Effects of gonadectomy and steroid treatment on renal prostaglandin 9-ketoreductase activity in the rat

Cagen, Lauren M.; Baer, Philip G.

doi:10.1016/0024-3205(87)90257-8

Cited by 14 publications

(7 citation statements)

References 23 publications

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“…Oxylipin profiling may also be relevant to further understanding sex differences in health and disease (17). Sex effects on fatty acid metabolism have been documented (18)(19)(20), but effects in oxylipins have largely been restricted to studies of one or two eicosanoids derived from AA (21,22) and to in vitro and ex vivo studies of sex hormone effects on oxylipin synthetic and degradative enzymes (23)(24)(25). Results from these studies appear to be conflicting, with no pattern being apparent.…”

mentioning

confidence: 99%

Dietary LA and sex effects on oxylipin profiles in rat kidney, liver, and serum differ from their effects on PUFAs

Leng

Winter

Aukema

2017

Journal of Lipid Research

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A vast literature on fatty acids in mammals exists, but comparable compositional data on oxylipins is lacking. Weanling Sprague-Dawley rats were therefore provided control diets or diets with higher linoleic acid (LA) or with higher LA and α-linolenic acid (LA+ALA) for 6 weeks. Kidneys, livers, and serum were analyzed for oxylipins and fatty acids. The proportion of tissue oxylipins derived from LA was greater than the relative proportion of LA itself, whereas arachidonic acid (AA) oxylipins were overrepresented in serum. Higher dietary LA increased kidney LA and AA oxylipins, despite not altering LA or AA. In liver, both LA and AA and their oxylipins were higher, whereas in serum only LA oxylipins were higher with higher dietary LA. Higher LA resulted in a higher ratio of n-6/n-3 PUFA-derived oxylipins; adding ALA to the LA diet mitigated this and many, but not all, effects of the LA diet. Approximately 40% of oxylipins detected were influenced by sex and, unlike their PUFA precursors, most (>90%) of these were higher in males. These differences in dietary LA and sex on oxylipin and fatty acid profiles further our understanding of the effects of fatty acids and may have implications for dietary LA recommendations.

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mentioning

confidence: 99%

Dietary LA and sex effects on oxylipin profiles in rat kidney, liver, and serum differ from their effects on PUFAs

Leng

Winter

Aukema

2017

Journal of Lipid Research

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“…in the kidney is PG El-9-ketoreductase. With regard to the contribution of PG E2-9-ketoreductase to control of intrarenal levels of PG E2 and Fzzr to date the available evidence is inconclusive (Cagen & Baer 1987). However, comparison of isotope ratios after incubation of rabbit renal medullary slices with a mixture of I4C-and 3H-labelled arachidonic acid indicated that PG Fzz was formed in this tissue by reduction of P G H2 and not by reduction of PG Ez (Qureshi & Cagen 1982).…”

Section: Discussionmentioning

confidence: 96%

Effect of tiopronin on prostaglandin synthesis in rabbit kidney medulla slices

Fujita

Fujimoto

Wada

et al. 1988

Journal of Pharmacy and Pharmacology

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The effect of 2-mercaptopropionylglycine (tiopronin), which is widely used for the treatment of various hepatic disorders, on the generation of medullary prostaglandins (PG) E2 and F2 alpha has been examined. Tiopronin had a potent inhibitory effect on PG E2 formation. Simultaneously, PG F2 alpha production was increased. In the presence of tiopronin the net increased amount of PG F2 alpha was much smaller than the net decreased amount of PG E2 (6-20%). These results suggest that tiopronin has the potential to modulate PG E2 and F2 alpha synthesis by affecting endoperoxide E2 isomerase or endoperoxide reductase and that this effect may represent some pharmacological action of the drug.

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“…These results suggest that oestradiol may preferentially stimu¬ late PGF production at the expense of PGE (PGF increases while PGE decreases), possibly by an activation of PGE-9-ketoreductase which converts PGE-2 to PGF-2a. In the rat, renal PGE-9-ketoreductase activity was enhanced with oestradiol treatment and progesterone antagonized this effect (Cagen & Baer, 1987). PGE-9-ketoreductase activity in the ovary has been reported (Watson et al, 1979) but the hormonal regulation and functional role of this enzyme in follicular development and ovulation have not been determined.…”

Section: Discussionmentioning

confidence: 97%

Exogenous progesterone reduces follicular prostaglandin E and 6-keto prostaglandin F-1 in the cyclic hamster

Brannian

Terranova²

1990

Reproduction

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In cyclic hamsters, exogenous progesterone (100 micrograms) administered s.c. at 09:00 h on the day of dioestrus II reduced prostaglandin (PG) E and 6-keto PGF-1 alpha but not PGF concentrations in preovulatory follicles measured at 09:00 h of pro-oestrus. The injection of 10 micrograms ovine LH (NIADDK-oLH-25) concurrently with 100 micrograms progesterone on dioestrus II prevented the decline in follicular PGE and 6-keto PGF-1 alpha values. Administration of LH alone did not significantly alter follicular PG concentrations. Inhibition of follicular PGE accumulation by progesterone was due to a decline in granulosa PGE concentration and not thecal PGE. Progesterone administration also reduced follicular oestradiol concentrations. Administration of oestradiol-17-cyclopentanepropionate (ECP) (10 micrograms) with progesterone did not prevent the decline in follicular PGE and 6-keto PGF-1 alpha but did increase follicular PGF concentrations. However, ECP given alone on dioestrus II reduced follicular PGE and increased PGF concentrations in preovulatory follicles on pro-oestrus. It is concluded that exogenous progesterone administered on dioestrus II inhibits granulosa PGE and 6-keto PGF-1 alpha accumulation in preovulatory follicles, probably by reducing serum LH concentrations, and that the granulosa cells, which are LH-dependent, are a major source of follicular PGE.

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Effects of gonadectomy and steroid treatment on renal prostaglandin 9-ketoreductase activity in the rat

Cited by 14 publications

References 23 publications

Dietary LA and sex effects on oxylipin profiles in rat kidney, liver, and serum differ from their effects on PUFAs

Dietary LA and sex effects on oxylipin profiles in rat kidney, liver, and serum differ from their effects on PUFAs

Effect of tiopronin on prostaglandin synthesis in rabbit kidney medulla slices

Exogenous progesterone reduces follicular prostaglandin E and 6-keto prostaglandin F-1 in the cyclic hamster

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