Effects of GH assay standardization on evaluation of treatment outcomes for acromegaly in Japan

Izumi, Fujio; Kurimoto, Makiko; Tanaka, Satoshi; Yamakado, Yu; Muraoka, Toko; Takano, Kazue; Hizuka, Naomi

doi:10.1507/endocrj.k11e-099

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…The diagnosis of functional pituitary adenomas (FPAs) was performed in accordance with previous reports (15)(16)(17)(18)(19). In detail, a growth hormone (GH)-producing adenoma was diagnosed based on a combination of increased GH levels, unsuppressed GH levels after a 75-g oral glucose tolerance test, increased insulin-like growth factor (IGF)-1 levels, and pathology studies in patients who underwent surgical treatment.…”

Section: Functional Pituitary Adenomasmentioning

confidence: 92%

Clinical investigation of pituitary incidentalomas: A two-center study

Ishii

Abe

Kameda

et al. 2019

IRDR

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Pituitary incidentalomas (PIs) are tumors of the pituitary gland discovered unexpectedly upon imaging that are not due to symptoms related specifically to the lesion (e.g., visual loss) or a clinical manifestation of hormonal disorders (1). Vernooij and colleagues reported analysis of patient with magnetic resonance imagings of the brain showed PIs were present in 1.6% persons (2). The previous autopsy investigations also showed the prevalence of PIs were 2.7-24.0 % (3-5). Whereas, adrenal incidentalomas, the same endocrine incidental tumors as PIs, have been investigated in several studies (6-9), even though their prevalence investigated by autopsy were reported to be lower than that of PIs (1.1-5.0 %) (10-12). However, few studies have focused on PIs (2,13,14). Summary Recent advances in imaging technology resulted in an increase in pituitary incidentalomas (PIs) detection. PIs were reported to be present in 1.6% persons with magnetic resonance imaging of the brain. Whereas, there were few studies about PIs with detailed investigation. We aimed to investigate the clinical and endocrinological characteristics of PIs. We evaluated 65 patients diagnosed with PIs who underwent detailed clinical and endocrinological evaluations. Of the 65 patients, 33 (50.8%) had non-functional pituitary adenomas (NFPAs), 11 (16.9%) had Rathke's cleft cysts (RCCs), 7 (10.8%) had functional pituitary adenomas (FPAs), 6 (9.2%) had benign extra-pituitary tumors (BEPTs), and 8 (12.3%) had malignant tumors (MTs). Compared with patients with NFPAs, those with MTs were significantly younger and had a significantly lower body mass index, lower prevalence of hypertension, and lower prevalence of dyslipidemia. Patients with MTs had significantly higher prevalence of central diabetes insipidus than those with NFPAs. In addition, patients with NFPAs had significantly higher prevalence of pituitary apoplexy than those with FPAs, BEPTs, and MTs. In conclusion, our study demonstrated clinical and endocrinological characteristics of PIs. Highly detailed clinical and endocrinological investigations should be performed for PIs. In addition, MTs should be considered in the differential diagnosis for young and lean patients with central diabetes insipidus.

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