Effects of ginger powder supplementation on glycemic status and lipid profile in newly diagnosed obese patients with type 2 diabetes mellitus

Gayar, Mohamed Hesham El; Aboromia, Maram M; Ibrahim, Nesma Ali; Hafiz, Moustafa Hussein Abdel

doi:10.1016/j.obmed.2019.100094

Cited by 26 publications

(36 citation statements)

References 19 publications

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“…In a similar trial study, where 2 g ginger was given twice daily for 8 weeks to type-2-diabetes patient, in addition to the lipid profile level, clinical attachment loss (CAL), pucket depth, plague index and bleeding on probing (BOP) showed no significant difference in the intervention group, whereas the HDL cholesterol and total antioxidant capacity increased significantly. Glycated hemoglobin, MDA, and fasting blood glucose decreased significantly [78]. The author concluded supplementation using ginger may improve glycemic control, lipid profile and antioxidant status in type-2-diabetes.…”

Section: Anti-diabetics and Anti-obesity Activity Of Z Officinalementioning

confidence: 89%

“…The glycemic status and lipid profile of obese patients with type 2-diabetes and supplemented with ginger powder improved significantly when the body mass index, fasting blood glucose, glycated hemoglobin, cholesterol, triglycerides, low density lipoprotein cholesterol, fasting insulin and insulin resistance index was observed to decrease in the patients. Additionally, highdensity lipoprotein cholesterol, beta cell functions, and insulin sensitivity index increased significantly compared to the placebo [78]. In a similar trial study, where 2 g ginger was given twice daily for 8 weeks to type-2-diabetes patient, in addition to the lipid profile level, clinical attachment loss (CAL), pucket depth, plague index and bleeding on probing (BOP) showed no significant difference in the intervention group, whereas the HDL cholesterol and total antioxidant capacity increased significantly.…”

Section: Anti-diabetics and Anti-obesity Activity Of Z Officinalementioning

confidence: 91%

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Historical, Botanical and Medicinal Perspectives on Ginger (Zingiber officinale)

Adetutu

Ifeoluwa

Olusoji

et al. 2021

JOCAMR

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Ginger is one of the most valuable culinary medicinal spice with inestimable economic uses. Because it is, a well acknowledged plant both in folkloric and advanced medicine, there are no paucity of information on the many important uses of ginger in the literature. In this review, we conveyed important details on the chemistry, pharmacology, toxicity and clinical uses of ginger. Our review of over 171 articles showed that ginger use has a worldwide coverage. Randomized clinical trial studies on ginger are most prominent on the alleviation of pregnancy-induced nausea and vomiting with fascinating outcome. In addition, the prospective use as anti-inflammatory, thrombolytic, and anti-diabetic agent were well noticed. Although the dependent on plant as source of drug in the search for disease remedy is premised on their acclaimed effectiveness and safety, available data have showed plants may possess some toxic potential, overall, our review showed that ginger might be safe with no adverse effects when investigated in normal rodent and human.

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Section: Anti-diabetics and Anti-obesity Activity Of Z Officinalementioning

confidence: 89%

Section: Anti-diabetics and Anti-obesity Activity Of Z Officinalementioning

confidence: 91%

Historical, Botanical and Medicinal Perspectives on Ginger (Zingiber officinale)

Adetutu

Ifeoluwa

Olusoji

et al. 2021

JOCAMR

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“…This study is in line with the previous results (Elrokh et al, 2010;Lebda et al, 2012;Mahmoud and Elnour, 2013). It has been any proof that ginger has pharmacological action including lipid-lowering effect because of its various components such as gingerols and shogaols (El Gayar et al, 2019). Gingerols, the primarily pungent of ginger, have the main compounds such as 6-gingerol, 8gingerol and 10-gingerol which might involve in HDL formation.…”

Section: Discussionmentioning

confidence: 99%

“…Red ginger (Zingiber officinale var rubrum) is the rhizomatous plant that has been used for culinary purpose (Oh et al, 2017). Preceding research stated that ginger had some pharmacological effects because of its various components such as gingerols and shogahols which have main roles as immunomodulatory, anticancer, antiinflammatory, anti-apoptosis, glucose and lipid-lowering effect (El Gayar et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Tempeh and red ginger flour for hypercholesterolemic rats

Dewi

Lestari

Astiningrum

et al. 2020

NFS

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Purpose This study aims to evaluate the effect of the combination of tempeh and red ginger flour in hypercholesterolemic rats. Design/methodology/approach Sprague Dawley male rats (n = 30; body weight 150-200 g) were randomly divided by five groups (n = 6), consist of negative control (K−) group: group fed by normal diet (laboratory standard diet laboratory, 4.35 kcal/g, 0% cholesterol); positive control (K+) group: group fed by high cholesterol diet (5.28 kcal/g, 12.1% cholesterol); Treatment 1 (P1) group: group fed by high cholesterol diet and treated by tempeh flour (TF) 1.9 g/200 g body weight; Treatment 2 (P2) group: group fed by high cholesterol diet and treated by red ginger flour (RGF) 0.036 g/200 g body weight; and Treatment 3 (P3) group: group fed by high cholesterol diet and treated by a combination TF 0.95 g/200 g body weight and red ginger 0.018 g/200 g body weight. The lipid profiles and malondialdehyde (MDA) were assessed. Findings The combination of tempeh and red ginger has successfully exerted the total cholesterol (121.9 ± 3.41 mg/dL; p < 0.01), triglycerides (TG) (89.3 ± 2.94 mg/dL; p < 0.01), low-density lipoprotein (39.1 ± 1.59 mg/dL) and MDA (2.0 ± 0.24 mg/dL; p < 0.01) lower than the other treatments. Also, the combination of tempeh and red ginger treatment appeared the highest high-density lipoprotein concentration (63.4 ± 2.26 mg/dL; p < 0.01) compared to the other treatment groups. Total cholesterol and TG were predicted as the increasing of MDA concentration. Originality/value The combination treatments successfully improved the lipid profiles and MDA. Furthermore, the combination of tempeh and red ginger could be effective in supporting therapy as the hypolipidemic condition.

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“…The study also found a significant increase in beta-cell function index (HOMA2-%β), insulin sensitivity index (HOMA2-%S), as well as high-density lipoprotein cholesterol levels in the ginger group compared to placebo. The authors concluded that ginger supplements could be used as an adjuvant therapy to improve the efficacy of type 2 diabetes mellitus treatment (El Gayar et al, 2019).…”

Section: Clinical Studiesmentioning

confidence: 99%

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

et al. 2021

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Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism, stomach ache, and urinary tract infections. To date, over 400 bioactive components, such as diarylheptanoids, gingerol analogues, phenylalkanoids, sulfonates, monoterpenoid glycosides, steroids, and terpene compounds have been derived from ginger. Increasing evidence has revealed that ginger possesses a broad range of biological activities, especially protective effects against male infertility, nausea and vomiting, analgesic, anti-diabetic, anti-inflammatory, anti-obesity, and other effects. The pharmacological activities of ginger were mainly attributed to its active phytoconstituents such as 6-gingerol, gingerdiol, gingerol, gingerdione, paradols, shogaols, sesquiterpenes, zingerone, besides other phenolics and flavonoids. In recent years, in silico molecular docking studies revealed that gingerol (6-gingerol, 8-gingerol, and 10-gingerol) and Shogaol (6-shogaol, 8-shogaol, 10-shogaol) had the best binding affinities to the receptor protein in disease conditions such as diabetes, inflammation, obesity, and SARS-CoV-2. Furthermore, some clinical trials have indicated that ginger can be consumed for alleviation of nausea and vomiting induced by surgery, pain, diabetes, obesity, inflammation, male infertility. This review provides an updated understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.

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Effects of ginger powder supplementation on glycemic status and lipid profile in newly diagnosed obese patients with type 2 diabetes mellitus

Cited by 26 publications

References 19 publications

Historical, Botanical and Medicinal Perspectives on Ginger (Zingiber officinale)

Historical, Botanical and Medicinal Perspectives on Ginger (Zingiber officinale)

Tempeh and red ginger flour for hypercholesterolemic rats

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

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