Effects of glycophorin and ganglioside GM3 on the blood circulation and tissue distribution of liposomes in rats

Yamauchi, Hitoshi; Kikuchi, Hiroshi; Yachi, Kiyoto; Sawada, Minoru; Tomikawa, Munehiro; Hirota, Shun

doi:10.1016/0378-5173(93)90297-s

Cited by 16 publications

(9 citation statements)

References 15 publications

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“…Nevertheless, other investigations showed that macromolecules bearing unshielded negative charges, namely, the ganglioside GM3, a sialic acid synthetic derivative, and a GM1 semisynthetic compound, increase the blood circulation time of sub-200 nm liposomes in mice [63]. Therefore, it can be concluded that the sterical organization of the ganglioside residues is primarily responsible for preventing the opsonisation of liposome containing glycolipids.…”

Section: The Opsonisation Processmentioning

confidence: 99%

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Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers

Salmaso

Caliceti

2013

Journal of Drug Delivery

280

177

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Over the last few decades, nanocarriers for drug delivery have emerged as powerful tools with unquestionable potential to improve the therapeutic efficacy of anticancer drugs. Many colloidal drug delivery systems are underdevelopment to ameliorate the site specificity of drug action and reduce the systemic side effects. By virtue of their small size they can be injected intravenously and disposed into the target tissues where they release the drug. Nanocarriers interact massively with the surrounding environment, namely, endothelium vessels as well as cells and blood proteins. Consequently, they are rapidly removed from the circulation mostly by the mononuclear phagocyte system. In order to endow nanosystems with long circulation properties, new technologies aimed at the surface modification of their physicochemical features have been developed. In particular, stealth nanocarriers can be obtained by polymeric coating. In this paper, the basic concept underlining the “stealth” properties of drug nanocarriers, the parameters influencing the polymer coating performance in terms of opsonins/macrophages interaction with the colloid surface, the most commonly used materials for the coating process and the outcomes of this peculiar procedure are thoroughly discussed.

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Section: The Opsonisation Processmentioning

confidence: 99%

“…Indeed, the GM1 decoration was effective in mice while it did not have any beneficial effect on the circulation time of liposomes in rats [63]. …”

Section: The Opsonisation Processmentioning

confidence: 99%

Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers

Salmaso

Caliceti

2013

Journal of Drug Delivery

280

177

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“…Liposomes can be cleared rapidly from sites of administration and are distributed within the cells of the reticuloendothelial system (RES) (Raz et al, 1981). Lipid composition, vesicle diameter, overall surface charge and incorporated material can be instrumental in the rate of uptake of liposomes by the RES and their circulation time in vivo (Allen et al, 1991;Gabizon & Papahadjopoulos, 1992;Yamauchi et al, 1993). Liposomallyencapsulated antigens are believed to exhibit enhanced antigen presentation and recruitment of macrophages in mammals, which may result in the potentiation of humoral responses and possibly generate T-cell mediated responses (Garcon & Six, 1991;Harding et al, 1991).…”

Section: Introductionmentioning

confidence: 98%

Serum anti-LPS antibody production by rainbow trout (Oncorhynchus mykiss) in response to the administration of free and liposomally-incorporated LPS fromAeromonas salmonicida

Nakhla¹,

Szalai²,

Banoub³

et al. 1997

Fish & Shellfish Immunology

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“…monosialoganglioside GM1 prolonged their circulation time in mice [71]. GM3 modification was also effective for prolonging the circulation of liposomes [72]. Ganglioside modifications afterwards were shown to be species-specific [73], although the development of long circulating liposomes opened a new field of liposomal applications in DDS besides those for delivery of drugs to RES and protection of materials from degradation in plasma.…”

Section: Long Circulating Liposomesmentioning

confidence: 97%

Evaluation of Drug Targeting Strategies and Liposomal Trafficking

Oku¹,

Tokudome²,

Asai³

et al. 2000

CPD

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Liposomes, that are biodegradable and essentially non-toxic, can encapsulate both hydrophilic and hydrophobic materials, and are utilized as drug carriers for drug delivery systems (DDS). Recent progress in gene technology provides a novel modality of therapy for various diseases with a variety of newlydeveloped cationic liposomes. Delivery of agents to the reticuloendothelial system (RES) is easily achieved since most conventional liposomes are trapped by the RES. For the purpose of delivery of agents to target organs other than RES, long-circulating liposomes have been developed by modifying the liposomal surface. Understanding of the in vivo dynamics of liposome-carried agents is required to evaluate the bioavailability of drugs encapsulated in liposomes. In this review, we focus on the in vivo trafficking of liposomes visualized by positron emission tomography (PET) and discuss the characteristics of liposomes that affect the targeting of drugs in vivo.

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Effects of glycophorin and ganglioside GM3 on the blood circulation and tissue distribution of liposomes in rats

Cited by 16 publications

References 15 publications

Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers

Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers

Serum anti-LPS antibody production by rainbow trout (Oncorhynchus mykiss) in response to the administration of free and liposomally-incorporated LPS fromAeromonas salmonicida

Evaluation of Drug Targeting Strategies and Liposomal Trafficking

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