Effects of Genetic Polymorphisms of N-Acetyltransferase on Trichloroethylene-Induced Hypersensitivity Dermatitis among Exposed Workers

Dai, Yufei; Leng, Song; Li, Laiyu; Niu, Yong; Huang, Hanlin; Liu, Qingjun; Duan, Huawei; Cheng, Juan; Liu, Qing; Zheng, Yuxin

doi:10.2486/indhealth.47.479

Cited by 20 publications

(23 citation statements)

References 29 publications

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“…N-acetyltransferase is an important metabolic enzyme in the conjugation pathway of TCE metabolism. 11 NAT includes two isoenzymes, NAT1 and NAT2, which are encoded by two separate genes and exhibit multiple genetic polymorphisms. A previous investigation indicated that slow or intermediate NAT2 acetylators are at increased risk of HS-induced skin disorders, compared with tolerant TCE workers.…”

Section: Polymorphisms In Tumor Necrosis Factor (Tnf)-a and N-acetyltmentioning

confidence: 99%

“…3,7 When we analyzed TCE-induced skin disorders in the published work, many patients have the latter manifestation, characterized by an onset of the reaction, clinical features and laboratory data that are quite similar to those of drug-induced hypersensitivity syndrome (DIHS), 8,9 also referred to as drug rash with eosinophilia and systemic symptoms (DRESS). 10 In fact, Dai et al 11 recently observed that only three of 111 TCErelated generalized skin reaction patients had SJS ⁄ TEN, and the remainder had HS; the authors categorized the other patients as 75 with exfoliative dermatitis and 33 with erythema multiforme, but these are included in HS, as described below. Thus, this review of TCE-induced skin disorders discusses primarily the hypersensitivity syndrome type, and reviews similarities between TCE-induced HS and DIHS.…”

Section: Introductionmentioning

confidence: 99%

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Hypersensitivity syndrome due to trichloroethylene exposure: A severe generalized skin reaction resembling drug‐induced hypersensitivity syndrome

Watanabe

2011

The Journal of Dermatology

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The number of patients suffering from trichloroethylene (TCE)-related severe skin disorders with liver dysfunction has been increasing in developing countries in Asia, especially since the mid-1990s. In Japan, five cases of this disease have been reported, but none since the 1990s. However, two additional cases were recently observed in Tokyo. The published work and our investigation indicated that oxidative metabolites of TCE, which might include trichloroacetylated-protein adducts, could induce a generalized skin eruption. Furthermore, human leukocyte antigen (HLA)-B*1301 and HLA-B*44 were identified as markers of individual susceptibility to TCE-induced hypersensitivity syndrome (HS). Moreover, polymorphism of aldehyde dehydrogenase (ALDH), the major enzyme in TCE metabolism, appeared to be associated with TCE-induced HS. Interestingly, this disorder is quite similar to druginduced hypersensitivity syndrome (DIHS), also referred to as drug rash with eosinophilia and systemic symptoms (DRESS), from the perspective of the onset of the reaction after exposure to TCE ⁄ drugs, clinical manifestations, blood examination and period of virus reactivation. This article reviews the similarity between TCE-related HS and DIHS ⁄ DRESS.

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Section: Polymorphisms In Tumor Necrosis Factor (Tnf)-a and N-acetyltmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypersensitivity syndrome due to trichloroethylene exposure: A severe generalized skin reaction resembling drug‐induced hypersensitivity syndrome

Watanabe

2011

The Journal of Dermatology

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“…At present, biomarker researches about OMLDT mainly focused on three aspects: gene polymorphism [3][4][5][6][7], serum proteomics [8][9][10][11][12] and TCE metabolites [13]. Haishan Li, et al [3] identified genetic susceptible biomarkers associated with OMLDT in genes located in the human leukocyte antigen (HLA) region.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Change of Serum Proteomics of Occupational Medicamentosalike Dermatitis Induced by Trichloroethylene

Liu¹,

Hong²,

Zhang³

et al. 2015

J Clin Toxicol

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Objective: Extensive researches about biomarkers of Occupational medicamentosa-like dermatitis induced by Trichloroethylene (OMLDT) have been carried out in recent years. But dynamic change of protein biomarkers in serum has rarely been reported. The aim of our study was to explore the dynamic changing law of serum proteins/ polypeptides in different periods of OMLDT, identify potential biomarkers and provide the scientific fundamentals for monitoring the progression of the disease and screening high-risk population. Study design:We developed an approach in the combination of magnetic beads based weak cation exchange chromatography (MB-WCX), matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) and ClinProTools software. Based on the alternations in the polypeptides fingerprint of serum (PFS), we built diagnostic models of OMLDT, and screened the special proteins/ polypeptides biomarkers and further studied the dynamic changing law of different periods in typical OMLDT patients. Results:We attained 72 peaks which were statistical content in OMLDT/Normal model, of which 52 peaks were differential peaks. We also obtained 69 significant peaks in OMLDT/TCE Contact model, but the differential peaks were 35. There were 21 specific peaks which were alike among the differential peaks in these two models and the change of their expression level was consistent. Among the 21 specific peaks, we found 4 peaks, which were m/z 410942675065 and 9287Da, changed nearly the same in 3 periods of 4 recurrent patients, and 2 peaks (4109 and 9173 Da) changed consistent in 3 periods of 3 stable patients. Interestingly, m/z 4109 Da appeared in both groups and the expression level was increased with the course of disease. So it may be the special serum biomarker of OMLDT. Conclusion:Overall, the results indicate specific PFS could serve as a useful tool to reflect the dynamic change of proteins/ polypeptides in different periods of OMLDT. And it may provide a new clue for clinical application.

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“…This special issue of Industrial Health, "Individual Susceptibility to Occupational Hazard", deals with the individual variability in the effects of various occupational factors including nine articles which refer to chemical [15][16][17][18] , psychosocial [19][20][21] , biological 22,23) and physical factors 24) . The articles regarding chemical factors include a systematic review by Julvez and Grandjean on neurodevelopmental toxicity 15) .…”

mentioning

confidence: 99%

“…Miura 17) presents a review on the individual susceptibility to cadmium toxicity, suggesting that if workers are exposed to industrial materials that have a inhibitory mechanism similar to that of DL-propargylglycine , an inhibitor of the cystathionine pathway (cystathionase inhibitor), free cadmium ions accumulate in the body due to the absence of metallothionein, resulting in serious renal dysfunction. In their original article, Zheng et al 18) report the genetic polymorphisms of N-acetyltransferase (NATs) are related to trichloroethylene -induced hypersensitivity dermatitis. They suggest that slow metabolic phenotype of NAT2 maybe one of risk factor for the dermatitis and combined slow acetylator phenotypes of NAT1 and NAT2 further increase such risk.…”

mentioning

confidence: 99%

Individual Susceptibility to Occupational Hazard

Yokoyama¹

2009

Ind Health

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Effects of Genetic Polymorphisms of N-Acetyltransferase on Trichloroethylene-Induced Hypersensitivity Dermatitis among Exposed Workers

Cited by 20 publications

References 29 publications

Hypersensitivity syndrome due to trichloroethylene exposure: A severe generalized skin reaction resembling drug‐induced hypersensitivity syndrome

Hypersensitivity syndrome due to trichloroethylene exposure: A severe generalized skin reaction resembling drug‐induced hypersensitivity syndrome

Dynamic Change of Serum Proteomics of Occupational Medicamentosalike Dermatitis Induced by Trichloroethylene

Individual Susceptibility to Occupational Hazard

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