Effects of Growth Hormone and Nutritional Status on Cardiac Glycogen in the Rat1

Adrouny, George A.; Russell, Jane A.

doi:10.1210/endo-59-2-241

Cited by 30 publications

(9 citation statements)

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“…It was clearly shown that there was a positive correlation between cardiac glycogen content and serum free fatty acids level. This results confirms the effects of fasting, feeding and feeding patterns for cardiac glycogen content that have been previously reported by others (1,8). However, present results extend the previous observation to a certain degree by showing a good correlation of food intake, serum-free fatty acids level and cardiac glycogen content by meal feeding schedule.…”

supporting

confidence: 93%

Effects of diet on cyclic change of cardiac glycogen content in meal-fed rats.

Matsumoto

Funabiki

1977

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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supporting

confidence: 93%

Effects of diet on cyclic change of cardiac glycogen content in meal-fed rats.

Matsumoto

Funabiki

1977

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…In contrast to this the glycogen content of adult lung tissue (table I) and cardiac ven tricular muscle [Adrouny and Russell, 1956;Adrouny, 1969] increased during fasting. The reason for this increase in glycogen con tent is not yet fully elucidated.…”

Section: Discussionmentioning

confidence: 67%

Lung Glycogen Metabolism in Suckling Rats: A Comparative Study

1988

Neonatology

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Glycogen metabolism was studied in lungs of suckling rats and the data was compared with that of the adult. From the data it appeared that the control of glycogen metabolism of lung tissue of suckling rats differs from that of adult lung. After a 24-hour fasting period, the lung glycogen content of 1- to 2-week-old rats was decreased (p < 0.05). This was accompanied by an increased (10%) phosphorylase activity (p < 0.001). In contrast to this, the lung glycogen content of adult lung increased by about 26% (p < 0.05) while at the same time the hexokinase activity increased by about 39% and the phosphorylase activity decreased by about 65%. Also, the 1- to 2-week-old lung utilized glycogen more readily (9.00 ± 0.04 μmol/g/h) than adult lung (3.70 ± 0.15 μmol/g/h). This means that lung tissue of suckling rats is more dependent on glycogen than adult lung which is probably the reason for the difference in control.

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“…The enzymes involved in the regulation of the rate of glycogen synthesis and breakdown are controlled by various hormones and intracellular metabolic intermediates (52)(53)(54)(55).…”

Section: Discussionmentioning

confidence: 99%

“…In the fasting state with high circulating FFA concentrations, myocardial glycogen stores increase (55). Animal studies have also shown that with exercise or ischemia the myocardial glycogen content falls significantly (56)(57)(58)(59).…”

Section: Discussionmentioning

confidence: 99%

Effects of acute hyperglycemia on myocardial glycolytic activity in humans.

Wisneski¹,

Stanley²,

Neese³

et al. 1990

J. Clin. Invest.

100

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The effects of hyperglycemia on myocardial glucose metabolism were investigated in seven healthy male subjects (age 24±4 yr). I6-C4qGlucose and IU-'3Cilactate were infused as tracers. Circulating glucose was elevated to two hyperglycemic levels using a clamp technique for 1 h at each level. The mean arterial glucose concentration was 4.95±0.29 (control), 8.33±0.31 and 10.84±0.60 jumol/ml, respectively. Glucose extraction increased significantly from control (0.15±0.13 gsmol/ ml) during each level of the glucose clamp (0.28±0.12, P < 0.02, and 0.54±0.14 ;tmol/ml, P < 0.005, respectively). Myocardial production of '4CO2 showed that during control 9±10% of exogenous glucose was oxidized immediately upon extraction. Despite a significant increase in the amount of exogenous glucose oxidized with level II hyperglycemia, it represented only 32±10% of the glucose extracted.[I3C]Lactate analysis showed that the myocardium was releasing lactate; during control 40±30% of this lactate was derived from exogenous glucose and during hyperglycemia this value increased to 97±37% (P < 0.005). Thus, these data show that during short-term hyperglycemia, myocardial glucose extraction is enhanced. However, despite increases in exogenous glucose oxidation and the contribution of exogenous glucose to lactate release, the majority of the extracted glucose (i.e., 57%) is probably stored as glycogen. (J. Clin. Invest. 1990Invest. . 85:1648Invest. -1656.) myocardial metabolism * glucose oxidation * lactate release * glycogen * free fatty acids

show abstract

Effects of Growth Hormone and Nutritional Status on Cardiac Glycogen in the Rat1

Cited by 30 publications

References 0 publications

Effects of diet on cyclic change of cardiac glycogen content in meal-fed rats.

Effects of diet on cyclic change of cardiac glycogen content in meal-fed rats.

Lung Glycogen Metabolism in Suckling Rats: A Comparative Study

Effects of acute hyperglycemia on myocardial glycolytic activity in humans.

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