Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population

Abstract

This article is available online at http://www.jlr.org on lipid parameters and dyslipidemia in a Chinese population. J. Lipid Res. 2011. 52: 354-360. Supplementary key words genetic polymorphisms • lipid levels • strokeDyslipidemia is a common health problem in developing countries, including China ( 1 ). A vast line of evidence has demonstrated that plasma lipids and lipoprotein concentrations are important risk factors for atherosclerosis and related vascular diseases, which are the leading causes of death in China and the rest of the world ( 2, 3 ). Although plasma lipid concentrations are strongly infl uenced by smoking, diet, level of physical activity, and other lifestyles choices, twin and family studies suggest that about 50% of the variation in HDL cholesterol (HDL-C), LDL-C, and total cholesterol (TC) levels is genetically determined ( 4 ).Since 2008, genome-wide association (GWA) studies of plasma lipid levels have further identifi ed several common variants associated with plasma lipid levels, exerting a modest fraction of variance (2% or less) ( 5-15 ). Some newly identifi ed genes are potential new drug targets, so these recent genetic advances have broadened our understanding of basic metabolic pathways and can improve patient classifi cation, disease diagnosis, and treatment strategies ( 14 ). However, because of the known differences in genome-wide linkage disequilibrium patterns among Abstract A number of recent genome-wide association (GWA) studies have identifi ed several novel genetic determinants of plasma lipid and lipoprotein concentrations in European populations. However, it is still unclear whether these loci identifi ed in Caucasian GWA studies also exert the same effect on lipid and lipoprotein concentrations in a Chinese population. We genotyped 10 single-nucleotide polymorphisms (SNPs) in nine loci in a Chinese Han population sample (n = 4,192) and assessed the associations of these SNPs with metabolic traits, using linear regression adjusted for age, gender, diabetes status, and body mass index. Three variants (rs12654264, P ~ 1.7 × 10 ؊ 6 ; rs3764261, P ~ 7.1 × 10 ؊ 7 ; and rs4420638, P ~ 1.1 × 10 ؊ 3 ) showed strong evidence for association with total cholesterol; four variants (rs780094, P ~ 1.8 × 10 ؊ 11 ; rs17145738, P ~ 5.0 × 10 ؊ 7 ; rs326, P ~ 2.3 × 10 ; and rs4420638, P ~ 3.6 × 10 ؊ 4 ) showed strong evidence for association with LDL-C, and four variants (rs326, P ~ 2.8 × 10 ؊ 3 ; rs1800588, P ~ 6.1 × 10 ؊ 4 ; rs3764261, P ~ 2.0 × 10 ؊ 3 ; and rs4420638, P ~ 9.4 × 10 ؊ 5 ) showed strong evidence for association with total cholesterol-HDL-C-related ratio. These SNPs generated strong combined effects on lipid traits and dyslipidemia. Our fi ndings indicate that the variants that associated with metabolic traits in Europeans may also play a role in a Chinese Han

Gene polymorphisms and gene scores linked to low serum carotenoid status and their associations with metabolic disturbance and depressive symptoms in African-American adults

“…(22; 61) A study conducted among a large cohort of Chinese adults (n=4,194) showed that the “T” allele was linked to higher HDL-C level than the “C” allele (p<0.0001). (62) The same pattern was found in a large cohort study of Caucasian adults (n=4,662) with the “C” allele being associated with dyslipidemia-HDL-C (p<0.0001). (63) Our study failed to detect an association between LIPC SNPlcar and various outcomes of interest.…”

Functional Variants of Lipid Level Modifier MLXIPL, GCKR, GALNT2, CILP2, ANGPTL3 and TRIB1 Genes in Healthy Roma and Hungarian Populations

“…In a case-control study, which was performed on Han Chinese population analyzing 4192 individuals for type 2 diabetes, the association between elevated triglyceride levels and genotypes for MLXIPL rs17145738 variant and for GCKR rs780094 was confirmed, but not for GALNT2 rs4846914 polymorphism [46].…”

Association of Genetic Loci with Blood Lipids in the Chinese Population

“…These associations were primarily found in European ancestry. Following studies successfully replicated most of these loci in East Asian population [12], [13], [14], [15], [16], [17]. However, some of the loci showed no significant association with lipid and lipoprotein levels in Asian population, including the MAFB , NCAN/CLIP2/PBX4 and MVK/MMAB loci [12], [14], [17].…”