Effects of gross total resection and subtotal resection on survival outcomes of glioma patients: a meta-analysis

Shi, Yu; Liu, Chengming; Cheng, Dejing; Tang, Liyan; Qi, Zhenyu

doi:10.1080/02648725.2023.2177034

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…While gross total resection has been shown to prolong overall survival compared to subtotal resection in patients with parenchymal gliomas, the impact of the extent of resection on overall survival in IVGBM is unclear due to the modest number of reported cases [32]. In the present series, gross total resection was achieved in two patients.…”

Section: Discussionmentioning

confidence: 67%

Management and Molecular Characterization of Intraventricular Glioblastoma: A Single-Institution Case Series

Parker,

Kalluri,

Materi

et al. 2023

IJMS

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While the central nervous system (CNS) tumor classification has increasingly incorporated molecular parameters, there is a paucity of literature reporting molecular alterations found in intraventricular glioblastoma (IVGBM), which are rare. We present a case series of nine IVGBMs, including molecular alterations found in standardized next-generation sequencing (NGS). We queried the clinical charts, operative notes, pathology reports, and radiographic images of nine patients with histologically confirmed IVGBM treated at our institution (1995–2021). Routine NGS was performed on resected tumor tissue of two patients. In this retrospective case series of nine patients (22% female, median (range) age: 64.3 (36–85) years), the most common tumor locations were the atrium of the right lateral ventricle (33%) and the septum pellucidum (33%). Five patients had preoperative hydrocephalus, which was managed with intraoperative external ventricular drains in three patients and ventriculoperitoneal shunts in one patient. Hydrocephalus was managed with subtotal resection of a fourth ventricular IVGBM in one patient. The most common surgical approach was transcortical intraventricular (56%). Gross total resection was achieved in two patients, subtotal resection was achieved in six patients, and one patient received a biopsy only. Immunohistochemistry for IDH1 R132H mutant protein was performed in four cases and was negative in all four. Genetic alterations common in glioblastoma, IDH-wildtype, were seen in two cases with available NGS data, including EGFR gene amplification, TERT promoter mutation, PTEN mutation, trisomy of chromosome 7, and monosomy of chromosome 10. Following surgical resection, four patients received adjuvant chemoradiation. Median survival among our cohort was 4.7 months (IQR: 0.9–5.8 months). Management of IVGBM is particularly challenging due to their anatomical location, presentation with obstructive hydrocephalus, and fast growth, necessitating prompt intervention. Additional studies are needed to better understand the genetic landscape of IVGBM compared to parenchymal glioblastoma and may further elucidate the unique pathophysiology of these rare tumors.

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Section: Discussionmentioning

confidence: 67%

Management and Molecular Characterization of Intraventricular Glioblastoma: A Single-Institution Case Series

Parker,

Kalluri,

Materi

et al. 2023

IJMS

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Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery: lessons from a case series

Boccuni,

Roca-Ventura,

Buloz-Osorio

et al. 2024

J Neurooncol

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Purpose The objective of this prospective, single-centre case series was to investigate feasibility, clinical outcomes, and neural correlates of non-invasive Neuromodulation-Induced Cortical Prehabilitation (NICP) before brain tumor surgery. Previous studies have shown that gross total resection is paramount to increase life expectancy but is counterbalanced by the need of preserving critical functional areas. NICP aims at expanding functional margins for extensive tumor resection without functional sequelae. Invasive NICP (intracranial neuromodulation) was effective but characterized by elevated costs and high rate of adverse events. Non-invasive NICP (transcranial neuromodulation) may represent a more feasible alternative. Nonetheless, up to this point, non-invasive NICP has been examined in only two case reports, yielding inconclusive findings. Methods Treatment sessions consisted of non-invasive neuromodulation, to transiently deactivate critical areas adjacent to the lesion, coupled with intensive functional training, to activate alternative nodes within the same functional network. Patients were evaluated pre-NICP, post-NICP, and at follow-up post-surgery. Results Ten patients performed the intervention. Feasibility criteria were met (retention, adherence, safety, and patient’s satisfaction). Clinical outcomes showed overall stability and improvements in motor and executive function from pre- to post-NICP, and at follow-up. Relevant plasticity changes (increase in the distance between tumor and critical area) were observed when the neuromodulation target was guided by functional neuroimaging data. Conclusion This is the first case series demonstrating feasibility of non-invasive NICP. Neural correlates indicate that neuroimaging-guided target selection may represent a valid strategy to leverage neuroplastic changes before neurosurgery. Further investigations are needed to confirm such preliminary findings.

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Effects of gross total resection and subtotal resection on survival outcomes of glioma patients: a meta-analysis

Cited by 2 publications

References 40 publications

Management and Molecular Characterization of Intraventricular Glioblastoma: A Single-Institution Case Series

Management and Molecular Characterization of Intraventricular Glioblastoma: A Single-Institution Case Series

Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery: lessons from a case series

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