Effects of guanabenz on bladder function after spinal cord injury

Abstract

To the editor: Sotolongo et al. (Neurourol 8:245-254 [I 9891)Regarding the above article and the published data reported on eight feline spinal cord injury models treated on a dosage of 1.3 mg/kg of guanabenz: Comparing their urodynamic parameters (residual urine, capacity, and detrusor contraction pressure) to a control group of four untreated spinal-cord-injured animals, a significant difference was noted in all parameters between the treated and the untreated groups. In the course of a recent reanalysis of the data, however, it was noted that only three animals actually received the guanabenz at 1.3 mg/kg. In comparing their urodynamic parameters to the recalculated values for the control group, only the bladder capacity showed a trend towards a significant difference between the treatment and the control group.It has become apparent that errors were committed in our laboratory in the identification of the medications used as well as in the recorded dosage administered to the feline models. Two different analogs were used in our laboratory, and therefore the calculation of the published urodynamic parameters was not based on accurate data, since significantly fewer animals than reported actually received the guanabenz at the reported dose.