Effects of heat stress on the renal and branchial carbohydrate metabolism and antioxidant system of Antarctic fish

Abstract

The objective of the present study was to assess the effect of short-term (2-144 h) heat stress (8 °C) on energy production processes and antioxidant defense systems in the kidneys and gills of Notothenia rossii and Notothenia coriiceps. Heat stress affected energy metabolism and oxidative stress parameters in a time-, tissue-, and species-dependent manner, and gills were more sensitive than kidneys to heat stress. N. rossii kidneys were able to stabilize carbohydrate metabolism after 12 h of heat stress, whereas the glycogen levels in N. coriiceps kidneys fluctuated in response to varying glucose-6-phosphatase (G6Pase) levels. The gills of N. rossii were able to stabilize their energy demand and aerobic metabolism under heat stress, whereas in the gills of N. coriiceps, changes in carbohydrate metabolic pathways depended on the exposure time: initially, anaerobiosis was activated after 6 h; the energy demand, characterized by glycogen consumption, increased after 72 h, and aerobic metabolism was activated within 144 h. With regard to the antioxidant defenses of the N. rossii kidney, it was found that levels of antioxidant enzymes were reduced during the first hours of heat stress, contributing to increased lipid peroxidation, whereas N. coriiceps kidneys did not show signs of oxidative damage. The gills of N. rossii exhibited more pronounced oxidative damage in response to heat stress than those of N. coriiceps despite the presence of increasing levels of antioxidants, likely due to tissue hypoxia.

Association between ambient air pollution exposure and infants small for gestational age in Huangshi, China: a cross-sectional study

“…The increased risk of SGA in summer may be the result of high-temperature exposure. Heat stress could cause damage to the antioxidant defense system and result in a larger secretion amount of oxytocin (Forgati et al 2017), which could have a negative impact on maternal health and fetal growth. The association in winter could be explained by a deficiency in vitamin D. Vitamin D has been found to be negatively correlated to SGA risk (Wang et al 2018), and the level of vitamin D in winter in China is much lower than that in summer (Yang and Zhang 2013).…”

Effects of season of birth and meteorological parameters on serum bilirubin levels during the early neonatal period: a retrospective chart review

“…As pregnant women are particularly sensitive to meteorological conditions and environmental exposure [5], the period before delivery could be a critical window in uencing fetal growth when high or low ambient temperature exposure occurs [23]. In summer, heat stress can damage antioxidant defense systems and lead to increased oxytocin secretion [24]. In winter, decreased sunlight exposure may lead to lower levels of vitamin D [25], which is essential for normal placental function and fetal growth [26].…”

Transcriptome Analysis of Yamame (Oncorhynchus masou) in Normal Conditions after Heat Stress

“…Other genes expressed by heat stress, such as activator protein 1 (AP-1), CCAAT enhancer binding protein beta (CEBP), IKBA, and NF-kB, exert major effects by inducing inflammation, apoptosis, and cell survival [43]. Several studies have reported that heat stress affects glucose and lipid metabolism, which may help to maintain energy homeostasis in fish [7,44].…”

“…p73, which is a component in the direct negative feedback loop in the p53 signaling pathway [5,17], was more highly expressed in the HT group compared to the NT group, suggesting that it may have suppressed p53 activities by repression or competition of p53 transcriptional activation. Meanwhile, thrombospondin-1 (TSP1), which is important for interfacing with stress signals to inform stress responses in tissue [44,48], was less expressed in the HT group than in the NT group. The CD82 antigen, KAI, is a member of the tetraspanin protein family that regulates cell motility, morphology, signaling, and cell survival [49,50], and this antigen was also expressed at lower levels in the HT group.…”