“…In contrast, microcone patch skin stimulation directly stimulates the skin using a patch densely packed with extremely fine projections [11,12,19] and is suggested to change autonomic response or brain activity. Unlike taVNS, microcone patches do not require specialized techniques or equipment, and the patch itself is not considered a medical procedure, making it suitable for self-medication [12]. In a study on chronic pain, the microcone patch was reported to suppress the "slow" reflex involved in the emotional aspect of pain in the somatosensory nerves by up to 60% [19,20].…”