Effects of Glucose on Scopolamine-Induced Learning Deficits in Rats Performing the Morris Water Maze Task

Okaichi, Yoko; Okaichi, Hiroshige

doi:10.1006/nlme.1999.3940

Cited by 10 publications

(4 citation statements)

References 52 publications

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“…The results obtained 28 days after the acquisition phase corroborate previously reported data (Okaichi andOkaichi 2000, Wallenstein andVago 2001) about the effects of scopolamine since that the performance of the control animals was impaired by this drug. However, the malnourished animals were not impaired by drug treatment, suggesting longlasting functional changes of the cholinergic system in these animals.…”

Section: Discussionsupporting

confidence: 93%

“…The absence of significant differences in locomotor activity or exploration (rearing) assures that the present data were not affected by these factors. In addition, Okaichi and Okaichi (2000) confirmed that in spatial navigation tasks in the Morris water maze, the sensorimotor system or motivational factors are not affected by scopolamine.…”

Section: Discussionsupporting

confidence: 77%

“…Drug effects have been reported to occur only when the drug is administered before the beginning of the task (Whishaw and Petrie 1988), with no effect on learning consolidation. Others have reported that the action of the drug during the consolidation period is effective (Okaichi andOkaichi 2000, Wallenstein andVago 2001), not only in tasks performed in the Morris maze but also in other experimental models. The results of the present study confirm that scopolamine treatment impairs both the acquisition and the consolidation of spatial information, as evidenced by the results for the control group in Experiments 1 and 2.…”

Section: Discussionmentioning

confidence: 97%

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Effects of early protein malnutrition and scopolamine on learning and memory in the Morris water maze

Fukuda

Françolin-Silva

Hernandes

et al. 2007

Nutritional Neuroscience

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The present study investigated the effects of early protein malnutrition on the spatial learning and memory processes. The consequences of malnutrition for the cholinergic system were evaluated by comparing the performance of malnourished and control animals in the Morris water maze after treatment with scopolamine. The learning test consisted of placing the animal in the maze to escape to a submerged platform with 12 trials per day for two consecutive days. After 24 trials, the platform was removed, the rats were placed in the maze and the time spent by them in each quadrant was recorded. After 28 days the animals were tested in a single trial to verify the retention of the spatial information. In the first Experiment, scopolamine (0.0, 0.2, 0.4 and 0.6 mg/kg per ml. i.p.) was administered 20 min before the experimental sessions. In the second experiment, a dose of 0.6 mg/kg was administered after the sessions, during the period in which learning consolidation occurs. In the first experiment, there was a significant effect of the drug, with scopolamine impairing, learning in both nutritional conditions. In the saline condition, control animals presented a better performance when compared with malnourished animals. However, 28 days later, both groups increased their latencies. With 0.2 and 0.4 mg/kg of scopolamine, the performance of both nutritional groups was similar and with 0.6 mg/kg malnourished animals performed better than controls. In the second experiment, malnourished animals were also less reactive to the effects of scopolamine, resulting in lower impairments as compared to control animals. These data suggest long-term changes in learning and memory as the result of changes produced by protein malnutrition in the cholinergic neurotransmitter system.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Effects of early protein malnutrition and scopolamine on learning and memory in the Morris water maze

Fukuda

Françolin-Silva

Hernandes

et al. 2007

Nutritional Neuroscience

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“…The procedure for the water maze place task has been described previously (see Okaichi & Okaichi, 2000). In brief, the pool was divided into four quadrants (NE, NW, SE, SW), and the escape platform was placed in the center of one of the quadrants.…”

Section: Methodsmentioning

confidence: 99%

Effects of arachidonic acid on the spatial cognition of aged rats

Okaichi¹,

Okaichi²,

Akimoto³

et al. 2006

Jpn Psychol Res

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To examine the effects of arachidonic acid (AA) on age-related cognitive deficits, Fischer 344 rats were given an AA-supplemented powder diet for 12 weeks from 18.6 months old as part of the old AA (OA) group. Other age-matched rats were fed a non-AA-supplemented powder diet as part of the old control (OC) group, and young rats were fed lab pellets as part of the young control (YC) group. When the aged rats reached 20.0 months old, all animals were tested for spontaneous activity in an open field, followed by the Morris water maze place and cue tasks. Escape latencies for the place task showed that the YC rats were fastest, and there was no difference between the OA and OC groups. However, the probe test and the first block of the cue task indicated that the OA rats remembered the location of an invisible platform better than the OC rats. Although the amount of hippocampal AA was larger in the OA rats than in the OC rats, the difference was not significant. The results showed that AA administration to aged animals may alleviate age-related deficits in spatial cognition.

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Neurochemical Changes Observed by In Vivo Proton Magnetic Resonance Spectroscopy in the Mouse Brain Postadministration of Scopolamine

Woo

Lenkinski

2014

Academic Radiology

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Effects of Glucose on Scopolamine-Induced Learning Deficits in Rats Performing the Morris Water Maze Task

Cited by 10 publications

References 52 publications

Effects of early protein malnutrition and scopolamine on learning and memory in the Morris water maze

Effects of early protein malnutrition and scopolamine on learning and memory in the Morris water maze

Effects of arachidonic acid on the spatial cognition of aged rats

Neurochemical Changes Observed by In Vivo Proton Magnetic Resonance Spectroscopy in the Mouse Brain Postadministration of Scopolamine

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