Effects of glucocorticoids and mineralocorticoids on proliferation and maturation of human peripheral blood stem cells

Grafte-Faure, Stéphanie; Leveque, Catherine; Vasse, Marc; Soria, Claudine; Norris, Victor; Vannier, Jean‐Pierre

doi:10.1002/(sici)1096-8652(199910)62:2<65::aid-ajh1>3.3.co;2-7

Cited by 7 publications

(5 citation statements)

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“…Additionally, there was a negative correlation between CPC functionality and cortisol z ‐score (Table ), underscoring the influence of ultra‐endurance exercise‐induced stress on CPC function. In the light of these results, we raise the hypothesis that either the cellular composition of the hematopoietic stem and progenitor fraction in the peripheral blood changed or that the ultra‐endurance exercise‐induced metabolic stress and inflammatory response have a direct negative effect on the survival, differentiation and/or functionality of CPCs (Grafte‐Faure et al., ; Schraml et al., ; Penn et al., ; Kröpfl et al., ; Kröpfl et al., ). Since catecholamines and MMP‐9 are known to mobilize CPCs out of the bone marrow, the second hypothesis is that the bone marrow is not able to respond to the long‐lasting stimulus because of exhaustion.…”

Section: Discussionmentioning

confidence: 89%

Ultra‐endurance exercise induces stress and inflammation and affects circulating hematopoietic progenitor cell function

Stelzer

Kröpfl

Fuchs

et al. 2014

Scandinavian Med Sci Sports

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Although amateur sports have become increasingly competitive within recent decades, there are as yet few studies on the possible health risks for athletes. This study aims to determine the impact of ultra-endurance exercise-induced stress on the number and function of circulating hematopoietic progenitor cells (CPCs) and hematological, inflammatory, clinical, metabolic, and stress parameters in moderately trained amateur athletes. Following ultra-endurance exercise, there were significant increases in leukocytes, platelets, interleukin-6, fibrinogen, tissue enzymes, blood lactate, serum cortisol, and matrix metalloproteinase-9. Ultra-endurance exercise did not influence the number of CPCs but resulted in a highly significant decline of CPC functionality after the competition. Furthermore, Epstein-Barr virus was seen to be reactivated in one of seven athletes. The link between exercise-induced stress and decline of CPC functionality is supported by a negative correlation between cortisol and CPC function. We conclude that ultra-endurance exercise induces metabolic stress and an inflammatory response that affects not only mature hematopoietic cells but also the function of the immature hematopoietic stem and progenitor cell fraction, which make up the immune system and provide for regeneration.

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Section: Discussionmentioning

confidence: 89%

Ultra‐endurance exercise induces stress and inflammation and affects circulating hematopoietic progenitor cell function

Stelzer

Kröpfl

Fuchs

et al. 2014

Scandinavian Med Sci Sports

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“…In avian erythroid progenitors, steroid hormones cooperate with tyrosine kinase receptors to induce and sustain proliferation of erythroid progenitors (30, 31). However, a different effect of glucocorticoids on CD34+ human peripheral blood stem cells was reported whereby inhibition of the erythroid and granulocyte‐macrophage proliferation was found when triamcinolone was added to CD34+ cell culture (32). In vivo studies on the effect of steroids on EPO gene regulation in humans are not available.…”

Section: Oral Corticosteroid Therapymentioning

confidence: 99%

Anemia in children after transplantation: etiology and the effect of immunosuppressive therapy on erythropoiesis

Al‐Uzri

Yorgin

Kling

2003

Pediatric Transplantation

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Anemia in children after renal transplantation is more common than previously appreciated. Multiple factors appear to play roles in the development of post-transplant anemia, the most common of which is absolute and/or functional iron deficiency anemia. Most experts recommend that iron limited anemias in transplant patients should be diagnosed using the same criteria as for chronic renal failure patients. Serum erythropoietin (EPO) levels are expected to normalize after a successful renal transplantation with a normal kidney function, yet both EPO deficiency and resistance have been reported. While no large controlled trials comparing the effect of different immunosuppressive agents on erythropoiesis after transplantation have been performed, generalized bone marrow suppression attributable to azathioprine (AZA), mycophenolate mofetil (MMF), tacrolimus, antithymocyte preparations has been reported. Pure red cell aplasia (PRCA) occurs rarely after transplantation and is characterized by the selective suppression of erythroid cells in the bone marrow. PRCA has been reported with the use of AZA, MMF, tacrolimus, angiotensin converting enzyme inhibitors (ACEI), but not with cyclosporine (CSA) use. Post-transplant hemolytic uremic syndrome has been reported with orthoclone anti T-cell antibody (OKT3), CSA and tacrolimus therapy. Viral infections including cytomegalovirus, Epstein-Barr virus and human parvovirus B19 have been reported to cause generalized marrow suppression. Management of severe anemia associated with immunosuppressive drugs generally requires lowering the dose, drug substitution or, when possible, discontinuation of the drug. Because this topic has been incompletely studied, our recommendation as to the best immunosuppressive protocol after renal transplantation remains largely dependent on the clinical response of the individual patient.

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“…Because the affinity of the MR for corticosterone is much higher as compared to the GR it is assumed for the hippocampus that corticosterone at basal levels acts through the MR while at elevated concentrations it additionally binds to the GR 5 . Interestingly, MR expression in leucocytes has not yet been reported with the exception of human CD34 + haematopoietic progenitor cells 6 and rat microglial cells, 7 a macrophage‐related cell‐type that resides in the central nervous system. In the latter case, it was suggested that the MR mediates immunostimulatory effects at low corticosterone concentrations whilst immunosuppressive GC effects at high doses are conferred through the GR.…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

et al. 2007

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SummaryGlucocorticoids (GCs) are involved in the modulation of macrophage function and thereby control the host's immune responses to pathogens. However, neither the role of hormone concentration nor the differential contribution of the glucocorticoid (GR) and the mineralocorticoid receptors (MR) to these activities are known. Here we show that low levels of corticosterone enhance NO production as well as mRNA expression of pro-inflammatory cytokines, chemokines and enzymes required for mediator synthesis. In contrast, at high corticosterone concentrations macrophage function was strongly repressed. Importantly, inactivation of the GR by lentiviral delivery of siRNAs abrogated both the immunostimulatory and the immunosuppressive GC actions whereas inactivation of the MR had no effect. Furthermore, removal of endogenous GCs by adrenalectomy in vivo induced a preactivated state in macrophages that could be modulated by corticosterone. We conclude that GCs exert distinct effects on macrophage function dependent on their concentration, and that they primarily act through the GR despite concomitant expression of the MR.

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Effects of glucocorticoids and mineralocorticoids on proliferation and maturation of human peripheral blood stem cells

Cited by 7 publications

References 0 publications

Ultra‐endurance exercise induces stress and inflammation and affects circulating hematopoietic progenitor cell function

Ultra‐endurance exercise induces stress and inflammation and affects circulating hematopoietic progenitor cell function

Anemia in children after transplantation: etiology and the effect of immunosuppressive therapy on erythropoiesis

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

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