1958
DOI: 10.1210/jcem-18-8-813
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Effects of Glucagon on Renal Function in Man*

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Cited by 68 publications
(18 citation statements)
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“…Figure I demonstrates the changes in plasma glucagon and kidney function produced by the infusion of Elrick et al [3] showed that glucagon (0.9-7.5 trig) administered as a single dose intramuscularly or intravenously, or as a continuous intravenous infusion, increased GFR and RPF by approximately 10-15 per cent in normal man. Butturini et al [1] found an increase of about 10 per cent in GFR and RPF, giving a single intravenous injection of 1 to 3 mg glucagon in normal man.…”
Section: Resultsmentioning
confidence: 99%
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“…Figure I demonstrates the changes in plasma glucagon and kidney function produced by the infusion of Elrick et al [3] showed that glucagon (0.9-7.5 trig) administered as a single dose intramuscularly or intravenously, or as a continuous intravenous infusion, increased GFR and RPF by approximately 10-15 per cent in normal man. Butturini et al [1] found an increase of about 10 per cent in GFR and RPF, giving a single intravenous injection of 1 to 3 mg glucagon in normal man.…”
Section: Resultsmentioning
confidence: 99%
“…Enhanced GFR has been demonstrated in animals and man during glucagon infusion in pharmacological doses [1, 3,7]. Therefore, glucagon might be involved in the pathogenesis of the kidney function alterations in diabetes.…”
mentioning
confidence: 99%
“…Plasma glucagon concentration increases during fasting and decreases during refeeding (21,22). Since glucagon is known to have natriuretic properties (23)(24)(25)(26), sodium retention during refeeding could be related, at least in part, to a reduction in plasma glucagon concentration. However, carbohydrate-stimulated insulin secretion is also temporally related to sodium retention, and one may reasonably raise the question whether insulin plays a role in this phenomenon.…”
Section: Introductionmentioning
confidence: 99%
“…The observations reviewed in this paper show that cAMP should no longer be regarded only as an intracellular second messenger but also as a first messenger responsible for coordinated hepatorenal functions, and possibly for paracrine regulations in several other tissues. Dictyostelium discoideum; liver; adipose tissue; glucagon; epinephrine; parathyroid hormone; insulin; hypertension; hepatorenal syndrome; diabetes mellitus; sodium; phosphate GLUCAGON, A PANCREATIC HORMONE secreted after ingestion of proteins, has been known for a long time to be natriuretic and phosphaturic (56,66,105,142) and to increase renal blood flow and glomerular filtration rate …”
mentioning
confidence: 99%