Solutions based on artificial intelligence and brain-inspired computations like Artificial Neural Networks (ANNs) are suited to deal with the growing computational complexity required by state-of-the-art electronic devices. Many applications that are being deployed using these computational models are considered safety-critical (e.g., self-driving cars), producing a pressing need to evaluate their reliability. Besides, state-of-the-art ANNs require significant memory resources to store their parameters (e.g., weights, activation values), which goes outside the possibility of many resourceconstrained embedded systems. In this light, Approximate Computing (AxC) has become a significant field of research to improve memory footprint, speed, and energy consumption in embedded and high-performance systems. The use of AxC can significantly reduce the cost of ANN implementations, but it may also reduce the inherent resiliency of this kind of application. On this scope, reliability assessments are carried out by performing fault injection test campaigns. The intent of the paper is to propose a framework that, relying on the results of radiation tests in Commercial-Off-The-Shelf (COTS) devices, is able to assess the reliability of a given application. To this end, a set of different radiation-induced errors in COTS memories is presented. Upon these, specific fault models are extracted to drive emulation-based fault injections.