Effects of Grape Pomace Polyphenols and In Vitro Gastrointestinal Digestion on Antimicrobial Activity: Recovery of Bioactive Compounds

Caponio, Giusy Rita; Noviello, Mirella; Calabrese, Francesco Maria; Gambacorta, Giuseppe; Giannelli, Gianluigi; Angelis, Maria De

doi:10.3390/antiox11030567

Cited by 52 publications

(34 citation statements)

References 70 publications

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“…Previous results showed the capacity of bacteria to grow in the presence of polyphenols as they metabolize them. A positive correlation between bacteria effects and the modification of pH during gastrointestinal digestion was observed; in fact, in the presence of digested grape pomace extracts, Gram-positive (Bacillus megaterium and Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria were inhibited, while a probiotic Lactobacillus plantarum grew, as shown in Caponio et al [ 107 ]. In line with these results, our group is performing a study on the anticancerogenic effects of digested grape pomace extracts in human colon cancer cell lines.…”

Section: Fruit Componentsmentioning

confidence: 69%

“…Grape pomace is a major by-product obtained from the winemaking process that contain phenolic compounds with beneficial effects on human health. Recently, we evaluated the antioxidant effects of grape pomace digested extracts [ 107 ], evaluating in vitro models their prebiotics and probiotic activities. Previous results showed the capacity of bacteria to grow in the presence of polyphenols as they metabolize them.…”

Section: Fruit Componentsmentioning

confidence: 99%

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Nutraceuticals: Focus on Anti-Inflammatory, Anti-Cancer, Antioxidant Properties in Gastrointestinal Tract

et al. 2022

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In recent years, nutraceuticals have gained great popularity, owing to their physiological and potential health effects, such as anti-inflammatory, anti-cancer, antioxidant, and prebiotic effects, and their regulation of lipid metabolism. Since the Mediterranean diet is a nutritionally recommended dietary pattern including high-level consumption of nutraceuticals, this review aimed to summarize the main results obtained by our in vitro and in vivo studies on the effects of the major constituents of the Mediterranean diet (i.e., extra virgin olive oil compounds, polyunsaturated fatty acids, and fruit components). Based on experimental studies, the therapeutic purpose of nutraceuticals depends on their bioavailability, solubility, toxicity, and delivery system. This review provides more in-depth knowledge on the effects linked to nutraceuticals administration on human health, focusing the gastrointestinal tract and suggesting specific dietary components for personalized adjuvant therapies.

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Section: Fruit Componentsmentioning

confidence: 69%

Section: Fruit Componentsmentioning

confidence: 99%

Nutraceuticals: Focus on Anti-Inflammatory, Anti-Cancer, Antioxidant Properties in Gastrointestinal Tract

et al. 2022

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“…Several studies have demonstrated that the in vitro gastrointestinal digestion increased the bioaccessibility of polyphenols [ 23 , 25 ]. Thus, in this study we determined the antioxidant activity, the total phenolic content (TPC), and the polyphenolic composition of the GP gastrointestinal digested extract.…”

Section: Resultsmentioning

confidence: 99%

“…One of these is represented by the concept of bioavailability of polyphenols, which in turn depends on the relative content of compounds released from the food matrix along the digestive system (bioaccessibility), the digestive stability, and the efficiency of the transepithelial passage (intestinal absorption) [ 20 , 21 , 22 ]. As previously published, the in vitro simulated gastrointestinal digestion of GP extracts improved the bioavailability and bioaccessibility of polyphenols with a consequent increase in both antioxidant activity and phenolic compound content [ 23 ]. A useful option to evaluate the bioactivity effects of these extracts consists in using cell lines that reproduce in vitro the mechanisms of action in vivo.…”

Section: Introductionmentioning

confidence: 96%

Anti-Proliferative and Pro-Apoptotic Effects of Digested Aglianico Grape Pomace Extract in Human Colorectal Cancer Cells

et al. 2022

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Grape pomace (GP)—the major by-product of winemaking processes—still contains bioactive molecules with known beneficial properties for human health, such as an antiradical scavenging activity or an antiproliferative activity of tumors. In vitro studies have demonstrated that GP polyphenols specifically influence colon cancer cell proliferation. In addition to previously published work, we tested the phenolic compounds of Aglianico GP following an in vitro simulated gastrointestinal digestion on colorectal cancer cell lines at different degrees of differentiation. Our experiments, using HT29 and SW480 cells, confirmed the anti-proliferative effect of GP gastrointestinal digested extract and provided intriguing insights on the way it influences the cancer cell features (i.e., viability, proliferation, and apoptosis). We observed that Aglianico GP extract showed a great ability to affect cell proliferation and apoptosis. Interestingly, both HT29 and SW480 cells produced a significant increase in Bax, and a significant increase in the Bax/Bcl-2 ratio and caspase-3. The gastrointestinal digested GP extract was previously characterized both for antioxidant activity and phenolic composition. As a result, the TPC and the antioxidant activity reached high values in the Aglianico GP digested extract, and the main compounds assessed by UHPLC-DAD were anthocyanins, phenolic acids, and flavonoids. This work shed light on the use of digested GP extract as a dietary ingredient, a very sustainable source of nutritional compounds with potential health benefits for colon cancer cell proliferation.

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“…Similarly, no health effects were considered, but other in vivo experiments report favorable health effects when administering a grape pomace extract to hypertensive rats, according to its high content of phenolics in general and anthocyanins in particular [ 102 ]. These compounds can also exert antimicrobial effects against some species ( Escherichia coli , Bacillus megaterium, and Listeria monocytogenes ) [ 103 ], potentially exerting other health effects on the consumers, but further experiments are required to demonstrate them conclusively.…”

Section: Selected Foods Enriched With Agro-industrial Fruit Byproduct...mentioning

confidence: 99%

Agro-Industrial Fruit Byproducts as Health-Promoting Ingredients Used to Supplement Baked Food Products

Zuñiga-Martínez

Domínguez-Ávila

Robles-Sánchez

et al. 2022

Foods

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One of the biggest problems faced by food industries is the generation of large amounts of agro-industrial byproducts, such as those derived from fruit processing, as well as the negative effects of their inadequate management. Approximately 1/3 of the food produced worldwide is unused or is otherwise wasted along the chain, which represents a burden on the environment and an inefficiency of the system. Thus, there is growing interest in reintroducing agro-industrial byproducts (both from fruits and other sources) into the processing chain, either by adding them as such or utilizing them as sources of health-promoting bioactive compounds. The present work discusses recent scientific studies on the nutritional and bioactive composition of some agro-industrial byproducts derived from fruit processing, their applications as ingredients to supplement baked foods, and their main biological activities on the consumer’s health. Research shows that agro-industrial fruit byproducts can be incorporated into various baked foods, increasing their fiber content, bioactive profile, and antioxidant capacity, in addition to other positive effects such as reducing their glycemic impact and inducing satiety, all while maintaining good sensory acceptance. Using agro-industrial fruit byproducts as food ingredients avoids discarding them; it can promote some bioactivities and maintain or even improve sensory acceptance. This contributes to incorporating edible material back into the processing chain as part of a circular bioeconomy, which can significantly benefit primary producers, processing industries (particularly smaller ones), and the final consumer.

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Effects of Grape Pomace Polyphenols and In Vitro Gastrointestinal Digestion on Antimicrobial Activity: Recovery of Bioactive Compounds

Cited by 52 publications

References 70 publications

Nutraceuticals: Focus on Anti-Inflammatory, Anti-Cancer, Antioxidant Properties in Gastrointestinal Tract

Nutraceuticals: Focus on Anti-Inflammatory, Anti-Cancer, Antioxidant Properties in Gastrointestinal Tract

Anti-Proliferative and Pro-Apoptotic Effects of Digested Aglianico Grape Pomace Extract in Human Colorectal Cancer Cells

Agro-Industrial Fruit Byproducts as Health-Promoting Ingredients Used to Supplement Baked Food Products

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