Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells

Tanaka, Toshiaki; Yamagata, Yuriko; Takasaki, Akihisa; Matsuoka, Aki; Tamura, Hiroshi; Sugino, Norihiro

doi:10.1016/j.fertnstert.2007.07.1304

Cited by 18 publications

(12 citation statements)

References 49 publications

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“…Patients underwent in vitro fertilization and embryo transfer (IVF‐ET) with a standardized ovarian‐stimulation protocol as reported previously [31] consisting of GnRH agonist (900 mg/day buserelin acetate, Suprecur; Mochida Pharmaceutical Co. Ltd., Tokyo, Japan) beginning in the mid‐luteal phase, followed by 300 IU follicle stimulating hormone (FSH, Fertinorm P; Serono‐Japan Co. Ltd., Chiba, Japan) on the second and third day, 225 IU FSH on day 4 and 5, and thereafter by 150 IU human menopausal gonadotropins (hMG, HMG‐teizo; Asuka Co. Ltd., Tokyo, Japan). When at least three follicles reached 18 mm or more in diameter by ultrasonography 10,000 IU human chorionic gonadotropin (Gonatropin; Asuka Pharmaceutical Co., Ltd., Tokyo, Japan) was administered and an ultrasound‐guided trans‐vaginal oocyte retrieval was performed 34 hr later.…”

Section: Methodsmentioning

confidence: 99%

Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

Tamura

Takasaki

Miwa

et al. 2007

Journal of Pineal Research

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580

483

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We investigated the relationship between oxidative stress and poor oocyte quality and whether the antioxidant melatonin improves oocyte quality. Follicular fluid was sampled at oocyte retrieval during in vitro fertilization and embryo transfer (IVF-ET). Intrafollicular concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in women with high rates of degenerate oocytes were significantly higher than those with low rates of degenerate oocytes. As there was a negative correlation between intrafollicular concentrations of 8-OHdG and melatonin, 18 patients undergoing IVF-ET were given melatonin (3 mg/day), vitamin E (600 mg/day) or both melatonin and vitamin E. Intrafollicular concentrations of 8-OHdG and hexanoyl-lysine adduct were significantly reduced by these antioxidant treatments. One hundred and fifteen patients who failed to become pregnant with a low fertilization rate (< or =50%) in the previous IVF-ET cycle were divided into two groups during the next IVF-ET procedure; 56 patients with melatonin treatment (3 mg/day) and 59 patients without melatonin treatment. The fertilization rate was improved by melatonin treatment compared to the previous IVF-ET cycle. However, the fertilization rate was not significantly changed without melatonin treatment. Oocytes recovered from preovulatory follicles in mice were incubated with H2O2 for 12 hr. The percentage of mature oocytes with a first polar body was significantly reduced by addition of H2O2 (300 microm). The inhibitory effect of H2O2 was significantly blocked by simultaneous addition of melatonin. In conclusion, oxidative stress causes toxic effects on oocyte maturation and melatonin protects oocytes from oxidative stress. Melatonin is likely to improve oocyte quality and fertilization rates.

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Section: Methodsmentioning

confidence: 99%

Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

Tamura

Takasaki

Miwa

et al. 2007

Journal of Pineal Research

Self Cite

580

483

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“…Ovarian stimulation was performed with the long protocol with a GnRH agonist as reported elsewhere (22). The sildenafil suppositories were prepared from the oral tablets.…”

Section: Sildenafil Citrate (Viagra) Treatmentmentioning

confidence: 99%

Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium

Takasaki

Tamura

Miwa

et al. 2010

Fertility and Sterility

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148

112

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“…The GH receptor is present in the cumulus cells and oocytes of several species, including human beings [4]. The activity of GH might also influence luteal function, either directly or indirectly, via insulin-like growth factor-1 (IGF-1) [8]. The activity of GH might also influence luteal function, either directly or indirectly, via insulin-like growth factor-1 (IGF-1) [8].…”

Section: Introductionmentioning

confidence: 99%

“…The addition of GH during ovulation induction could optimize the clinical pregnancy rate of IVF and embryo transfer by increasing the number of oocytes retrieved and improving the quality of both eggs and embryos [5][6][7]. The activity of GH might also influence luteal function, either directly or indirectly, via insulin-like growth factor-1 (IGF-1) [8]. By contrast, its effects on endometrial receptivity and implantation remain inconclusive.…”

Section: Introductionmentioning

confidence: 99%

The effects of growth hormone on clinical outcomes after frozen–thawed embryo transfer

Wang¹,

Jiang²,

Zhang³

et al. 2016

Intl J Gynecology & Obste

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Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells

Cited by 18 publications

References 49 publications

Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium

The effects of growth hormone on clinical outcomes after frozen–thawed embryo transfer

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