Effects of glutamine on cytokines 1L‑1 and TNF‑α in rehabilitation and prognosis of patients with lobectomy

Wang, Xuefeng; Huang, Lei; Qu, Yanghua; Lv, Hongmei; He, Xiaohua

doi:10.3892/etm.2018.6443

Cited by 4 publications

(5 citation statements)

References 27 publications

(26 reference statements)

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“…Arginine supplementation only showed that topical administration did not affect IL-10 production in mice with laparotomy ( Jeronimo et al , 2016 ). In Contrary, several studies showed that glutamine only affects the high production of IL-10 in lobectomy patients ( Wang et al , 2018 ) and in bone marrow-derived macrophages induced by LPS ( de Oliveira et al , 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines

Maulydia¹,

Rehatta²,

Sudarmo³

2023

Open Vet J

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Background: Cytokines were beneficial for diagnosis and treatment, which in clinical situations introduced from the perspective of pro and anti-inflammatory effects. An inflammatory response is commonly associated with various severe traumatic insults that consequently recruit the immune cells into the target organs and causing systemic inflammatory response that can lead to sepsis. Immune-modulating nutrients, such as glutamine and arginine, are known as pathophysiological modulate in inflammation. Aim: The aim of this study was to evaluate the effect of oral gavage supplementation with a combination of glutamine and arginine on inflammatory cytokines in intestinal mucosa, specifically jejunum. Methods: Sixteen Rattus norvegicus rats (average weight 150–200 g) were randomly divided into two groups: groups A and B, both intraperitoneal injected by 2 ml NaCl 0.9%. Group A orally supplemented with 1 ml dextrose 5% daily, meanwhile, group B orally supplemented with 1 ml combination of glutamine and arginine (contains 250 mg/kg glutamine and 250 mg/kg arginine) daily. The experiment lasted for 3 days. We compared the pro and anti-inflammatory cytokines (IL-10, NF-κB, TNF-α, IL-8, and MMP-8) between the two groups by the Mann–Whitney test. Results: More IL-10, TNF-α, and IL-8 cytokine-produced cells found in group A. Group B produced significantly lower TNF-α ( p = 0.009) and IL-8 ( p = 0.003). The number of NF-κB and MMP-8 were slightly higher in group B. Conclusion: Giving a combination of glutamine and arginine as nutrition supplementation has beneficial effects in decreasing almost half of the cells that produce TNF-α and IL-8. Further studies must be carried out to support a standard guideline for this recommendation.

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Section: Discussionmentioning

confidence: 99%

Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines

Maulydia¹,

Rehatta²,

Sudarmo³

2023

Open Vet J

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“…Previous studies indicated that Gln protected cells against oxidative stress by scavenging free radicals (X. H. Zhou, Wu, et al, 2012). Gln is a precursor for synthesis of glutathione (GSH) which is the most important antioxidant and free radical scavenger (M. H. Kim & Kim, 2017; X. Y. Wang et al, 2018). Furthermore, GSH‐Px can specifically catalyse GSH to scavenge oxygen free radicals and protect cells against oxidative stress (Aquilano et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of sodium humate and glutamine on growth performance, diarrhoea incidence, blood parameters, and faecal microflora of pre‐weaned calves

Wang

Jia

et al. 2022

Animal Physiology Nutrition

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This study aimed to evaluate the effects of administration of sodium humate (HNa) and glutamine (Gln) on growth performance, diarrhoea incidence, serum parameters, and faecal microflora of pre-weaned Holstein calves. In a 57-day experiment, 28 healthy newborn female calves were randomly allocated to four treatment groups: (1) CON (control); (2) HNa (basal diet + 5% HNa); (3) Gln (basal diet + 1% Gln); and (4) HNa + Gln (basal diet + 5% HNa + 1% Gln). The calves in the CON group were fed with basal diet.HNa and Gln were alone or together mixed with milk (Days 1-20) or milk replacer (Days 21-57) and orally administered to each calf. The results indicated that calves combined supplemented with HNa and Gln had a higher average daily gain at 0-21 days, 21-57 days, and 0-57 days, and starter intake at 21-57 days and 0-57 days (p < 0.05).Compared with the CON group, calves in HNa, Gln, and HNa + Gln groups showed lower faecal scores and diarrhoea incidence at 0-21 days and 0-57 days (p < 0.05). Combined administration of HNa and Gln increased the concentration of IgG and IgA, activities of glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC) but decreased the concentration of diamine oxidase (DAO), D-lactic acid (D-lac), TNF-α, and malondialdehyde (MDA) in the serum of calves compared with the CON group throughout the entire period (p < 0.05). Furthermore, the abundances of Bifidobacterium and Lactobacillus were increased but the Escherichia coli was decreased in faecal grab samples of HNa + Gln group calves in comparison with the CON group (p < 0.05). In conclusion, combined administration of HNa and Gln effectively improved the growth performance, antioxidant and immune status, and intestinal beneficial bacteria, and further reduced the diarrhoea incidence of the pre-weaned calves.

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“…In contrast, several publications observed an increase in Th1 cytokines (IL-2 and IFN-γ) in PMACI-treated intestinal intraepithelial lymphocytes by glutamine 33 . Similarly, IL-1 and IL-10 were upregulated in glutamine-treated lobectomy patients 32 . Other supplements, such as sodium pyruvate in IMDM, have been shown to impair cytokine production by inhibiting inflammatory signalling pathways 34 .…”

Section: Cell Source and Culture Conditions Of Hmc-1 Cell Linementioning

confidence: 91%

“…Coëffier et al (2001) demonstrated the reduction in pro-inflammatory cytokines (IL-6 and IL-8) from human intestinal mucosa by glutamine via a post-transcriptional pathway 30 . Glutamine has also decreased the expression of leukotriene C 4 , monocyte chemoattractant protein (MCP), macrophage inflammatory protein (MIP)-1β, tumor necrosis factor alpha (TNF-α), interleukin (IL)-15, and IL-18 in human intestinal mast cells, and lobectomy patients 31,32 . In contrast, several publications observed an increase in Th1 cytokines (IL-2 and IFN-γ) in PMACI-treated intestinal intraepithelial lymphocytes by glutamine 33 .…”

Section: Cell Source and Culture Conditions Of Hmc-1 Cell Linementioning

confidence: 99%

Current Utilization Trend of Mast Cell Lines in In Vitro Allergy Research: A Systematic Review

Yip,

Lee,

Kow

et al. 2024

Preprint

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Today in the modern world, allergic diseases, also described as atopic allergies, are classified as a type of multifactorial disorder due to the complex interplay between genetics, environment, and socioeconomic factors that influence the disease’s manifestation, severity, and one’s predisposition to allergic diseases. It is undeniable that many reported studies have pointed out that the mast cell is one of the main key players involved in triggering an allergic reaction. In order to improve our current understanding of the molecular and cellular mechanisms underlying allergy, various mast cell lines have been employed in vitro to study the pathogenesis of allergic diseases for the past decades. However, there is no consensus on many fundamental aspects associated with their use, such as the effects of culture media composition and the type of inducer used for cell degranulation. As the standardization of research protocols and disease models is crucial, we hereby present the outcome of a systematic review of scientific articles that used three major in vitro mast cell lines (HMC-1, LAD2, and RBL-2H3) to study allergy. This systematic review described the cell source, culture conditions, inducers used for degranulation, and mediators released for examination. We hope that the present systematic review may help to standardize the use of in vitro mast cell lines in allergy research and serve as a user’s guide to understand the fundamental aspects of allergy as well to develop an effective allergy therapy in the future for the betterment of human good health and wellbeing.

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Effects of glutamine on cytokines 1L‑1 and TNF‑α in rehabilitation and prognosis of patients with lobectomy

Cited by 4 publications

References 27 publications

Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines

Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines

Effects of sodium humate and glutamine on growth performance, diarrhoea incidence, blood parameters, and faecal microflora of pre‐weaned calves

Current Utilization Trend of Mast Cell Lines in In Vitro Allergy Research: A Systematic Review

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