Effects of harman and harmine on naloxone-precipitated withdrawal syndrome in morphine-dependent rats

Aricioglu-Kartal, F.; Uzbay, I.T.

doi:10.1016/s0924-977x(01)80485-5

Cited by 9 publications

(13 citation statements)

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“…The β-carbolines exert a plenty of neurophysiological effects such as competitive inhibition of monoamines uptake, inhibition of Na + -dependent ATPases, among others (for a review, see McKenna, 2004). Interestingly, harman and harmine attenuated some signs of naloxoneprecipitated morphine withdrawal syndrome (Aricioglu-Kartal, Kayir, Uzbay, 2003), what corroborate with the hypothesis that these alkaloids may modulate the opioid system. The authors suggested that the beneficial effects may be mediated by imidazoline receptors, what was later evaluated by Miralles et al (2005) that demonstrated the β-carbolines bind with high affinity to imidazoline I2B receptors.…”

Section: Treatment and Doses (Mg/kg)supporting

confidence: 58%

Pre-clinical interaction of ayahuasca, a brew used in spiritual movements, with morphine and propofol

Pires

Mendes

Pires

et al. 2018

Braz. J. Pharm. Sci.

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Ayahuasca is a beverage with psychoactive properties used in religious and ceremonial rituals by some religious groups. The main active components of ayahuasca are dimethyltryptamine and the harmala alkaloids with β-carboline structure acting as monoamine oxidase A inhibitors. This combination produces a pronounced activation of serotonergic pathways and presents potential interaction with other psychotropics. The objective of this study was to investigate the possible interactions between ayahuasca and agents employed in general anesthesia. The pharmacological interactions between ayahuasca and morphine or propofol were evaluated in mice using doses of 12, 120 and 1200 mg/kg (0.1 to 10 times the average dose consumed by humans in religious rituals). Ayahuasca alone showed an antinociceptive effect in the writhing and formalin tests, and intensified the analgesic effect of morphine in the hot plate test. Concerning the pharmacological interactions between ayahuasca and propofol, the results were opposite; ayahuasca intensified the depressant effect of propofol in the rotarod test, but decreased the sleeping time induced by propofol. These set of results showed the occurrence of some interactions between ayahuasca and the drugs morphine and propofol, possibly by both pharmacokinetics and pharmacodynamics mechanisms.

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Section: Treatment and Doses (Mg/kg)supporting

confidence: 58%

Pre-clinical interaction of ayahuasca, a brew used in spiritual movements, with morphine and propofol

Pires

Mendes

Pires

et al. 2018

Braz. J. Pharm. Sci.

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“…Analysis of the autoradiograms showed a highly significant correlation between the distribution of [ 3 (Anderson et al, 2006b). I 2 receptor ligands have been shown to alleviate some behaviors associated with naloxone-precipitated morphine withdrawal in rats (Hudson et al, 1999a), and harmane is also able to mimic these affects presumably via I 2 receptors (Aricioglu-Kartal et al, 2003). We now know that I 2 receptors play a role in chronic pain, and harmane is reported to show antinociceptive activity comparable to I 2 receptor-selective ligands Aglawe et al, 2014).…”

Section: B Harmanementioning

confidence: 94%

Imidazoline Receptor System: The Past, the Present, and the Future

et al. 2019

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“…At the doses administered, neither reduced animal locomotor activity in naïve or morphine‐dependent rats. Imidazoline receptors were also speculated to be involved (Aricioglu‐Kartal et al ., ). No positive control was applied.…”

Section: Plant Bioactive Componentsmentioning

confidence: 97%

Phytotherapy of Opioid Dependence and Withdrawal Syndrome: A Review

Tabatabai

Dashti

Doosti

et al. 2013

Phytotherapy Research

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Development of tolerance and dependence is a major problem associated with opioid treatment. Withdrawal syndrome is common between medical and illicit users of these agents. Phytomedicine has shown promise in the treatment of this complicated psychosomatic condition. In this study, the effects of plant extracts and active components on morphine dependence and withdrawal syndrome are discussed. Proper keywords were used to search through PubMed, Google Scholar, and SciVerse, as well as two local scientific databases, www.iranmedex.com and www.SID.com. All relevant results (original articles, meeting abstracts, patents, etc.) published from 2000 to 2013 were chosen for final review. A total of 35 plant species were studied on this subject. Plants from Lamiaceae, Ranunculaceae, and Apiaceae families were especially effective. A few studies were carried out on human subjects and the rest in animal models. Opioid dependence and withdrawal syndrome remain an intimidating challenge. Nonetheless, plants and their derivatives are suitable sources for their treatment. Although there are several plants shown to be effective in animal models, few clinical studies are available.

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Effects of harman and harmine on naloxone-precipitated withdrawal syndrome in morphine-dependent rats

Cited by 9 publications

References 0 publications

Pre-clinical interaction of ayahuasca, a brew used in spiritual movements, with morphine and propofol

Pre-clinical interaction of ayahuasca, a brew used in spiritual movements, with morphine and propofol

Imidazoline Receptor System: The Past, the Present, and the Future

Phytotherapy of Opioid Dependence and Withdrawal Syndrome: A Review

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