Effects of hematocrit on thixotropic properties of human blood

Huang, Ching‐Rong; Chen, H.Q.; Pan, W.D.; Shih, Tzu Ching; Kristol, D.; Copley, Alfred L.

doi:10.3233/bir-1987-24631

Cited by 13 publications

(8 citation statements)

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“…Such constraints strongly restrict the freedom in interpretation of experimental data because the models have to fit them in a broad range of shear rate using the same set of parameters. From different empirical/semi-empirical equations describing the shear rate-dependent non-Newtonian fluid flow behavior, found in the literature [5,8,12,32], in the presented paper we have chosen three of the best known ones: Casson, Ree-Eyring and Quemada [20,23,25].…”

Section: Introductionmentioning

confidence: 99%

Comparison of three rheological models of shear flow behavior studied on blood samples from post-infarction patients

Marcinkowska‐Gapińska

Gapiński

Elikowski³

et al. 2007

Med Bio Eng Comput

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Quantitative analysis of blood viscosity was performed on the basis of mathematical models of non-Newtonian fluid shear flow behavior (Casson, Ree-Eyring and Quemada). A total of 100 blood samples were drawn from clinically stable survivors of myocardial infarction, treated with aspirin or acenocoumarol and controls to these drugs. Whole blood and plasma viscosity were measured at a broad range of shear rates using a rotary-oscillating viscometer Contraves LS40. Numerical analysis of the experimental data was carried out by means of linear (for Casson) and non-linear regression for the remaining models. In the evaluation of the results, both the fit quality and physical interpretation of the models' parameters were considered. The Quemada model fitted most precisely with the experimental findings and, despite the controversies concerning the relationship between in vivo tissue perfusion and in vitro rheological measurements, seemed to be a valuable method enhancing investigation possibilities of cardiovascular patients. Our results suggest that aspirin does not affect blood rheological properties, while acenocoumarol may slightly alter red cell deformability and rouleaux formation.

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Section: Introductionmentioning

confidence: 99%

Comparison of three rheological models of shear flow behavior studied on blood samples from post-infarction patients

Marcinkowska‐Gapińska

Gapiński

Elikowski³

et al. 2007

Med Bio Eng Comput

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“…It is due to the process of breaking up rouleaux into individual erythrocytes. (Baskurt et al, 2007;Huang et al, 1987) The binding of alginate microspheres to each other appears to be more pronounced than in RBCs. This effect has also been observed in other blood substitute models (Carneiro et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Flow Study on a Transparent Two-Phase Blood Model Fluid Based on Alginate Microspheres

Froese

Gabel

Parnell

et al. 2022

Preprint

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The reduction of blood damage is still a big challenge in blood-carrying medical devices. In-vitro experiments are performed to investigate the damage-causing effects, but due to the opaqueness of blood cells, only near-wall flows can be observed. Thus, several transparent blood models to visualize the rheologic behavior of blood have been proposed and examined. Nevertheless, two-phase blood models with added particles still represent the properties of blood inadequately or are very expensive and complex to produce. In this in-vitro study, the viscosity, the flow behavior and the cell deformation of human red blood cells (RBCs) have been compared to a novel, easy-to-produce, two-phase blood model fluid with deformable alginate microspheres. The comparison has been performed in a cone-plate rheometer, a straight and a hyperbolic converging microchannel. The viscosity of the blood model fluid with a particle fraction of 30 % showed a shear-thinning behavior, comparable to that of blood at room and human body temperature within shear rates from 7 s-1 to 2000 s-1. The alginate microspheres were deformable in an extensional flow and formed a cell free layer (CFL) comparable to that of blood in a straight microchannel. The experiments showed a good optical accessibility of the two-phase flow with traceable movements of individual microspheres in the center of the microchannel. It could be shown that our proposed blood model fluid is a promising tool for the analysis of two-phase flows in complex flow geometries.

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“…It is due to the process of breaking up rouleaux into individual erythrocytes. (Baskurt et al 2007;Huang et al 1987) The binding of alginate microspheres to each other appears to be more pronounced than in RBCs. This effect has also been observed in other blood substitute models (Carneiro et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Flow study on a transparent two-phase blood model fluid based on alginate microspheres

et al. 2022

View full text Add to dashboard Cite

The reduction of blood damage is still a big challenge in blood-carrying medical devices. In vitro experiments are performed to investigate the damage-causing effects, but due to the opaqueness of blood cells, only near-wall flows can be observed. Thus, several transparent blood models to visualize the rheologic behavior of blood have been proposed and examined. Nevertheless, two-phase blood models with added particles still represent the properties of blood inadequately or are very expensive and complex to produce. In this in vitro study, the viscosity, the flow behavior and the cell deformation of human red blood cells have been compared to a novel, easy-to-produce, two-phase blood model fluid with deformable alginate microspheres. The comparison has been performed in a cone-plate rheometer, a straight and a hyperbolic converging microchannel. The viscosity of the blood model fluid with a particle fraction of 30% showed a shear-thinning behavior, comparable to that of blood at room and human body temperature within shear rates from 7 to $$2000\,\hbox {s}^{-1}$$ 2000 s - 1 . The alginate microspheres were deformable in an extensional flow and formed a cell free layer comparable to that of blood in a straight microchannel. The experiments showed a good optical accessibility of the two-phase flow with traceable movements of individual microspheres in the center of the microchannel. It could be shown that our proposed blood model fluid is a promising tool for the analysis of two-phase flows in complex flow geometries. Graphical Abstract

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Effects of hematocrit on thixotropic properties of human blood

Cited by 13 publications

References 0 publications

Comparison of three rheological models of shear flow behavior studied on blood samples from post-infarction patients

Comparison of three rheological models of shear flow behavior studied on blood samples from post-infarction patients

Flow Study on a Transparent Two-Phase Blood Model Fluid Based on Alginate Microspheres

Flow study on a transparent two-phase blood model fluid based on alginate microspheres

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