Effects of Glycerol Test on Resonance Frequency in Patients with Ménière’s Disease

Öz, Işılay; Hızal, Evren; Çam, Osman Halit; Özlüoğlu, Levent N.

doi:10.1159/000503845

Cited by 3 publications

(13 citation statements)

References 27 publications

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“…The two groups seem to be comparable regarding RF (Mdiff = −42.5, 95% CI: [−102.5]–[17.4], I 2 = 0.66%). The same measurement between affected ears and control ears was also reported in four studies [ 27 , 28 , 30 , 31 ] with a total of 521 ears (AE n = 205, CE n = 316). The results show no statistically significant differences between the two groups (Mdiff = −106.6, 95% CI: [−219.3]–[6.0], I 2 = 77%).…”

Section: Resultssupporting

confidence: 66%

“…Ultimately, seven studies reported a total of 899 ears, 282 of which were affected by Ménière’s disease, 197 were unaffected ears, and 420 were control ears. Four of them were conducted in Japan [ 26 , 27 , 28 , 29 ], one of them in France [ 30 ], and one in Turkey [ 31 ] and the Netherlands, respectively [ 32 ]. All seven studies had a prospective cohort design.…”

Section: Resultsmentioning

confidence: 99%

“…The resonant frequency is the frequency of minimum resistance and maximum amplitude in a vibratory system. A comparison of RF in affected and unaffected ears is reported in five studies [ 27 , 28 , 29 , 30 , 31 ] with a total of 359 ears (AE n = 205, UE n = 154). The two groups seem to be comparable regarding RF (Mdiff = −42.5, 95% CI: [−102.5]–[17.4], I 2 = 0.66%).…”

Section: Resultsmentioning

confidence: 99%

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Can Multifrequency Tympanometry Be Used in the Diagnosis of Meniere’s Disease? A Systematic Review and Meta-Analysis

Tsilivigkos,

Vitkos,

Ferekidis

et al. 2024

JCM

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(1) Background: Ménière’s disease (MD) is a disease of the inner ear, presenting with episodes of vertigo, hearing loss, and tinnitus.The aim of this study is to examine the role of multifrequency tympanometry (MFT) in the diagnosis of MD. (2) Methods: A systematic review of MEDLINE (via PubMed), Scopus, Google Scholar, and the Cochrane Library was performed, aligned with the PRISMA guidelines. Only studies that directly compare ears affected by Ménière’s disease with unaffected or control ears were included. Random-effects model meta-analyses were performed. (3) Results: Seven prospective case-control studies reported a total of 899 ears, 282 of which were affected by Ménière’s disease (affected ears—AE), 197 unaffected ears in patients with MD (UE), and 420 control ears (CE) in healthy controls. No statistically significant differences between the groups were observed regarding resonant frequency (RF). The pure tone audiometry average of the lower frequencies (PTA basic) was significantly greater in affected ears when compared with unaffected ears. The conductance tympanogram at 2 kHz revealed a statistically significantly greater G width of 2 kHz in the affected ears when compared to both unaffected and control ears, while control ears had a statistically significant lesser G width of 2 kHz compared to both the other two groups. (4) Conclusions: MFT, and specifically G width at 2 kHz, could be an important tool in the diagnosis of MD.

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Section: Resultssupporting

confidence: 66%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Can Multifrequency Tympanometry Be Used in the Diagnosis of Meniere’s Disease? A Systematic Review and Meta-Analysis

Tsilivigkos,

Vitkos,

Ferekidis

et al. 2024

JCM

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“…We did not analyse the RF in our population since previous results are very conflicting. Moreover, the RF decreased during the glycerol test in a study by Oz et al from 2019[Oz et al, 2019. The glycerol test is a dehydration test used in the diagnosis of MD.…”

Section: Discussionmentioning

confidence: 95%

The Diagnostic Value of Multifrequency Tympanometry in Patients with Ménière’s Disease: A Prospective Analysis

Esch

Benthem

et al. 2023

Audiol Neurotol

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Introduction: Diagnosing Ménière’s disease (MD) by its characteristics such as episodes of vertigo, fluctuating hearing loss, and tinnitus with aural fullness remains challenging. Available tests evaluating the presence of endolymphatic hydrops (EH) are often expensive or time assuming. An in-office quick and simple non-invasive diagnostic test is multifrequency tympanometry (MFT). It can measure conductance at 2 kHz probe tones, which was demonstrated to reflect variations in cochlear pressure. Previous studies investigating MFT as a diagnostic test for MD showed conflicting outcomes possibly biased by their retrospective design. Methods: We prospectively collected MFT results (Y width) in patients with dizziness and compared MFT test results in affected (group 1) and unaffected (group 2) ears of 37 MD subjects and in control ears of 33 non-MD subjects (group 3). Results: The mean value of the Y width in affected ears was 315.6 ± 70.2 daPa compared to 292.3 ± 98.6 daPa in unaffected ears in MD subjects and 259.4. ± 60.6 daPa in the non-MD group. A positive test result (i.e., a Y width of 235 daPa or more) was found in 35 ears in the MD group, 21 times involving the affected ear and 14 times involving the unaffected ear, compared to 16 in the non-MD group. No significant differences between the three groups could be demonstrated (p > 0.05). We found a sensitivity of 58.3% and specificity of 66.3% for detecting EH in an affected ear in MD subjects. Conclusion: There is a trend towards increased conductance tympanometry in affected ears. However, we noticed a high false positive rate of MFT and do not support standardized use of MFT as an additional diagnostic tool for detecting EH in MD patients. A negative test result on the contrary is unlikely related to EH.

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“…RF is the frequency with the lowest resistance and the highest vibration of the middle ear system and is affected by changes in mass and hardness occurring in the middle ear mechano-acoustic system. 6 …”

Section: Introductionmentioning

confidence: 99%

The Effect of Postmenopausal Osteoporosis on Middle Ear Resonance Frequency

Baytaroglu¹,

Jafarov²,

Erbek³

2021

Int Adv Otol

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Background: The effect of postmenopausal osteoporosis on the middle ear mechano-acoustic system is unknown. The aim of this study is to investigate whether or not middle ear resonance frequency is affected in females with postmenopausal osteoporosis. Methods: The study included postmenopausal women aged 45-60 years, separated into 2 groups as females with postmenopausal osteoporosis and healthy postmenopausal females (control group). A detailed anamnesis was taken from all subjects and then the ear, nose, and throat examinations were done followed by pure tone audiometry, tympanometry, and multifrequency tympanometry tests. The groups were compared in respect of pure tone average, bone conduction threshold, RF, static admittance, and tympanometric peak pressure values. Results: The mean age of the patients was 59.2 ± 4.53 years (range, 48-65 years) in the postmenopausal osteoporosis group and 57.11 ± 4.27 years (range, 48-65 years) in the control group ( P > .05). The mean resonance frequency values for the postmenopausal osteoporosis and control group were 954.41 ± 127.47 and 935.29 ± 126.39 Hz ( P > .05 ). The mean static admittance values for the postmenopausal osteoporosis and control group were 0.82 ± 0.33 and 0.85 ± 0.3 mmho, and mean tympanometric peak pressure values were −7.35 ± 18.52 and −6.94 ± 19.52 daPa ( P > .05 for both static admittance and tympanometric peak pressure). The mean pure tone averagevalues for the postmenopausal osteoporosis and control group were 20.96 ± 6.82 and 15.60 ± 7.81 dB, and mean bone conduction threshold values were 17.57 ± 6.03 and 12.10 ± 6.52 dB ( P < .05 for both pure tone average and bone conduction threshold). Conclusions: The results showed that the middle ear resonance frequency values were not affected in postmenopausal osteoporosis patients, but there was seen to be greater sensorineural hearing loss in females with postmenopausal osteoporosis compared to healthy postmenopausal females.

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Effects of Glycerol Test on Resonance Frequency in Patients with Ménière’s Disease

Cited by 3 publications

References 27 publications

Can Multifrequency Tympanometry Be Used in the Diagnosis of Meniere’s Disease? A Systematic Review and Meta-Analysis

Can Multifrequency Tympanometry Be Used in the Diagnosis of Meniere’s Disease? A Systematic Review and Meta-Analysis

The Diagnostic Value of Multifrequency Tympanometry in Patients with Ménière’s Disease: A Prospective Analysis

The Effect of Postmenopausal Osteoporosis on Middle Ear Resonance Frequency

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