Effects of glucocorticoids on apoptosis of infiltrated eosinophils and neutrophils in rats

Nittoh, Takeaki; Fujimori, Hiroaki; Kozumi, Yoshiko; Ishihara, Kenji; Mue, Suetsugu; Ohuchi, Kazuo

doi:10.1016/s0014-2999(98)00426-9

Cited by 61 publications

(54 citation statements)

References 39 publications

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“…Furthermore, since glucocorticoids directly induce apoptosis in eosinophils, the effects of dead and dying cells on macrophages could be amplified and prolonged in time. 50 While these considerations are speculative, they nevertheless suggest the possibility that the effects of glucocorticoids on macrophage number and function may be indirect and result from downstream effects in other cell populations.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dexamethasone on the Generation of Plasma DNA from Dead and Dying Cells

Jiang

Pisetsky

2004

The American Journal of Pathology

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Section: Discussionmentioning

confidence: 99%

The Effect of Dexamethasone on the Generation of Plasma DNA from Dead and Dying Cells

Jiang

Pisetsky

2004

The American Journal of Pathology

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“…These results suggest that mechanisms of redistribution of eosinophils and basophils are different from those of the neutrophils and monocytes under these experimental conditions, indicating that physiological significances of eosinophils and basophils during various endogenous stimuli would be different from those of other granulocytes. For example, glucocorticoids are reported to enhance eosinophil apoptosis but inhibit neutrophil apoptosis in rats (42). Although the administration of CLE induces β-adrenergic promotion of arterial shearing force, the circulating number of eosinophils clearly decreased.…”

Section: Cle Administration-induced Distribution Changes Of Wbcsmentioning

confidence: 99%

β2-Agonist Clenbuterol Induced Changes in the Distribution of White Blood Cells in Rats

et al. 2007

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Abstract. Clenbuterol [CLE: 4-amino-α(t-butyl-amino)methyl-3,5-dichlorobenzyl alcohol] is well known as a potent β 2 -adrenergic agonist and non-steroidal anabolic drug, and thus it is generally used for sports doping and asthma therapy. Although the functions of immune cells such as white blood cells (WBCs) have shown to be modulated through β 2 -adrenoceptors, the effects of CLE on immune-responsive systems have not been elucidated systematically. Therefore, the effects of CLE on the number of WBCs were studied in rats. Male adult rats were divided into CLE-administered group and the control group to compare the number of total WBCs, neutrophils, monocytes, lymphocytes, eosinophils, and basophils. The administration (dose = 1.0 mg ⋅ kg −1 body weight ⋅ day −1 , s.c.) of CLE was maintained for 30 days. CLE did not change the number of total WBCs during the experimental period. However, CLE increased significantly the number of neutrophils and monocytes, while CLE decreased drastically the number of lymphocytes and eosinophils. There was no significant change in the number of basophils between both groups. These results suggest that the administration of CLE induces drastic redistribution of WBCs in circulation without changing the number of total WBCs, and these responses of WBCs during the administration of CLE are sustained for at least 30 days.

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“…7,8) Physical exercise is also associated with changes in neuroendocrine and immune functions, 5) and it can affect host defense mechanisms including the number of circulating granulocytes and secretory immunoglobulin levels. [9][10][11] However, these induced changes are small in magnitude and brief in duration, and their physiological significance is uncertain. [5][6][7][8][9][10][11] Therefore, a greater understanding of stress-induced immunesuppression derived from social and/or physical activity is needed.…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11] However, these induced changes are small in magnitude and brief in duration, and their physiological significance is uncertain. [5][6][7][8][9][10][11] Therefore, a greater understanding of stress-induced immunesuppression derived from social and/or physical activity is needed. [12][13][14] Conditions leading to reduced physical activity and decreased mechanical muscle loading induce changes in the responses of physiological host defense systems including the hypothalamophpophyseal-adrenocortical axis, the sympathetic nervous system and the immune system.…”

Section: Introductionmentioning

confidence: 99%

Acute and Subacute Effects of Dexamethasone on the Number of White Blood Cells in Rats

Ohkaru

Arai

Ohno

et al. 2010

JOURNAL OF HEALTH SCIENCE

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The purpose of this study was to elucidate the effects of dexamethasone, a synthetic glucocorticoid, on the immune system by analyzing the number of white blood cells (WBCs) over the course of hours and days of dexamethasone administration. Dexamethasone was given as either a single dosage [1.0 mg/kg body weight (BW); subcutaneous injection (s.c.)] or as a daily dosage (1.0 mg/kg BW per day; s.c.) for 10 days for the hourly and daily assessment of changes in the number of white blood cells, respectively. A single administration of dexamethasone markedly decreased the number of total WBCs, as well as the number of lymphocyte, monocyte, neutrophil and eosinophil subsets with a nadir at 8 hr post-injection. The number of these cells recovered to the control levels at 24 hr. The numbers of total WBCs, lymphocytes, monocyte, eosinophil and basophil were reduced by the daily administration of dexamethasone. However, the number of neutrophil was significantly higher at days 2 and 8 after the injection. These results suggest that glucocorticoid-mediated immunosuppressions are at least partly attributable to quantitative changes in the number of circulating WBCs.

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Effects of glucocorticoids on apoptosis of infiltrated eosinophils and neutrophils in rats

Cited by 61 publications

References 39 publications

The Effect of Dexamethasone on the Generation of Plasma DNA from Dead and Dying Cells

The Effect of Dexamethasone on the Generation of Plasma DNA from Dead and Dying Cells

β2-Agonist Clenbuterol Induced Changes in the Distribution of White Blood Cells in Rats

Acute and Subacute Effects of Dexamethasone on the Number of White Blood Cells in Rats

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