Effects of ginger and its pungent constituents on transient receptor potential channels

Kim, Youngsoo; Hong, Chansik; Lee, Sang Weon; Nam, Joo Hyun; Kim, Byung Joo

doi:10.3892/ijmm.2016.2791

Cited by 20 publications

(11 citation statements)

References 61 publications

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“…Ginger is known for having more than 60 active compounds, broadly divided into volatile and nonvolatile compounds [ 6 ]. Volatile components include hydrocarbons, meanwhile rhizome from ginger contains nonvolatile pungent phenolic compounds like 6-gingerol, 6-shagol, 6-paradol, and zingerone [ 7 ] ( Figure 1 , Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer

Zadorozhna

Mangieri

2021

IJMS

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Ginger (Zingiber officinale Roscoe, family: Zingiberaceae), originating in South-East Asia, is one of the most used spices and condiments for foods and beverages. It is also used in traditional medicine for many human disorders including fever, gastrointestinal complications, arthritis, rheumatism, hypertension, and various infectious diseases due to its anti-inflammatory, antioxidant, antimicrobial, and antiemetic properties. Intriguingly, many recent studies evidenced the potent chemopreventive characteristics of ginger extracts against different types of cancer. The aim of this work is to review the literature related to the use of ginger extracts as a chemotherapeutic agent and to structure the cellular and molecular mechanisms through which ginger acts in different cancer types. Data summarized from experiments (in vitro or in vivo) and clinical studies, evidenced in this review, show that ginger derivatives perpetrate its anti-tumor action through important mediators, involved in crucial cell processes, such as cell cycle arrest, induction of cancer cell death, misbalance of redox homeostasis, inhibition of cell proliferation, angiogenesis, migration, and dissemination of cancer cells.

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Section: Introductionmentioning

confidence: 99%

Mechanisms of Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer

Zadorozhna

Mangieri

2021

IJMS

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“…The cis-C6 double bond in the polyenic chain of a-SOH is critical for TRPA1 activation and no structural specificity is required for TRPV1 activation (521). Alkylamides and 6-shogaol act on TRPA1 by covalent bonding, whereas none of these compounds activate TRPV1 through such interactions (391,681).…”

mentioning

confidence: 99%

Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease

Talavera

Startek

Alvarez‐Collazo

et al. 2020

Physiological Reviews

288

274

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The transient receptor potential ankyrin (TRPA) channels are Ca2+-permeable nonselective cation channels remarkably conserved through the animal kingdom. Mammals have only one member, TRPA1, which is widely expressed in sensory neurons and in non-neuronal cells (such as epithelial cells and hair cells). TRPA1 owes its name to the presence of 14 ankyrin repeats located in the NH2 terminus of the channel, an unusual structural feature that may be relevant to its interactions with intracellular components. TRPA1 is primarily involved in the detection of an extremely wide variety of exogenous stimuli that may produce cellular damage. This includes a plethora of electrophilic compounds that interact with nucleophilic amino acid residues in the channel and many other chemically unrelated compounds whose only common feature seems to be their ability to partition in the plasma membrane. TRPA1 has been reported to be activated by cold, heat, and mechanical stimuli, and its function is modulated by multiple factors, including Ca2+, trace metals, pH, and reactive oxygen, nitrogen, and carbonyl species. TRPA1 is involved in acute and chronic pain as well as inflammation, plays key roles in the pathophysiology of nearly all organ systems, and is an attractive target for the treatment of related diseases. Here we review the current knowledge about the mammalian TRPA1 channel, linking its unique structure, widely tuned sensory properties, and complex regulation to its roles in multiple pathophysiological conditions.

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“…The chemical activators group is divided in turn into two subgroups depending on the origin of the activator/modulator: exogenous and endogenous. Exogenous stimuli are capsaicin [ 38 ] and its antagonist capsazepine [ 39 ], resiniferatoxin (RTX) [ 37 , 40 ], bradykinin [ 41 ], yohimbine [ 42 ], ethanol [ 43 ], evodiamine [ 44 ], 17-β-estradiol [ 45 ], quinazoline [ 46 ], progesterone [ 47 ], numerous opioids [ 48 ], nicotine [ 49 ], hyaluronan [ 50 ], insulin [ 51 ], tinyatoxin [ 52 ], olvanil [ 53 ], acetylsalicylic acid [ 54 ], eugenol [ 55 ], sesquiterpenes [ 56 , 57 , 58 ], cannabidiol [ 59 ], prenylphenols [ 60 ], zingerone [ 61 ], shogaol [ 61 ], PPAHV [ 62 ], gingerol [ 63 ], numerous pharmacological antagonists [ 64 , 65 , 66 , 67 ], and peptide toxins from different species [ 4 , 68 ]. Endogenous activators comprise numerous compounds [ 1 ], such as the wide family derived from polyunsaturated fatty acids (PUFAs).…”

Section: Figurementioning

confidence: 99%

Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review

Ramal-Sanchez

Bernabò

Valbonetti

et al. 2021

IJMS

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Based on the abundance of scientific publications, the polymodal sensor TRPV1 is known as one of the most studied proteins within the TRP channel family. This receptor has been found in numerous cell types from different species as well as in spermatozoa. The present review is focused on analyzing the role played by this important channel in the post-ejaculatory life of spermatozoa, where it has been described to be involved in events such as capacitation, acrosome reaction, calcium trafficking, sperm migration, and fertilization. By performing an exhaustive bibliographic search, this review gathers, for the first time, all the modulators of the TRPV1 function that, to our knowledge, were described to date in different species and cell types. Moreover, all those modulators with a relationship with the reproductive process, either found in the female tract, seminal plasma, or spermatozoa, are presented here. Since the sperm migration through the female reproductive tract is one of the most intriguing and less understood events of the fertilization process, in the present work, chemotaxis, thermotaxis, and rheotaxis guiding mechanisms and their relationship with TRPV1 receptor are deeply analyzed, hypothesizing its (in)direct participation during the sperm migration. Last, TRPV1 is presented as a pharmacological target, with a special focus on humans and some pathologies in mammals strictly related to the male reproductive system.

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Effects of ginger and its pungent constituents on transient receptor potential channels

Cited by 20 publications

References 61 publications

Mechanisms of Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer

Mechanisms of Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer

Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease

Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review

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