Effects of Gold Nanoparticles on Angiogenesis in A Chick Chorioallantoic Membrane Model

Cirik, Samet; Elesad, Musa; Başar, Ebrar; E, Aksu; Erdem, Muaz; Yildiztekin, Faruk; Menekşe, Sinan; Çelikel, Rıdvan; Ipek, Mehmet Yusuf; Fermanli, Orhan; Eşrefoğlu, Mukaddes

doi:10.14235/bas.galenos.2020.3668

Cited by 4 publications

(2 citation statements)

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“…The most common use of the CAM in nanomaterials studies is in the observation and quantification of the effect on angiogenesis (Table ). The CAM, with regard to assessing the angiogenic or antiangiogenic properties of nanomaterials, has been applied to Au NPs, − peptide-conjugated Au NPs, − therapeutic conjugated Au NPs, Cu NPs, , TiO 2 NPs, ZnO NPs, − selenium NPs loaded in chitosan/collagen scaffolds, polycaprolactone scaffolds loaded with Y 2 O 3 NPs, therapeutic loaded mesoporous silica NPs (MSNPs), MSNPs in a collagen scaffold, magnetic metal-Fe 2 O 4 NPs, carbon Qdots, diamond NPs, , graphite NPs, ,, multiwall carbon nanotubes, , graphene nanosheets, fullerenes, , liposomes, , chronic myeloid leukemia cell exosomes, inulin/vitamin E micelles, PLGA NPs, ,, PLA NPs, polysaccharide NPs, , chitosan NPs, , dendrimers, − therapeutic nanoemulsions, − and vincristine-loaded hydroxyapatite NPs . Angiogenic studies in the CAM are done for two major reasons, the first being screening of an unexpected or unwanted effect and the second being the active use of the CAM to study therapeutic NPs with planned angiogenic effects.…”

Section: The Chick Embryo and Cam For Assessing Therapeutic Efficacy ...mentioning

confidence: 99%

Bridging the In Vitro to In Vivo gap: Using the Chick Embryo Model to Accelerate Nanoparticle Validation and Qualification for In Vivo studies

2022

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We postulate that nanoparticles (NPs) for use in therapeutic applications have largely not realized their clinical potential due to an overall inability to use in vitro results to predict NP performance in vivo. The avian embryo and associated chorioallantoic membrane (CAM) has emerged as an in vivo preclinical model that bridges the gap between in vitro and in vivo, enabling rapid screening of NP behavior under physiologically relevant conditions and providing a rapid, accessible, economical, and more ethical means of qualifying nanoparticles for in vivo use. The CAM is highly vascularized and mimics the diverging/converging vasculature of the liver, spleen, and lungs that serve as nanoparticle traps. Intravital imaging of fluorescently labeled NPs injected into the CAM vasculature enables immediate assessment and quantification of nano-bio interactions at the individual NP scale in any tissue of interest that is perfused with a microvasculature. In this review, we highlight how utilization of the avian embryo and its CAM as a preclinical model can be used to understand NP stability in blood and tissues, extravasation, biocompatibility, and NP distribution over time, thereby serving to identify a subset of NPs with the requisite stability and performance to introduce into rodent models and enabling the development of structure–property relationships and NP optimization without the sacrifice of large populations of mice or other rodents. We then review how the chicken embryo and CAM model systems have been used to accelerate the development of NP delivery and imaging agents by allowing direct visualization of targeted (active) and nontargeted (passive) NP binding, internalization, and cargo delivery to individual cells (of relevance for the treatment of leukemia and metastatic cancer) and cellular ensembles (e.g., cancer xenografts of interest for treatment or imaging of cancer tumors). We conclude by showcasing emerging techniques for the utilization of the CAM in future nano-bio studies.

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Section: The Chick Embryo and Cam For Assessing Therapeutic Efficacy ...mentioning

confidence: 99%

Bridging the In Vitro to In Vivo gap: Using the Chick Embryo Model to Accelerate Nanoparticle Validation and Qualification for In Vivo studies

2022

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“…[ 41 ] Nanomedicine is one of the effective methods to solve these problems. In recent decades, several nanoparticles were reported to emerge as angiogenesis‐promoting agents including reduced graphene oxide, [ 42 ] europium hydroxide nanoparticles, [ 43 ] gold nanoparticles (AuNPs), [ 44 ] etc. Similar to conventional angiogenic agents, these nanomaterials have also been found to promote angiogenesis by modulating the level of ROS.…”

Section: Introductionmentioning

confidence: 99%

3D Printing GelMA/PVA Interpenetrating Polymer Networks Scaffolds Mediated with CuO Nanoparticles for Angiogenesis

Liu

et al. 2022

Macromolecular Bioscience

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Biocompatible hydrogels have been considered one of the most well‐known and promising in various materials used in the fabrication of tissue‐engineering scaffolds. Although considerable progress has been made in recent decades, many limitations remain, such as poor mechanical and degradation properties of biomaterials. In addition, vascularization of tissue‐engineering scaffold is an enduring challenge, which limited the fabrication and application of scaffold with clinically relevant dimension. To cover these challenges, in this work, a novel nanocomposite interpenetrating polymer networks (IPN) hydrogel scaffold consists of methacrylated gelatin (GelMA), poly(vinyl alcohol) (PVA), and copper oxide nanoparticles (CuONPs) is fabricated by extrusion‐based 3D printing. A series of physiochemical and biological characterizations of the nanocomposite GelMA/PVA scaffolds are performed. Results showed that the mechanical and degradation properties of the nanocomposite GelMA/PVA scaffolds are obviously improved compared to GelMA scaffolds with single network. In vitro cell experiments and chick embryo angiogenesis (CEA) assay confirmed good cytocompatibility of the fabricated scaffold and its potential to promote cell migration and angiogenesis. In conclusion, altogether the results demonstrated that GelMA/PVA IPN scaffolds modified with CuONPs have great potential for fabrication of volumetric scaffolds and promote angiogenesis during tissue growth and repair.

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Biocompatible silver nanoparticles from apricot kernel skin: a green synthesis approach to antibacterial and antiangiogenic therapies

Nejati,

Torkay,

Girgin

et al. 2024

Chem. Pap.

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Effects of Gold Nanoparticles on Angiogenesis in A Chick Chorioallantoic Membrane Model

Cited by 4 publications

References 0 publications

Bridging the In Vitro to In Vivo gap: Using the Chick Embryo Model to Accelerate Nanoparticle Validation and Qualification for In Vivo studies

Bridging the In Vitro to In Vivo gap: Using the Chick Embryo Model to Accelerate Nanoparticle Validation and Qualification for In Vivo studies

3D Printing GelMA/PVA Interpenetrating Polymer Networks Scaffolds Mediated with CuO Nanoparticles for Angiogenesis

Biocompatible silver nanoparticles from apricot kernel skin: a green synthesis approach to antibacterial and antiangiogenic therapies

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