Effects of grazing endophyte-infected tall fescue on eCG and progestogen concentrations from gestation days 21 to 300 in the mare

Brendemuehl, J.P.; Carson, Robert L.; Wenzel, J. G. W.; Boosinger, T. R.; Shelby, Richard A.

doi:10.1016/0093-691x(96)00144-6

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…However, other studies have found no increased equine pregnancy loss up to day 300, despite lower progestagen concentrations between gestational days 90 and 120 (Brendemuehl et al, 1996). In general, equine pregnancy rates are usually fairly good on E fescue pasture, as long as mares have progressed through the transitional phase in the early spring and are already cycling normally and they are not currently being exposed to ergotized grains or grasses (Evans et al, 2004b).…”

Section: Subfertilitymentioning

confidence: 94%

Fescue toxicosis

Evans¹,

Blodgett²,

Rottinghaus³

2012

Veterinary Toxicology

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Section: Subfertilitymentioning

confidence: 94%

Fescue toxicosis

Evans¹,

Blodgett²,

Rottinghaus³

2012

Veterinary Toxicology

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“…Studies in the mare have demonstrated (Marek and Roth 1980; Porter and Thompson 1992; Cross et al. 1995; Brendemuehl et al. 1996; Fiserova et al.…”

Section: Introductionmentioning

confidence: 98%

“…Studies in the mare have demonstrated (Marek and Roth 1980;Porter and Thompson 1992;Cross et al 1995;Brendemuehl et al 1996;Fiserova et al 1997;Blodgett 2001;Ryan et al 2001;Copetti et al 2002;Evans 2002;Youngblood et al 2004;Lehner et al 2008) that consuming toxic endophyte-infected grasses during the last 3 months of gestation leads to a high incidence of foal loss and other associated medical problems. The clinical symptoms include spontaneous abortions, thickened placenta and agalactia.…”

Section: Introductionmentioning

confidence: 99%

Effect of Feeding Fescue Seed Containing Ergot Alkaloid Toxins on Stallion Spermatogenesis and Sperm Cells

Fayrer-Hosken¹,

Stanley

Hill³

et al. 2012

Reprod Domestic Animals

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Contents The cellular effects of tall fescue grass–associated toxic ergot alkaloids on stallion sperm and colt testicular tissue were evaluated. This was a continuation of an initial experiment where the effects of toxic ergot alkaloids on the stallion spermiogram were investigated. The only spermiogram parameter in exposed stallions that was affected by the toxic ergot alkaloids was a decreased gel-free volume of the ejaculate. This study examined the effect of toxic ergot alkaloids on chilling and freezing of the stallion sperm cells. The effect of toxic ergot alkaloids on chilled extended sperm cells for 48 h at 5 °C was to make the sperm cells less likely to undergo a calcium ionophore–induced acrosome reaction. The toxic ergot alkaloids had no effect on the freezability of sperm cells. However, if yearling colts were fed toxic ergot alkaloids, then the cytological analysis of meiotic chromosome synapsis revealed a significant increase in the proportion of pachytene spermatocytes showing unpaired sex chromosomes compared to control spermatocytes. There was little effect of ergot alkaloids on adult stallions, but there might be a significant effect on yearling colts.

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“…In the equine species, the main symptoms are: excessive sweating, lameness, and many reproductive disorders (prolonged gestation, abortion, dystocia, retained and thickened placenta, abnormal foal maturation, agalactia and foal deaths) [1,5,6,16]. Also, reduced serum prolactin and progesterone levels occurred in mares consuming endophyte-infected grasses [2,15]. The mechanisms which cause the reproductive problems in the mare have still not been completely clarified.…”

Section: Introductionmentioning

confidence: 99%

Toxicokinetics of ergovaline in the horse after an intravenous administration

et al. 2001

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-The toxicokinetics of ergovaline (an ergopeptine mycotoxin present in some grasses infected with endophytic fungus of the genus Neotyphodium) were studied after intravenous administration of a single dose of 15 µg/kg bwt in four gelding horses. Plasma ergovaline concentrations were measured by high performance liquid chromatography, and the kinetic data were described by a three-compartment model. The elimination half-life and the total clearance of ergovaline were found to be 56.83 ± 13.48 min and 0.020 ± 0.004 L/min⋅kg, respectively. According to the toxicological data previously reported in the horse, and in spite of the very low dose administered, clinical signs were observed, including excessive coolness of the ears and the nose, excessive sweating and prostration. ergovaline / mycotoxin / horse / kinetics / NeotyphodiumRésumé -Étude toxicocinétique de l'ergovaline chez le cheval après injection intraveineuse. Les paramètres toxicocinétiques de l'ergovaline (un alcaloïde ergopeptidique présent dans les graminées porteuses d'un champignon endophyte du genre Neotyphodium) ont été déterminés après l'injection intraveineuse d'une dose de 15 µg/kg chez quatre chevaux hongres. Les concentrations plasmatiques d'ergovaline ont été mesurées par chromatographie liquide haute performance et les données cinétiques décrites selon un modèle à trois compartiments. La demi-vie d'élimination et la clairance totale de l'ergovaline ont été respectivement de 56,83 ± 13,48 min et de 0,020 ± 0,004 L/min⋅kg. Malgré la très faible dose administrée, des signes cliniques compatibles avec les données toxicologiques rapportées dans l'espèce équine ont été observés, à savoir hypothermie des oreilles et du nez, hypersudation et prostration.ergovaline / mycotoxine / cinétique / cheval / Neotyphodium Vet. Res. 32 (2001) 509-513 509

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Effects of grazing endophyte-infected tall fescue on eCG and progestogen concentrations from gestation days 21 to 300 in the mare

Cited by 11 publications

References 18 publications

Fescue toxicosis

Fescue toxicosis

Effect of Feeding Fescue Seed Containing Ergot Alkaloid Toxins on Stallion Spermatogenesis and Sperm Cells

Toxicokinetics of ergovaline in the horse after an intravenous administration

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