Background: The ability of a loop to generate a certain moment/force ratio (M/F ratio) can achieve the desired tooth movement in orthodontics. The present study aimed to investigate the effects of elastic modulus, crosssectional dimensions, loop configuration geometry dimensions, and activation force on the generated M/F ratio of vertical, L-and T-loops.Methods: A total of 120 three-dimensional loop models were constructed with the Solidworks 2017 software and used for simulating loop activation with the Abaqus 6.14 software. Six vertical loop variations, 9 L-loop variations, and 9 T-loop variations were evaluated. In each group, only one parameter was variable [loop height, ring radius, leg length, leg step distance, legs distance, upper length, different archwire materials (elastic modulus), crosssectional dimension, and activation force].Results: The simulation results of the displacement and von Mises stress of each loop were investigated. The maximum displacement in the height direction was recorded to calculate the M/F ratio. The quantitative change trends in the generated M/F ratio of the loops with respect to various variables were established.Conclusions: Increasing the loop height can increase the M/F ratio of the loop. This increasing trend is, especially, much more significant in T-loops compared with vertical loops and L-loops. In vertical loops, increasing the ring radius is much more effective than increasing the loop height to increase the M/F ratio of the loop. Compared with SS, TMA archwire loops can generate a higher M/F ratio due to its lower elastic modulus. Loops with a small crosssectional area and high activation force can generate a high M/F ratio. The introduction of a leg step to loops does not increase the M/F ratio of loops.