Effects of guanidine derivatives on the activities of superoxide dismutase and catalase during postischemic reperfusion in the rat brain

Макеева, А. В.; Попова, Т. Н.; Sukhoveeva, O. V.; Панченко, Л. Ф.

doi:10.1134/s1819712410030098

Cited by 6 publications

(1 citation statement)

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“…A state of oxidative stress has deleterious effects on almost all tissues and can initiate or enhance the rate of pathological conditions such as neurodegeneration, inflammation, aging process, cancer and cardiovascular diseases [21,22,23]. Heterocyclic guanidine derivatives have shown remarkable antioxidant properties for reducing the oxidative stress, induced in blood serum and brain tissue by superoxide dismutase and catalase enzymes during ischemia-reperfusion, causing restoration of blood supply and having neuroprotective role [24]. Naturally occurring polycyclic guanidine extracted from the sponge Monanchora unguifera [15] showed significant antitumor properties against several human cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines

et al. 2013

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Abstract:A series of N-pivaloyl-N′-(alkyl/aryl)-N′′-pyridylguanidine of general formula C 4 H 9 CONHC(NR 1 R 2 )NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.

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