Effects of hemodialysis and longterm erythropoietin treatment on protein C, and on free and total protein S

Clyne, Naomi; Egberg, Nils; Lins, Lars‐Eric

doi:10.1016/0049-3848(95)00162-k

Cited by 11 publications

(4 citation statements)

References 20 publications

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“…As a result, clinical guidelines from Kidney Disease: Improving Global Outcomes (KDIGO) no longer recommend warfarin therapy for stroke prevention in AF among dialysis patients [90]. It is plausible that frequent heparinization during hemodialysis, reduced levels of protein C, protein S and antithrombin III [91–95], as well as the fluctuations in blood pressure in hemodialysis patients with AF might diminish the overall benefit of warfarin due to a higher thrombotic and bleeding risk. Nonetheless, good‐quality anticoagulation control with high TTR may mitigate risks [96].…”

Section: Role Of Vitamin K Antagonists (Vkas)mentioning

confidence: 99%

2017 consensus of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation

Chiang

Okumura

Zhang

et al. 2017

Journal of Arrhythmia

157

193

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Atrial fibrillation (AF) is the most common sustained arrhythmia, causing a 2-fold increase in mortality and a 5-fold increase in stroke. The Asian population is rapidly aging, and in 2050, the estimated population with AF will reach 72 million, of whom 2.9 million may suffer from AF-associated stroke. Therefore, stroke prevention in AF is an urgent issue in Asia. Many innovative advances in the management of AF-associated stroke have emerged recently, including new scoring systems for predicting stroke and bleeding risks, the development of non-vitamin K antagonist oral anticoagulants (NOACs), knowledge of their special benefits in Asians, and new techniques. The Asia Pacific Heart Rhythm Society (APHRS) aimed to update the available information, and appointed the Practice Guideline sub-committee to write a consensus statement regarding stroke prevention in AF. The Practice Guidelines sub-committee members comprehensively reviewed updated information on stroke prevention in AF, emphasizing data on NOACs from the Asia Pacific region, and summarized them in this 2017 Consensus of the Asia Pacific Heart Rhythm Society on Stroke Prevention in AF. This consensus includes details of the updated recommendations, along with their background and rationale, focusing on data from the Asia Pacific region. We hope this consensus can be a practical tool for cardiologists, neurologists, geriatricians, and general practitioners in this region. We fully realize that there are gaps, unaddressed questions, and many areas of uncertainty and debate in the current knowledge of AF, and the physician׳s decision remains the most important factor in the management of AF.

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Section: Role Of Vitamin K Antagonists (Vkas)mentioning

confidence: 99%

2017 consensus of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation

Chiang

Okumura

Zhang

et al. 2017

Journal of Arrhythmia

157

193

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“…Similarly, Alwakeel et al [28] reported a marked diminution in the circulating levels of coagulation inhibitors in HD compared to PD patients. Several studies have demonstrated that rHuEPO might shift the precarious balance of the hemostatic system towards thrombosis whereas not all the studies confirm this [6,[30][31][32][33][34][35][36]. In our study all patients in both dialysis groups were receiving rHuEPO treatment.…”

Section: Discussionmentioning

confidence: 63%

Protein Z and natural anticoagulants in children on peritoneal dialysis and hemodialysis

et al. 2007

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Hemostatic alterations due to abnormalities in the coagulation and fibrinolytic system may occur in dialysis patients. Protein Z (PZ) is a vitamin K-dependent coagulation protein promoting assembly of thrombin with phospholipid vesicles. The aim of this study was to investigate PZ and natural anticoagulants in children on hemodialysis (HD) and peritoneal dialysis (PD). Protein Z, protein C (PC), protein S (PS), antithrombin III (AT III), and fibrinogen levels were studied in 24 PD, 13 HD patients and 23 controls. Plasma PZ levels in patients on HD were significantly higher than those on PD and control group (p = 0.04, p = 0.03). We observed elevated PC, PS and AT III activities in children on PD when compared to controls (p = 0.011, p = 0.003, p < 0.001). In HD patients, only PS activity was increased compared to controls (p = 0.016). PC and PS activities did not differ between PD and HD patients whereas AT III activity was higher in PD patients compared to HD patients (p < 0.001). Normal/high levels of PC, PS and AT III suggest that children on PD or HD treatment do not seem to have an increased risk of thrombogenesis due to reduction of these proteins. Increased PZ levels, however, might contribute to the hemostatic alterations in children on HD treatment along with other well known abnormalities.

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“…More than 50% of males and 30% of females have been shown to experience sexual dysfunction during conventional antipsychotic treatment [66]. The amount of hyperprolactinemia that contributes to sexual dysfunction during treatment with antipsychotics is undetermined, but there is some indication that sexual dysfunction worsens with serum prolactin elevation [66][67][68][69].…”

Section: Discussionmentioning

confidence: 98%

Safety of Cabergoline in the Management of Pituitary Prolactin-Induced Symptoms with Patients Treated with Atypical Neuroleptics

Coronas¹,

Cobo

Giménez-Palop³

et al. 2012

CDS

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Effects of hemodialysis and longterm erythropoietin treatment on protein C, and on free and total protein S

Cited by 11 publications

References 20 publications

2017 consensus of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation

2017 consensus of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation

Protein Z and natural anticoagulants in children on peritoneal dialysis and hemodialysis

Safety of Cabergoline in the Management of Pituitary Prolactin-Induced Symptoms with Patients Treated with Atypical Neuroleptics

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