Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilers

AbdelMaksoud, Eman; Daha, Ahmed Abd El Fattah; Taha, Nabil M.; Lebda, Mohamed A.; Sadek, Kadry M.; Alshahrani, Mohammad Y.; Ahmed, Ahmed Ezzat; Shukry, Mustafa; Fadl, Sabreen E.; Sobhy, Mohamed

doi:10.1016/j.psj.2023.102903

Cited by 6 publications

(3 citation statements)

References 56 publications

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“…Further analysis of the blood of the test broilers showed that the DHF increased the number of lymphocytes, which was observed at both 21 and 35 days. This suggested that the herbal medicine promoted the development of immune organs and the differentiation of lymphocytes, which had a positive effect on the improvement of broiler immunity [ 50 , 51 , 52 ]. Meanwhile, the present study observed that, at 35 days, lymphocytes were still higher than those in the CON group, although the immune organ traits were the same as those of the CON group.…”

Section: Discussionmentioning

confidence: 99%

Effects of Designed Herbal Formula on Growth Performance, Blood Indices, Organ Traits, and Cecum Microbiology in Broilers

Sun,

Zhang,

Shi

et al. 2024

Veterinary Sciences

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The objective of this study was to investigate the effect of the designed herbal formula (DHF) on growth performance, blood indices, organ traits, and cecum microbiology in broilers. A total of 96 male broilers of 1 d were selected and randomly assigned to two groups with six replicates of eight broilers each. The control (CON) and the basal diet containing 1.0% DHF (Astragali radix, Atractylodes macrocephala Koidz., Isatis tinctoria Linnaeus, and Citri reticulatae pericarpium, 2:1:1:2) were fed separately. The experiment was conducted for 35 days. The results showed that the DHF diet increased body weight and decreased the feed conversion ratio (FCR) (p < 0.05). At 21 days, the spleen, thymus, lymphocytes, and thrombocytes were increased (p < 0.05), and pancreas, duodenum, heterophils, and mean corpuscular hemoglobin (MCH) were decreased (p < 0.05). At 35 days, the heart, pancreas, white blood cell, heterophils, hemoglobin, MCH and mean corpuscular hemoglobin concentration (MCHC) were decreased, while lymphocytes and middle cells were increased (p < 0.05). The results of microbial diversity analysis showed that the DHF diet decreased the microbial diversity of the cecum. Firmicutes and Bacteroidetes were the dominant phyla, where the DHF diet increased the relative abundances of Bacteroides uniformis, Bacteroides vulgatus, and Faecalibacterium prausnitzii, and then decreased the relative abundance of Shigella sonnei. In conclusion, DHF played a positive role in improving the growth performance, immune performance, and relative abundance of Bacteroides uniformis, Bacteroides vulgatus, and Faecalibacterium prausnitzii in cecum microbiology in broilers, and has the potential to be used as a novel feed additive.

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Section: Discussionmentioning

confidence: 99%

Effects of Designed Herbal Formula on Growth Performance, Blood Indices, Organ Traits, and Cecum Microbiology in Broilers

Sun,

Zhang,

Shi

et al. 2024

Veterinary Sciences

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“…In other studies, aqueous ginger extracts were shown to enhance humoral immunity in humans, as demonstrated by an increased serum IgM level in non-smoker males, which may lead to a greater antibody response against infections [64]. In broilers, supplemental ginger extracts were shown to raise antibody titers against sheep red blood cells (SRBC) [65], infectious bronchitis (IB), and Newcastle disease (ND), as well as avian influenza (AI, H5N8) [66]. These results undeniably indicate that ginger and its extracts act as potential immunostimulatory agents to enhance humoral immunity during vaccination or infection.…”

Section: The Anti-inflammatory and Immunomodulatory Properties Of Gin...mentioning

confidence: 98%

Phytogenics in Ginger, Origanum vulgare, and Syzygium aromaticum and Their Potential as a Feed Additive against Clostridium perfringens in Broiler Production

Valdez,

Shyur,

Wang

et al. 2023

Animals

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Necrotic enteritis is a devastating disease in chickens mainly caused by Clostridium perfringens—particularly, Net-B toxin-producing strains. In order to combat necrotic enteritis in broiler production, natural growth promoters, as well as anti-inflammatory and non-antibiotic remedies, were developed for anti-microbial resistance due to its status as a global pandemic. Herein, phytogenic ginger, wild marjoram, and cloves were reviewed as potential alternatives to antibiotics for their anti-microbial functions. These phytogenics contain active ingredients that efficiently modulate the immune response and improve intestinal morphology and overall growth performance, even under stress and infection conditions. Most of the beneficial effects can be attributed to their anti-inflammatory functions, primarily the inhibition of the NF-κB and MAPK pathways. Phytogenics and their active ingredients represent potential substitutes for antibiotic growth promoters, further serving as anti-microbial remedies in the treatment of birds with infections.

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“…In the realm of organic constituents, noteworthy elements include terpenes and steroids, as well as sugars and amino acids, along with various flavonoids. Notable among the flavonoids are caffeic, cinnamic, p-coumaric, and chicoric acids, as well as quercetin, pinocembrin, baicalin, galangin, and chrysin, owing to their significant antiglycation [ 37 , 38 , 39 ], cardioprotective [ 40 , 41 , 42 , 43 , 44 ], neuroprotective [ 45 , 46 , 47 , 48 , 49 , 50 ], cytostatic [ 51 , 52 , 53 ], radioprotective [ 54 , 55 , 56 , 57 ], antimicrobial [ 58 , 59 , 60 , 61 , 62 , 63 ], anticancer [ 64 , 65 , 66 , 67 , 68 , 69 , 70 ], antioxidant [ 71 , 72 , 73 , 74 , 75 , 76 ], immunomodulatory [ 77 , 78 , 79 , 80 , 81 , 82 , 83 ], antidiabetic [ 84 , 85 , 86 , 87 , 88 , ...…”

Section: Propolismentioning

confidence: 99%

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Scorza,

Goncalves,

Finsterer

et al. 2024

Cells

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Aging populations worldwide are placing age-related diseases at the forefront of the research agenda. The therapeutic potential of natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular and molecular-level changes associated with age-related diseases. With this in mind, scientists have introduced a contextual framework to guide future aging research, called the hallmarks of aging. This framework encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, and altered intercellular communication. Propolis, with its rich array of bioactive compounds, functions as a potent functional food, modulating metabolism, gut microbiota, inflammation, and immune response, offering significant health benefits. Studies emphasize propolis’ properties, such as antitumor, cardioprotective, and neuroprotective effects, as well as its ability to mitigate inflammation, oxidative stress, DNA damage, and pathogenic gut bacteria growth. This article underscores current scientific evidence supporting propolis’ role in controlling molecular and cellular characteristics linked to aging and its hallmarks, hypothesizing its potential in geroscience research. The aim is to discover novel therapeutic strategies to improve health and quality of life in older individuals, addressing existing deficits and perspectives in this research area.

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Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilers

Cited by 6 publications

References 56 publications

Effects of Designed Herbal Formula on Growth Performance, Blood Indices, Organ Traits, and Cecum Microbiology in Broilers

Effects of Designed Herbal Formula on Growth Performance, Blood Indices, Organ Traits, and Cecum Microbiology in Broilers

Phytogenics in Ginger, Origanum vulgare, and Syzygium aromaticum and Their Potential as a Feed Additive against Clostridium perfringens in Broiler Production

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

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