Effects of glucose on fuel utilization and glycerol turnover in normal and injured man

Some aspects of the metabolic response to surgical trauma

“…Amino acids released from the breakdown of lean tissue protein are also important precursors for gluconeogenesis, and there is a glucose-alanine cycle analogous to the glucose-lactate cycle. Another so-called futile cycle involves lipolysis and reesterification of fatty acids, and the activity of this cycle is increased by 450 % in burned patients (Wolfe et al 1987); similar increases have been reported in injured and septic patients (Jeevanandam et al 1990).…”

“…The respiratory exchange ratio in injured patients is consistently lower than normal for a given level of intake (Jeevanandam et al 1990), indicating a greater rate of fat oxidation. Thus, fat oxidation provides the energy to drive the gluconeogenic cycles and the lipolysis-re-esterification cycle.…”

“…Thus, fat oxidation provides the energy to drive the gluconeogenic cycles and the lipolysis-re-esterification cycle. Infusion of glucose in amounts which lead to net synthesis of fat in normal volunteers or depleted controls fails to suppress fat oxidation in injured and septic patients, leaving them in negative fat balance (Gil et al 1985;Jeevanandam et al 1990).…”

Die parenterale ErnährungstherapieEnergetische und nicht-energetische Wirkungen von Kohlenhydraten und Fetten

“…einer Verbrennung muß man zwar bei einer Zufuhr bis zu 4 mg/kg/min Glukose oder umgerechnet etwa 400 g Glukose pro Tag mit einem Anstieg des Blutzuckers rechnen [33,71,72]. Nach Laparotomie, einem Trauma bzw.…”