Effects of granulocyte colony-stimulating factor administration time on pain

Özkaraman, Ayşe; Argon, Gülümser; Yeşilbalkan, Öznur Usta; Dugum, O.; Yiğitaslan, Semra; Musmul, Ahmet; Alparslan, Güler Balcı

doi:10.4149/bll_2017_078

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Clinical and preclinical data support the role of rG-CSF for anti-nociception (Brack et al, 2004a; Chao et al, 2012; Ozkaraman et al, 2017). Administration of rG-CSF increases neutrophil count to treat chemotherapy- or radiation-induced neutropenia in patients (Zeidler et al, 2003).…”

Section: Discussionmentioning

confidence: 92%

Granulocyte-Colony Stimulating Factor-Induced Neutrophil Recruitment Provides Opioid-Mediated Endogenous Anti-nociception in Female Mice With Oral Squamous Cell Carcinoma

Scheff

Alemu

Klares

et al. 2019

Front. Mol. Neurosci.

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Oral cancer patients report severe function-induced pain; severity is greater in females. We hypothesize that a neutrophil-mediated endogenous analgesic mechanism is responsible for sex differences in nociception secondary to oral squamous cell carcinoma (SCC). Neutrophils isolated from the cancer-induced inflammatory microenvironment contain β-endorphin protein and are identified by the Ly6G+ immune marker. We previously demonstrated that male mice with carcinogen-induced oral SCC exhibit less nociceptive behavior and a higher concentration of neutrophils in the cancer microenvironment compared to female mice with oral SCC. Oral cancer cells secrete granulocyte colony stimulating factor (G-CSF), a growth factor that recruits neutrophils from bone marrow to the cancer microenvironment. We found that recombinant G-CSF (rG-CSF, 5 μg/mouse, intraperitoneal) significantly increased circulating Ly6G+ neutrophils in the blood of male and female mice within 24 h of administration. In an oral cancer supernatant mouse model, rG-CSF treatment increased cancer-recruited Ly6G+ neutrophil infiltration and abolished orofacial nociceptive behavior evoked in response to oral cancer supernatant in both male and female mice. Local naloxone treatment restored the cancer mediator-induced nociceptive behavior. We infer that rG-CSF-induced Ly6G+ neutrophils drive an endogenous analgesic mechanism. We then evaluated the efficacy of chronic rG-CSF administration to attenuate oral cancer-induced nociception using a tongue xenograft cancer model with the HSC-3 human oral cancer cell line. Saline-treated male mice with HSC-3 tumors exhibited less oral cancer-induced nociceptive behavior and had more β-endorphin protein in the cancer microenvironment than saline-treated female mice with HSC-3 tumors. Chronic rG-CSF treatment (2.5 μg/mouse, every 72 h) increased the HSC-3 recruited Ly6G+ neutrophils, increased β-endorphin protein content in the tongue and attenuated nociceptive behavior in female mice with HSC-3 tumors. From these data, we conclude that neutrophil-mediated endogenous opioids warrant further investigation as a potential strategy for oral cancer pain treatment.

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Section: Discussionmentioning

confidence: 92%

Granulocyte-Colony Stimulating Factor-Induced Neutrophil Recruitment Provides Opioid-Mediated Endogenous Anti-nociception in Female Mice With Oral Squamous Cell Carcinoma

Scheff

Alemu

Klares

et al. 2019

Front. Mol. Neurosci.

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Oral loratadine in the management of G-CSF-induced bone pain: a pilot study

et al. 2019

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This pilot study aimed to ascertain if bone pain induced by Granulocyte-Colony Stimulating Factors (G-CSFs) can be alleviated or eliminated by administration of the oral antihistamine loratadine (Clarityn ®). Twelve cancer patients receiving chemotherapy were included in the study. Daily pain increased initially from precycle one to post cycle one in all patients. All twelve patients were commenced on loratadine on cycle 2, with three participants also taking PRN pain medication in addition to this, including PRN Ibrufen (n=1) or tramadol (n=2). Pain decreased towards the later cycles following commencement of loratadine in cycle 2, with the exception of one patient who also took PRN tramadol in cycle 3. Oral loratadine was found to be associated with pain reduction in cancer patients receiving G-CSFs.

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Effects of granulocyte colony-stimulating factor administration time on pain

Abstract: The results of the present study have demonstrated that the pain score related to G-CSF administration at 14:00 p.m. was significantly reduced. Thus, in order to minimize the pain, it will be more beneficial to administer G-CSF at 14: 00 (Tab. 4, Ref. 31). Text in PDF www.elis.sk.

Cited by 2 publications

References 23 publications

Granulocyte-Colony Stimulating Factor-Induced Neutrophil Recruitment Provides Opioid-Mediated Endogenous Anti-nociception in Female Mice With Oral Squamous Cell Carcinoma

Granulocyte-Colony Stimulating Factor-Induced Neutrophil Recruitment Provides Opioid-Mediated Endogenous Anti-nociception in Female Mice With Oral Squamous Cell Carcinoma

Oral loratadine in the management of G-CSF-induced bone pain: a pilot study

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