Effects of Heat Stress on Gut-Microbial Metabolites, Gastrointestinal Peptides, Glycolipid Metabolism, and Performance of Broilers

Wang, Guangju; Li, Xiumei; Zhou, Ying; Feng, Jinghai; Zhang, Min-Hong

doi:10.3390/ani11051286

Cited by 34 publications

(24 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, all the relevant data reported were cross-checked with the literature and showed no discrepancies in the current study. For example, the recorded growth performances of Arbor Acres in this study were concordant to recently published articles [59,60]. In addition, the average BWs obtained after hatch (45.1 g), 7 days (165.7 g), 21 days (981.1 g), and 28 days (1624.1 g) were in line with the Arbor Acres broiler performances (as-hatched performance) objective, which recommends 43 g, 204 g, 978 g, and 1567 g for the same periods, respectively [61].…”

Section: Discussionsupporting

confidence: 91%

Effects of In Ovo Feeding of γ-Aminobutyric Acid on Growth Performances, Plasma Metabolites, and Antioxidant Status in Broilers Exposed to Cyclic Heat Stress

et al. 2021

View full text Add to dashboard Cite

γ-aminobutyric acid (GABA) is an amino acid used for mitigating the detrimental effects of heat stress in broilers. In addition, a growing body of literature suggests that the in ovo feeding of various nutrients can enhance the post-hatch thermotolerance of broilers. Therefore, we hypothesized that the supplementation of GABA during incubation might have positive effects in heat-stressed broilers. Chicks hatched from eggs were divided into three groups described as follows: chicks hatched from eggs incubated at normal temperature and then raised under thermoneutral temperature (CON); chicks hatched from eggs incubated at normal temperature but raised under cyclic heat stress (HS) (CON+HS); and chicks hatched from eggs injected with 60 mg of GABA dissolved in 0.6 mL of distilled water but raised under cyclic HS (G10+HS). The HS was applied between 28 and 31 days of age with ambient temperatures raised from 22 ± 1 °C to 33 ± 1 °C for 6 h daily. Compared to the CON group, average daily weight gain was significantly lower in the CON+HS but not in the G10+HS group. Feed intake was significantly decreased in both the CON+HS and G10+HS groups. Compared to the CON group, plasma corticosterone levels were significantly increased in the CON+HS group, but not the G10+HS group. Hepatic mRNA levels of the acetyl-CoA carboxylase gene (ACC) were significantly reduced in the G10+HS group compared to the CON group. In addition, positive Pearson correlation coefficients were found in mRNA levels between fatty acid synthase (FAS) and nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1) (r = 0.55, p < 0.05), NOX1 and NOX4 (r = 0.65, p < 0.01), and catalase (CAT) and superoxide dismutase (SOD) (r = 0.62, p < 0.05). Taken together, the results suggest that this study can serve as a basis for future work focusing on the in ovo feeding of GABA as a technique to combat heat stress in broilers.

show abstract

Section: Discussionsupporting

confidence: 91%

Effects of In Ovo Feeding of γ-Aminobutyric Acid on Growth Performances, Plasma Metabolites, and Antioxidant Status in Broilers Exposed to Cyclic Heat Stress

et al. 2021

View full text Add to dashboard Cite

show abstract

“…At the family level, the proportions of Christensenellaceae, Clostridiaceae, and Erysipelotrichaceae increased; these bacteria were reported to be beneficial to normal glucose metabolism, alleviate insulin resistance, and lower the risk of obesity [ 30 , 31 ]. Our previous study showed that the abundance of Christensenellaceae was significantly reduced by heat stress, while the abundance of Christensenellaceae was significantly increased in the 0.4 mg/kg supplemented group [ 8 ], indicating that glucose metabolism in the chromium supplement group improved. At the genus level, the proportion of Ruminococcus decreased.…”

Section: Discussionmentioning

confidence: 99%

“…The gut releases hormones to regulate glucose metabolism and balance glucose homeostasis when feeding. Our previous research indicated that high temperature significantly affects the levels of CCK, ghrelin, and GIP [ 8 ]. In the current study, the results showed that 0.4 mg/kg Cr as supplemented Cr-Pic decreased the levels of CCK in the jejunum and circulation, increasing the GIP level in the jejunum.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study observed a state of insulin resistance in human hyperthermia [ 7 ]. Our previous research found that heat stress caused insulin resistance in broilers [ 8 ]. High temperature leads to reduced glucose absorption efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, excessive temperature impacts the composition of the gut microbial community and gastrointestinal peptides. Our previous research suggested that high temperature significantly alters the proportion of bacteria and abundance of metabolites and that the concentrations of several gastrointestinal peptides changed owing to excessive temperature [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Dietary Chromium Picolinate on Gut Microbiota, Gastrointestinal Peptides, Glucose Homeostasis, and Performance of Heat-Stressed Broilers

Wang

Zhou

et al. 2022

Animals

Self Cite

View full text Add to dashboard Cite

The current research was devoted to evaluating the effects on gut microbiota, gastrointestinal peptides, and glucose homeostasis of chromium picolinate applied to heat-stressed broilers. In a 14 d experiment, 220 28-day-old AA broilers were randomly assigned into one thermal-neutral and three high-temperature groups dietary-supplemented with 0, 0.4, or 0.8 mg/kg of chromium as chromium picolinate. The temperature for the thermal-neutral group was set at 21 °C, while that for the other three groups (high temperature) was set at 31 °C. The results showed that the average daily gain and average daily feed intake of the 0.4 mg/kg chromium-supplemented group significantly increased compared with the high-temperature groups (p < 0.05). The content of cholecystokinin in the 0.4 mg/kg group significantly decreased, and the gastric inhibitory polypeptide level was significantly elevated in jejunum (p < 0.05). The cecal microbiota of heat-stressed broilers was substantially different from that of the thermal-neutral group. After diet-supplemented chromium, compared to the high-temperature groups, the 0.4 mg/kg chromium supplemented group was characterized by a reduction of Actinobacteriota and Proteobacteria at the phylum level. The Bacilli were elevated, while proportions of Coriobacteria and Gammaproteobacteria were reduced significantly at the class level. The proportions of Lactobacillaceae, Christensenellaceae, and Erysipelotrichaceae were elevated significantly, while that of Clostridiaceae was reduced significantly at the family level. The proportion of Turicibacter was elevated significantly and the proportions of Olsenella and Ruminococcus were reduced significantly at the genus level (p < 0.05). Compared to the high-temperature groups, in the 0.4 mg/kg chromium-supplemented group, the insulin concentration and insulin resistance index were reduced (p < 0.05), and sodium-glucose transporter 1 expression was up-regulated in jejunum (p < 0.05). Performance, microbiota, gastrointestinal peptides, or serum parameters of the 0.8 mg/kg group were almost unaffected by chromium compared with the high-temperature groups. In conclusion, diet supplemented with 0.4 mg/kg Cr improved performance, insulin resistance and sodium-glucose transporter 1 expression and altered gut microflora structure and secretion of gastrointestinal peptides, thus showing that supplementation with chromium is beneficial to maintain glucose homeostasis and alleviate heat stress.

show abstract

Probiotic strategies for mitigating heat stress effects on broiler chicken performance

Aydin,

Hatipoglu

2024

Int J Biometeorol

View full text Add to dashboard Cite

Effects of Heat Stress on Gut-Microbial Metabolites, Gastrointestinal Peptides, Glycolipid Metabolism, and Performance of Broilers

Cited by 34 publications

References 57 publications

Effects of In Ovo Feeding of γ-Aminobutyric Acid on Growth Performances, Plasma Metabolites, and Antioxidant Status in Broilers Exposed to Cyclic Heat Stress

Effects of In Ovo Feeding of γ-Aminobutyric Acid on Growth Performances, Plasma Metabolites, and Antioxidant Status in Broilers Exposed to Cyclic Heat Stress

Effects of Dietary Chromium Picolinate on Gut Microbiota, Gastrointestinal Peptides, Glucose Homeostasis, and Performance of Heat-Stressed Broilers

Probiotic strategies for mitigating heat stress effects on broiler chicken performance

Contact Info

Product

Resources

About