Effects of garlic supplementation on serum inflammatory markers: A systematic review and meta-analysis of randomized controlled trials

Mirzavandi, Farhang; Mollahosseini, Mehdi; Salehi‐Abargouei, Amin; Makiabadi, Elham; Mozaffari‐Khosravi, Hassan

doi:10.1016/j.dsx.2020.06.031

Cited by 12 publications

(11 citation statements)

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“…[ 23 ] Compounds such as allicin, methyl-allyl trisulfide, and S-allyl cysteine exist in garlic have shown anti-inflammatory properties. [ 24 ] In addition, onion has been reported to boost the immune system,[ 25 ] but future studies are required to assess the effects of them on COVID-19 infection.…”

Section: Discussionmentioning

confidence: 99%

Did Iranians change their eating behavior following COVID-19 outbreak?

Akbarzadeh

Barati‐Boldaji

Mohsenpour

et al. 2021

Journal of Research in Medical Sciences

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Background: Significant lifestyle changes have been reported after COVID-19 outbreak. The present study aimed at investigating changes in dietary habits in response to the COVID-19 outbreak in an Iranian population sample. Materials and Methods: In this cross-sectional study, the dietary habits of Iranian adults were assessed before and during the COVID-19 outbreak. Consumption of different food groups such as meats, dairy, fruits, vegetables, seeds, and nuts was assessed using a digital questionnaire which was shared on social media platforms. For the statistical analysis, the Wilcoxon signed-rank test was used. Results: In this online survey, 1553 questionnaires were completed. The results showed that the reported consumption of protein-rich foods increased ( P < 0.05), but fish and dairy consumption showed a significant reduction ( P = 0.006 and <0.001, respectively). There was a significant reduction in reported fast-food consumption ( P < 0.001). Fruits and vegetables ( P < 0.001), natural fruit juices ( P < 0.001), and water ( P < 0.001) were consumed more frequently. Individuals also consumed more vitamin and mineral supplements ( P < 0.001) including those containing Vitamin D. Conclusion: During the COVID-19 pandemic, participants reported a significant change in their dietary habits and intake of supplements. Higher intakes of meats, protein-rich foods, fruits, vegetables, and nutritional supplements and lower intakes of fish, dairy, and fast foods were reported.

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Section: Discussionmentioning

confidence: 99%

Did Iranians change their eating behavior following COVID-19 outbreak?

Akbarzadeh

Barati‐Boldaji

Mohsenpour

et al. 2021

Journal of Research in Medical Sciences

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“…The main constituents of garlic are organosulfur compounds and flavonoids which have antioxidant and anti-inflammatory properties including allicin, methyl-allyl trisulfide and SAC, and diallyl disulfide, and sulfoxides [ 32 33 ]. Previous meta-analyses reported that garlic supplementation can reduce inflammation [ 34 35 ]. Garlic consumption reduces C-reactive protein (CRP) levels by controlling interleukin-10, which suppressed the production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Garlic (Allium sativum L) Supplementation on Circulating Adiponectin: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2021

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Our aim was to conduct a systematic review and meta-analysis on randomized controlled trials (RCTs) evaluating the effect of garlic on serum adiponectin levels. We searched Scopus, Web of Science, PubMed, and Cochrane Library to databases up to January 2021. RCTs investigating the effects of garlic on serum adiponectin levels in adult participants were included. The change in serum adiponectin levels was estimated using weighted mean differences (WMD) and standard deviations (SD). The random effects model was used to provide a summary of mean estimates and their SDs. Out of 386 records, 6 trials with 8 arms treatment which enrolled 266 subjects were included. Garlic supplementation resulted in a non-significant increase in adiponectin concentrations when compared to placebo, according to the pooled data (WMD, 0.27 Hedges' g; 95% confidence interval [CI], −0.07, 0.62; p = 0.124). Greater effects on adiponectin were observed in trials with supplementation dose less than 1.5 gram per day (WMD, 0.71 Hedges' g; 95% CI, −0.01, 1.43; p = 0.600) and in trials with female subset (WMD, 0.62 Hedges' g; 95% CI, −0.96, 2.21; p = 0.441). Garlic boosts adiponectin levels in general. However, due to different target population, various units for reporting adiponectin level and few eligible studies in final analysis, more research is needed to get a firm conclusion about the influence of garlic on adiponectin levels.

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“…Hussein and Sharara (2007) demonstrated that the daily consumption of 900 mg of garlic (capsules) for 8 weeks significantly decreased the concentration of TNF-α in patients with knee OA. Likewise, a meta-analysis of randomized controlled trials and a randomized, double-blind study in obese adults with low-grade inflammation have also reported a significant reduction in serum TNF-α concentrations due to supplementation with AGE (Mirzavandi et al, 2020;Xu et al, 2018). However, certain trial studies showed that garlic supplementation does not change plasma levels of TNF-α (Aalami-Harandi et al, 2015;Faranak et al, 2010;Mahdavi-Roshan et al, 2016).…”

Section: Garlic Preparations In Clinical Studiesmentioning

confidence: 99%

Antinociceptive effect of garlic, garlic preparations and derivative compounds

Hernández-Cruz

Silva-Islas

Maldonado

et al. 2022

European Journal of Pain

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Background and objective:The antinociceptive effects of garlic have shown promise in treating different chronic diseases in humans, such as knee osteoarthritis, rheumatoid arthritis and peripheral arterial occlusive disease stage II.The most common garlic products are garlic powder (dried garlic), steam distilled garlic oils, garlic oil macerate and aged garlic extract. These commercial products contain organosulphur compounds (OSCs) that have been extensively evaluated in preclinical models and some clinical assays to treat different diseases against pain. In this review, we describe the importance of some bioactive compounds found in garlic and their role in treating pain. Materials & Methods:A systematic search of the literature in Dimensions, PubMed, Scopus, and Web of Science was performed. Terms and preselected keywords relating to garlic, its derivatives and organusulphure compounds in acute, chronic and neuropathic pain, were used to perform a systematic literature search. Two independent reviewers screened the papers for inclusion and assessed the methodological quality. Results & Discussion:The antinociceptive activity of garlic and its OSC is related to its antioxidant and anti-inflammatory properties, which may be explained by the ability to block the synthesis of PGs, pro-inflammatory cytokines and interferon-γ, by the reduction COX-2 activity and increasing the levels of anti-inflammatory cytokines. Besides, garlic extract is an activator of TRPA1 and TRPV1, where the principal responsible for this activation are OSC. Conclusion:The relationship between these pathways allows a better understanding how garlic and its derivates could be carrying out its pharmacological action over the management of acute and chronic pain and provide a base by further investigations.Significance: Antinociceptive effect of garlic and its OSCs has been extensively evaluated in preclinical models and clinical assays to treat different diseases, contributing to the modulation of inflammation as an essential factor in reducing pain. The current review emphasizes the potential therapeutic effect of garlic and its derivatives in treatment of pain and related mechanisms of action. Moreover, it provides information about the potential clinical use in patients with painful conditions.

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Effects of garlic supplementation on serum inflammatory markers: A systematic review and meta-analysis of randomized controlled trials

Cited by 12 publications

References 50 publications

Did Iranians change their eating behavior following COVID-19 outbreak?

Did Iranians change their eating behavior following COVID-19 outbreak?

The Effect of Garlic (Allium sativum L) Supplementation on Circulating Adiponectin: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Antinociceptive effect of garlic, garlic preparations and derivative compounds

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