Effects of Gonadal Steroids on Melanocytes in Developing Hamsters

Diaz, Leslie; Gupta, Tapas K. Das; Beattie, Craig W.

doi:10.1111/j.1525-1470.1986.tb00522.x

Cited by 14 publications

(4 citation statements)

References 27 publications

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“…In contrast, a study of male Syrian hamsters demonstrated that estradiol produced a dose-related decrease in the number of scrotal skin melanocytes [125].…”

Section: Regulation Of Sex Hormonesmentioning

confidence: 87%

The melanogenesis and mechanisms of skin‐lightening agents – existing and new approaches

Gillbro¹,

Olsson²

2011

Intern J of Cosmetic Sci

317

251

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SynopsisSkin-lightening products are commercially available for cosmetic purposes to obtain lighter skin complexion. Clinically, they are also used for treatment of hyperpigmentary disorders such as melasma, café au lait spot and solar lentigo. All of these target naturally melanin production, and many of the commonly used agents are known as competitive inhibitors of tyrosinase, one of the key enzymes in melanogenesis. In this review, we present an overview of commonly used skin-whitening ingredients that are commercialized, but we also hypothesize on other mechanisms that could be important targets to control skin pigmentation such as for example regulation of the adrenergic and glutaminergic signalling and also control of tetrahydrobiopterins in the human skin. Ré suméLes produits éclaircissants sont disponibles dans le commerce pour des buts cosmétiques afin d'obtenir un tient plus clair. Ils sont égale-ment utilisés en clinique, pour le traitement de troubles hyper pigmentaires comme le melasma, les taches café au lait et le lentigo solaire. Tous ces produits ont pour cible la production naturelle de mélanine et beaucoup de ceux généralement utilisés sont reconnus comme des inhibiteurs compétitifs de la tyrosinase, une des enzymes clés de la mélanogénèse. Dans cette revue, nous présentons une vue d'ensemble des ingrédients généralement utilisés et commercialisés comme blanchissant cutanés mais nous formulons aussi l'hypothèse que d'autres mécanismes pourraient être des cibles importantes pour contrôler la pigmentation de la peau comme par exemple la régula-tion du signal adrénergique et glutaminergique ou le contrôle des tetrahydrobiopterines dans la peau humaine.

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“…In contrast, a study of male Syrian hamsters demonstrated that estradiol produced a dose-related decrease in the number of scrotal skin melanocytes [125].…”

Section: Regulation Of Sex Hormonesmentioning

confidence: 87%

The melanogenesis and mechanisms of skin‐lightening agents – existing and new approaches

Gillbro¹,

Olsson²

2011

Intern J of Cosmetic Sci

317

251

View full text Add to dashboard Cite

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“…The melanocytes in scrotal skin are controlled by androgens and are often distributed in a manner that allows qualitative measurements (136). A study of intact male Syrian hamsters demonstrated that estradiol produced a dose‐related decrease in the number of scrotal skin melanocytes (137). Furthermore, in the same study, the 5α‐DHT‐induced increase in pigmentation of the costovertebral spot hair follicles was reversed by estradiol.…”

Section: Pigmentationmentioning

confidence: 99%

The biological actions of estrogens on skin

Thornton

2002

Experimental Dermatology

223

157

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There is still extensive disparity in our understanding of how estrogens exert their actions, particularly in non-reproductive tissues such as the skin. Although it has been recognized for some time that estrogens have significant effects on many aspects of skin physiology and pathophysiology, studies on estrogen action in skin have been limited. However, estrogens clearly have an important function in many components of human skin including the epidermis, dermis, vasculature, hair follicle and the sebaceous, eccrine and apocrine glands, having significant roles in skin aging, pigmentation, hair growth, sebum production and skin cancer. The recent discovery of a second intracellular estrogen receptor (ERb) with different cell-specific roles to the classic estrogen receptor (ERa), and the identification of cell surface estrogen

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“…Moreover, melanin synthesis (Slominski et al, 2004) is regulated by a number of different hormones that could potentially be sensitive to environmental influences. Among these hormones, the positive effect exerted by testosterone (T) on the expression of melanin-based traits of vertebrates at both intraspecific (Stokkan, 1979;Diaz et al, 1986;González et al, 2001) and interspecific (Bókony et al, 2008) levels has been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Yolk testosterone shapes the expression of a melanin-based signal in great tits: an antioxidant-mediated mechanism?

Galván

Alonso‐Álvarez

2010

Journal of Experimental Biology

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SUMMARYConspicuous traits produced by melanin deposition in integuments are often involved in visual communication. The information content of melanin-based signals is unclear as their expression is tightly controlled by genes and, apparently, is less dependent on individual condition. In birds, high heritabilities have been attributed to melanin-based plumages, often on the basis of eggswapping manipulations (cross-fostering experiments). However, it is well known that female birds can differentially transfer testosterone to the egg yolk. Furthermore, high testosterone levels have been related to high oxidative stress. As we recently found that oxidative stress experienced during development influences the expression of melanin-based traits, here we manipulated the level of yolk testosterone in great tits (Parus major) to assess the influence of this maternal effect on the expression of the black breast stripe, a well-known melanin-based signal. We predicted that fledglings hatched from eggs with high testosterone levels will not only show larger black stripes but also experience changes in their antioxidant machinery. Indeed, the size of the black stripe of great tits hatched from testosterone-injected eggs was almost double that of controls. Furthermore, the same individuals showed a trend to higher levels of circulating antioxidants, which suggests an adaptive response against some testosterone-induced oxidative challenge.

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Effects of Gonadal Steroids on Melanocytes in Developing Hamsters

Cited by 14 publications

References 27 publications

The melanogenesis and mechanisms of skin‐lightening agents – existing and new approaches

The melanogenesis and mechanisms of skin‐lightening agents – existing and new approaches

The biological actions of estrogens on skin

Yolk testosterone shapes the expression of a melanin-based signal in great tits: an antioxidant-mediated mechanism?

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