The severity of cassava bacterial blight at two sites in the forest-savanna transition (FST) and dry savanna (DS) zones of West Africa were studied by assessing the effects of: (i) shift of planting date; (ii) potassium fertilizer application and mulching; (iii) intercropping cassava with sorghum or cowpea vs. cassava monoculture; and (iv) the combination of these measures. Disease severity of bacterial blight in two genotypes was generally reduced by 20 -60% by late planting, without a negative effect on cassava root yield, in monocropping systems in most treatments in the FST zone (reduction in four treatments, and increase in two treatments, out of 19) and the DS zone (two of eight treatments in 1 year). Late planting led to crop failure in the DS zone in the second year. Intercropping cassava with sorghum reduced bacterial blight severity significantly, up to 80% at normal (all treatments) and late planting time (three out of six treatments) in the FST zone, and in some treatments (four out of seven) at normal planting in the DS zone. Intercropping of cassava with cowpea in the DS zone also reduced disease severity. Cassava-sorghum intercropping generally had no effect on root yield compared with cassava monocropping at both planting times in the FST zone and provided an additional harvest of the intercrop, while yield was affected by intercropping in the DS zone at late, and in some treatments (three out of seven) at normal, planting time. Mulching and potassium treatment had no effect on disease severity, but increased or decreased root yield in some treatments in both sites. Analysis of combined data showed that cropping system, year, site, and site combined with planting date were the highest significant determinants of variation in bacterial blight development.