Effects of haemodialysis and continuous ambulatory peritoneal dialysis on P300 cognitive potentials in uraemic patients

Tilki, Hacer Erdem; Tekin, Mustafa; Tunali, Gülten; Kara, Atilla; Onar, Musa

doi:10.3109/2000-1967-109

Cited by 46 publications

(37 citation statements)

References 10 publications

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“…Previous investigations of cognitive function among ESRD patients demonstrated that CAPD patient had consistently better cognitive function than HD patients. [14][15][16] In contrast to previous studies, the subjects in this study consisted of patients with ESRD with no clinically evident occurrence of cognitive impairment or dementia. Therefore, cognitive and motor functions were assessed in detail using measures of simple visual discrimination of signal location, short-term memory actualization, simple convergent visual orientation, and convergent thinking.…”

Section: Discussionmentioning

confidence: 99%

“…Some data suggest that the prevalence of cognitive impairment may be different in patients treated with HD compared with patients treated with CAPD. [14][15][16] They also demonstrated that CAPD patients had consistently better cognitive function than HD patients, but the results from these studies may not reflect the dialysis procedure itself but selection bias as to who is receiving which modality.…”

Section: Introductionmentioning

confidence: 99%

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Is There Differences in Cognitive and Motor Functioning between Hemodialysis and Peritoneal Dialysis Patients?

et al. 2011

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Objective: Change in cognitive function is one of the well-known consequences of the end-stage renal disease (ESRD). The aim of this study was to determine the effect of hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) on cognitive and motor functions. Methods: In this cross-sectional study, cognitive and motor functions were investigated in a selected population of 42 patients with ESRD (22 patients on chronic HD and 20 patients on CAPD, aged 50.31 ± 11.07 years). Assessment of cognitive and motor functions was performed by Symbol Digit Modalities Test (SDMT) and Complex Reactiometer Drenovac (CRD-series), a battery of computer-generated psychological tests to measure simple visual discrimination of signal location, short-term memory, simple convergent visual orientation, and convergent thinking. Results: The statistically significant difference in cognitive-motor functions between HD and CAPD patients was not found in any of the time-related parameters in all CRD-series tests or SDMT score. Higher serum levels of albumin, creatinine, and calcium were correlated with better cognitive-motor performance among all patients regardless of dialysis modality. The significant correlation between ultrafiltration rate per HD and short-term memory actualization test score (CRD-324 MT) among HD patients was found (r = 0.434, p = 0.025). Conclusion:This study has demonstrated that well-nourished and medically stable HD and CAPD patients without clinical signs of dementia or cognitive impairment and without significant difference in age and level of education performed all tests of cognitive-motor abilities without statistically significant difference.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is There Differences in Cognitive and Motor Functioning between Hemodialysis and Peritoneal Dialysis Patients?

et al. 2011

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“…18 In patients undergoing peritoneal dialysis, the few available data suggest that the prevalence of cognitive impairment might be lower than in hemodialysis patients. 19,20 However, this apparent discrepancy may reflect selection bias (because the dialysis procedure will depend on the patients' characteristics and thus cognitive function before the introduction of dialysis 21 ) rather than the procedure's characteristics per se.…”

Section: Patients With Stage 5 Ckdmentioning

confidence: 99%

Cognitive Disorders and Dementia in CKD

Bugnicourt

Godefroy

Chillon

et al. 2013

Journal of the American Society of Nephrology

494

431

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Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including direct neuronal injury by uremic toxins, could also be involved, especially in the absence of obvious cerebrovascular disease. We discuss the prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors. Understanding the pathophysiologic interactions between renal impairment and brain function is important in order to minimize the risk for future cognitive impairment.

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“…ERPs have been used to study the effects of hemodialysis on ESRD patients [13][14][15][16] ; however, many of these previous studies have failed to take into account various co-morbidities (such as coronary artery disease, diabetes mellitus, cerebrovascular disease, anemia, malnutrition etc.) that may contribute to cognitive dysfunction in these patients.…”

Section: Introductionmentioning

confidence: 99%