits cellular proliferation, and promotes apoptosis in a concentration-dependent manner [90]. Likewise, allicin suppresses viability, DNA damage with epigenetic alterations, caspase-dependent apoptosis, and cell cycle arrest of pancreatic cancer cells along with an accompanying ROS generation [91].…”

Section: Pancreatic Cancermentioning

confidence: 99%

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

Forma

Chilimoniuk

Januszewski

et al. 2021

Gastroenterology Insights

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Herbal medicine is currently widely practiced, since natural resources are reported to alleviate side effects during oncological treatment while modifying cancer cell responses at the same time. Allium vegetables and their constituents have recently been extensively investigated due to the numerous possible beneficial properties, establishing them as an additional treatment modality in different cancers. According to the epidemiological evidence, as well as many in vivo and in vitro studies, the abovementioned substances seem to be effective in the prevention and inhibition of the progression of carcinogenesis. Due to high concentrations of organosulfur compounds, which exhibit anticarcinogenic, antimicrobial, as well as anti-inflammatory properties, Allium constituents are believed to constitute a promising prevention and supportive therapy for oncological patients. Besides, it was demonstrated that a combination of Allium extracts with chemotherapy provided satisfactory clinical outcomes while at the same time being cost-effective. The aim of this review was to present and discuss currently investigated Allium extracts and their effects on several gastrointestinal cancers including gastric, colon, liver, esophageal, and pancreatic cancer.

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Section: Pancreatic Cancermentioning

confidence: 99%

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

Forma

Chilimoniuk

Januszewski

et al. 2021

Gastroenterology Insights

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“…2004, 2006). The effects of garlic or garlic oil in inhibiting cancer growth are also evidenced in several other cancer types including androgen-independent prostate cancer, pancreatic cancer, liver cancer, and breast cancer (Howard et al 2007;Lan et al 2013;Modem et al 2012;). …”

Section: Organosulfur Compounds (Oscs)mentioning

confidence: 99%

Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

2015

Handbook of Experimental Pharmacology

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“…Tissue analysis of xenografted mice revealed that Embelin triggered upregulation of DR4 and DR5 Huang et al, 2014. Garlic oil has been shown to exert its inhibitory effects on proliferation of AsPC-1, PANC-1, and Mia PaCa-2 cells Lan et al, 2013.…”

Section: Molecular Basis Of Trail Resistancementioning

confidence: 99%

TRAIL Mediated Signaling in Pancreatic Cancer

Nogueira

Yaylım²,

Aamir³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Research over the years has progressively shown substantial broadening of the tumor necrosis factor alpharelated apoptosis-inducing ligand (TRAIL)-mediated signaling landscape. Increasingly it is being realized that pancreatic cancer is a multifaceted and genomically complex disease. Suppression of tumor suppressors, overexpression of oncogenes, epigenetic silencing, and loss of apoptosis are some of the extensively studied underlying mechanisms. Rapidly accumulating in vitro and in vivo evidence has started to shed light on the resistance mechanisms in pancreatic cancer cells. More interestingly a recent research has opened new horizons of miRNA regulation by DR5 in pancreatic cancer cells. It has been shown that DR5 interacts with the core microprocessor components Drosha and DGCR8, thus impairing processing of primary let-7. Xenografting DR5 silenced pancreatic cancer cells in SCID-mice indicated that there was notable suppression of tumor growth. There is a paradigm shift in our current understanding of TRAIL mediated signaling in pancreatic cancer cells that is now adding new layers of concepts into the existing scientific evidence. In this review we have attempted to provide an overview of recent advances in TRAIL mediated signaling in pancreatic cancer as evidenced byfindings of in vitro and in vivo analyses. Furthermore, we discuss nanotechnological advances with emphasis on PEG-TRAIL and four-arm PEG cross-linked hyaluronic acid (HA) hydrogels to improve availability of TRAIL at target sites.

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Effects of Garlic Oil on Pancreatic Cancer Cells

Cited by 19 publications

References 26 publications

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

TRAIL Mediated Signaling in Pancreatic Cancer

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