Effects of Glycine on Serum Gonadotropins and Estradiol and on Concentrations of Free Amino Acids in the Middle Hypothalamus in Female Rats

Morishita, Hajime; Hashimoto, Tadashi; Kishi, Kazushi; Nakago, Kichijiro; Mikami, Hiroshi; Tomioka, Michio; Kuroiwa, Shigeki; Miyauchi, Yasuyo

doi:10.1159/000299602

Cited by 2 publications

(2 citation statements)

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“…12,53,54 In contrast to our findings above, Petzke et al 36 reported no significant differences in the δ 13 C and δ 15 N values of individual AAs from hair of a large cohort of German subjects. Regarding the significant effect of Gly in our work, Morishita et al 55 suggested that, in female rats, Gly is involved in the neural regulation of luteinizing hormone (LH) excretion. This hormone is directly related to male and female sex hormones, working in biochemical pathways that lead to the production and release of estrogen and testosterone.…”

Section: ■ Results and Discussionmentioning

confidence: 62%

“…Studies involving sex and stable isotopes are often related to dietary differences linked to social identity status in the organization of ancient societies. − The limited publications in this field suggest that sex differences do not interfere with the bulk isotope values. ,, In contrast to our findings above, Petzke et al reported no significant differences in the δ 13 C and δ 15 N values of individual AAs from hair of a large cohort of German subjects. Regarding the significant effect of Gly in our work, Morishita et al suggested that, in female rats, Gly is involved in the neural regulation of luteinizing hormone (LH) excretion. This hormone is directly related to male and female sex hormones, working in biochemical pathways that lead to the production and release of estrogen and testosterone.…”

Section: Resultsmentioning

confidence: 99%

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Compound-Specific Isotope Analysis of Human Hair: Predicting Behaviors and Biometrics beyond Dietary Factors

Matos

Jackson

2020

Anal. Chem.

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This study describes the use of amino acid quantitation and amino-acid-specific isotope ratio analysis of scalp hair of American individuals to predict soft biometric traits about the donors. The scalp hair of each donor was washed, dried, homogenized and acid hydrolyzed before analysis using liquid chromatography-isotope ratio mass spectrometry (LC-IRMS). A variety of statistical tests examined the relationships between the amino acid variables and biometric questionnaire responses, the latter of which could be assessed as continuous variablesin the case of age or body mass index (BMI)or as categorical variables in the case of sex and alcohol consumption. Correlations between biometric factors and amino acid δ 13C values were more significant after controlling for the extent of 13C in the subjects’ diets. Multivariate analysis revealed that the sex of a donor could be correctly predicted with cross-validated accuracies of 80% using the isotope ratios and 89% using amino acid quantities. Using amino acid δ 13C values or quantities, the age of a subject could only be predicted with an accuracy of ±27 years (95% CI). Hair treatments, such as chemical straitening and dying, did not have any measurable effect on the isotope ratios or quantities of amino acids in the hair. Unexpectedly, the δ 13C values of sulfur-containing amino acids were significantly different between teetotalers and subjects who consumed alcohol daily. Further refinement of this study, including larger cohorts with controlled behavioral states or genetic factors, could provide helpful investigative leads in forensic casework.

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