DZ22B alloy is commonly used as a blade material for aircraft engines and gas turbines, and its preparation process is an important factor affecting its performance. In the present work, a reliable numerical model is established through ProCAST numerical simulation and auxiliary experimental verification methods, based on which the effect of casting speed on the grain and dendrite growth of DZ22B superalloy blades is studied. The results indicate that increasing the pulling speed can reduce the spacing between secondary dendrites, which is beneficial for the growth of dendrites. Based on numerical simulation and experimental verification, it is suggested that the pulling rate of the directional solidification DZ22B superalloy blade should be 6-2mm/min variable speed pulling to improve the production success rate.