Effects of genetic factors to inhaled corticosteroid response in children with asthma: a literature review

Duong-Thi-Ly, Huong; Nguyen-Thi-Thu, Ha; Nguyen-Hoang, Long; Nguyen-Thi-Bich, Hanh; Craig, Timothy J.; Duong‐Quy, Sy

doi:10.1177/0300060516683877

Cited by 21 publications

(22 citation statements)

References 57 publications

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“…Even though the reason behind childhood asthma is not known, concurrent research showed a combination of environmental contacts and inherited biological, genetic talents [ 6 ]. Pulmonary contacts of its environmental causes are inhaled allergens, viral respiratory infections and chemical contaminants, viral respiratory infections and chemical and biological air pollutants like tobacco smoke in the environment [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Children with Asthma versus Healthy Children

Kouzegaran¹,

Samimi²,

Ahanchian³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Asthma is the most prevalent chronic disease in the pediatric age group. The disease affects different aspects of the children’s lives, such as physical, emotional, social and educational aspects. Thus, more focus has been on the quality of life in these patients rather than the duration of their illness in recent years.AIM:This study examined the different aspects of quality of life in asthmatic children for the first time in this geographic area.METHODS:The study was cross-sectional conducted in 2015-2016. The asthmatic group was 100 patients aged 8 to 12 admitted to the Asthma and Allergy Clinic of Ghaem Hospital (as) in Mashhad with the control group composed of 100 healthy children of the same age and gender. The standard questionnaire pedsQLTM was used for comparing the quality of life of children in the two groups. Statistical analysis was SPSS23 with P-value less than 0.05, which was statistically significant.RESULTS:In each group, 58 patients were boys, and 42 were girls. In a comparison of the quality of life of children, the asthma group with a mean total score of Peds QL 20.99 ± 12.54 compared to the healthy children with a mean total score of Peds QL of 8.8 ± 5.41 had a lower quality of life (P < 0.001). Moreover, regarding various aspects of quality of life asthma group had a lower quality of life in physical performance, emotional performance and performance in school (P < 0.001). Nonetheless, there was no significant difference between the two groups considering social function (P = 0.267). Examining the relationship between Peds QL score of patients with asthma with various variables was indicative of the fact that Peds QL scores were significantly correlated with the gender of the patients, showing better quality of life in the girls (P = 0.001).CONCLUSION:The results indicated that children with asthma have a significantly lower quality of life compared with healthy children of the same age. Also, in examining the different aspects of quality of life, these children had a lower quality of life in physical performance, emotional performance, and performance at school, and were at the level as that of healthy children only in social performance.

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Section: Introductionmentioning

confidence: 99%

Quality of Life in Children with Asthma versus Healthy Children

Kouzegaran¹,

Samimi²,

Ahanchian³

et al. 2018

Open Access Maced J Med Sci

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“…Asthma is a multifactorial disease, which means that both genetic and environmental factors contribute to its development. In fact, genetic factors affect the responses to anti‐asthma drugs in about 60%‐80% of individuals . Currently, complete understanding of the asthma genetics and related pathologic processes has not yet been achieved; therefore, the existing system of diagnosis and treatment of asthma needs further development.…”

Section: Discussionmentioning

confidence: 99%

An investigation of the association between ADRB2 gene polymorphisms and asthma in Kazakh population

Akparova

Aripova

Abishev³

et al. 2020

Clinical Respiratory J

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Introduction: Beta-2-adrenergic receptor (ADRB2) is present in the cells of the respiratory tract, including bronchial smooth muscle cells and bronchial epithelium, and is a target for endogenous catecholamines and drugs used to treat the obstructive lung diseases. Objectives: This study aimed to investigate the possible association of the Arg16Gly and Gln27Glu polymorphisms of the ADRB2 gene with asthma and its endophenotypes in the Kazakh population. Methods: A total of 70 asthmatic patients and 80 healthy controls were genotyped for Arg16Gly and Gln27Glu polymorphisms of the ADRB2 gene by using quantitative real-time polymerase chain reaction. Statistical analysis was performed with the Graph Pad InStat 7 Software. Results: No associations between the asthma patients and healthy individuals were found when the allele and genotype distribution of Arg16Gly and Gln27Glu single nucleotide polymorphisms were compared. Analysis of the haplotype frequencies showed statistically significant differences between patients with asthma and controls for Arg16Gly/Gln27Gln and Arg16Gly/Gln27Glu haplotypes (odds ratio [OR] = 2.12, 95% confidence interval [CI] = 0.87-5.16 and OR = 2.25, 95% CI = 0.89-5.67 respectively). The Arg16 allele and Arg16Arg genotype frequencies were higher in patients with uncontrolled asthma than in controls (χ 2 = 5.17, df = 1, P = 0.02 and χ 2 = 5.36, df = 1, P = 0.02 respectively). Conclusion:The results of this study support the possible involvement of Arg16Gly polymorphism in the development of uncontrolled asthma, and indicate that Arg16Gly/Gln27Gln and Arg16Gly/Gln27Glu haplotypes are more common in asthma patients in the Kazakh population. K E Y W O R D Sasthma, beta-2-adrenergic receptor, Kazakhstan, single nucleotide polymorphisms

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“…The low‐affinity IgE receptor, CD23, by nature inhibits IgE production . The FCER2 gene affects the inflammatory mechanisms and results in the variability in the response to ICS in asthma . The T2206C variant is located in splicing region of intron 9 of FCER2 and might lead to alternative splicing and changes of the gene transcript length.…”

Section: Discussionmentioning

confidence: 99%

“…gene affects the inflammatory mechanisms and results in the variability in the response to ICS in asthma. 35 The T2206C variant is located in splicing region of intron 9 of FCER2 and might lead to alternative splicing and changes of the gene transcript length. Tantisira et al showed that the T2206C variant was associated with lower FCER2 gene expression.…”

Section: Discussionmentioning

confidence: 99%

FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study

Karimi¹,

Vijverberg

Farzan

et al. 2019

Clin Experimental Allergy

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BackgroundThe FCER2 gene, via encoding of the CD23 receptor, plays an important role in the regulation of IgE responses. A genetic variant of the FCER2 gene (T2206C) was previously shown to be associated with IgE levels in asthmatic children. IgE sensitization has also been linked to increased levels of fractional exhaled nitric oxide (FENO).ObjectiveTo investigate whether the FCER2 T2206C variant influences FENO levels in asthmatic children with a reported use of inhaled corticosteroids (ICS).MethodsThis cross‐sectional study involved 593 asthmatic children with a reported use of ICS, availability of FENO measurements and genotyping data on the FCER2 T2206C variant (rs28364072). An additive genetic model was assumed, and the association between the FCER2 T2206C variant and the log‐transformed (ln) FENO levels was evaluated using linear regression analysis, adjusted for age, sex, adapted British Thoracic Society (BTS) treatment steps and atopy.ResultsThe mean age of the population was 9.1 ± 2.2 years, and the median of FENO levels was 13.0 ppb with an interquartile range (IQR) of (8.0‐27.5 ppb). The minor allele (G) frequency of rs28364072 was 29.6%, and each extra copy of the G allele was significantly associated with a lower level of the geometric mean of FENO (log scale, β = −0.12, 95% CI: −0.23, −0.02).Conclusion and Clinical RelevanceOur results showed that the FCER2 T2206C variant was significantly associated with lower FENO levels in carriers of the G allele. Nevertheless, this SNP contributed little to the variability in FENO levels in this patient population. Our findings contribute to the present knowledge on FENO in asthmatic children; however, future replication studies are required to establish the role of this gene in relation to FENO.

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Effects of genetic factors to inhaled corticosteroid response in children with asthma: a literature review

Cited by 21 publications

References 57 publications

Quality of Life in Children with Asthma versus Healthy Children

Quality of Life in Children with Asthma versus Healthy Children

An investigation of the association between ADRB2 gene polymorphisms and asthma in Kazakh population

FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study

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