Effects of Hemoglobin Concentration, Skull Thickness, and the Area of the Cerebrospinal Fluid Layer on Near-infrared Spectroscopy Measurements

Yoshitani, Kenji; Kawaguchi, Masahiko; Miura, Norikazu; Okuno, Takashi; Kanoda, Tomoko; Ohnishi, Yoshihiko; Kuro, Masakazu

doi:10.1097/00000542-200703000-00009

Cited by 153 publications

(105 citation statements)

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“…Using the NIRO 300 in the controlled environment of carotid endarterectomy, it has been demonstrated that the tissue oxygenation index (TOI) is sensitive to changes in hemispheric, intracerebral blood supply and is little affected by extracranial contamination [3]. The TOI has also been shown to be independent of hemoglobin concentration, skull thickness, and the area of the cerebrospinal fluid layer underlying the optodes [4].…”

Section: Abpmentioning

confidence: 99%

Near-Infrared Spectroscopy can Monitor Dynamic Cerebral Autoregulation in Adults

et al. 2008

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Objective To study the correlation between a dynamic index of cerebral autoregulation assessed with blood flow velocity (FV) using transcranial Doppler, and a tissue oxygenation index (TOI) recorded with near-infrared spectroscopy (NIRS). Methods Twenty-three patients with sepsis, severe sepsis, or septic shock were monitored daily on up to four consecutive days. FV, TOI, and mean arterial blood pressure (ABP) were recorded for 60 min every day. An index of autoregulation (Mx) was calculated as the moving correlation coefficient between 10-s averaged values of FV and ABP over moving 5 min time-windows. The index Tox was evaluated as the correlation coefficient between TOI and ABP in the same way. The indices Mx and Tox, ABP and arterial partial pressure of CO 2 were averaged for each patient. Results Synchronized slow waves, presenting with periods from 20 s to 2 min, were seen in the TOI and FV of most patients, with a reasonable coherence between the signals in this bandwidth (coherence >0.5). The indices, Mx and Tox, demonstrated good correlation with each other (R = 0.81; P < 0.0001) in the whole group of patients. Both indices showed a significant (P < 0.05) tendency to indicate weaker autoregulation in the state of vasodilatation associated with greater values of arterial partial pressure of CO 2 or lower values of ABP. Conclusion NIRS shows promise for the continuous assessment of cerebral autoregulation in adults.

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Section: Abpmentioning

confidence: 99%

Near-Infrared Spectroscopy can Monitor Dynamic Cerebral Autoregulation in Adults

et al. 2008

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“…Similar to EEG and TCD, near-infrared spectroscopy (NIRS) provides real-time, continuous information regarding cerebral perfusion, in a non-invasive manner 8,52 . By measuring the concentrations of oxygenated haemoglobin (oxyHb) and deoxygenated haemoglobin (deoxyHb), regional cerebral oxygen saturation (rSO 2 ) is determined 37,52,53 .…”

Section: Non-invasive Neuromonitoringmentioning

confidence: 99%

“…By measuring the concentrations of oxygenated haemoglobin (oxyHb) and deoxygenated haemoglobin (deoxyHb), regional cerebral oxygen saturation (rSO 2 ) is determined 37,52,53 . An rSO 2 value greater than 20% below the baseline is indicative of cerebral hypoperfusion and should prompt immediate intervention to improve cerebral oxygenation, and thus prevent cerebral injury 8,12,13,36,51,53 .…”

Section: Non-invasive Neuromonitoringmentioning

confidence: 99%

“…Measurement of the absorption ratios at two different sites allows for the removal of the extracranial contribution via a subtraction algorithm, thus giving a mean value for cerebral saturation 10, 52,54,55 . In order to generate an rSO 2 value, cerebral oximetry makes several assumptions.…”

Section: Invos ® 5100c Cerebral/somatic Oximetermentioning

confidence: 99%

“…(Hb) within the cerebral vascular bed, regional cerebral oxygen saturation (rSO 2 ) can be determined 12,52 .…”

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Use of near‐infrared spectroscopy to identify trends in regional cerebral oxygen saturation in horses

McConnell

Rioja

Bester

et al. 2012

Equine Veterinary Journal

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Summary Reasons for performing study Alterations in cerebral haemodynamics may contribute to perianaesthetic complications in horses. Near‐infrared spectroscopy (NIRS) is frequently used intraoperatively in man to provide information regarding cerebral perfusion. Objectives To determine whether NIRS can identify trends in regional cerebral oxygen saturation (rSO2) in horses and whether there is a correlation between rSO2 and venous oxygen tensions. Methods A cerebral oximeter sensor recorded rSO2 from the dorsal sagittal sinus of 6 healthy horses. Values for rSO2, arterial and venous oxygen and carbon dioxide tensions (PaO2, PvO2, PaCO2 and PvCO2 respectively), along with arteriovenous oxygen saturations (SavO2) were recorded in unsedated (recording period [RP] 1), sedated (RP2) and anaesthetised horses (RP3–5) and during recovery (RP6–8). During anaesthesia, horses were ventilated to achieve states of normo‐ (RP3), hyper‐ (RP4) and hypocapnoea (RP5). Data were evaluated descriptively and analysed using linear mixed‐effects models and Pearson's correlation coefficient. Results Overall mean ± s.d. values for rSO2, PaO2, PvO2, PaCO2, SavO2 and mean arterial pressure varied significantly by RP (P<0.001). Significant decreases in rSO2 were identified between RP1 and the post anaesthetic periods (P<0.001). No significant differences in rSO2 values were identified between RP1 and the intra‐anaesthesia periods or between RP3, RP4 and RP5. Significant correlations were identified between rSO2 and PaO2 (r = 0.448, P<0.001), rSO2 and PvO2 (r = 0.512, P<0.001) and rSO2 and SavO2 (r = 0.469, P<0.001). Conclusions This is the first study to identify trends in rSO2 in horses using NIRS. A positive correlation was identified between rSO2 and PvO2, suggesting that alterations in cerebral oxygenation may be reflected in PvO2. Potential relevance Near‐infrared spectroscopy may be used to monitor trends in rSO2 during equine anaesthesia. Decreasing rSO2 values may act as an early warning signal, alerting clinicians to potential cerebral desaturation events and indicating a need for intervention.

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Diagnosis of skin and soft tissue infections using near‐infrared spectroscopy

Maruhashi

Kumazawa

et al. 2021

Acute Medicine & Surgery

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Aim Skin and soft tissue infections are classified into cellulitis and necrotizing fasciitis, which are difficult to distinguish. Necrotizing fasciitis has a poor prognosis and requires immediate intensive care. The diagnostic gold standard is to incise the lesion to determine whether necrosis has reached the fascia. We aimed to show that these infections can be differentiated using near‐infrared spectroscopy. Methods We describe two cases in an observational study about the utility of near‐infrared spectroscopy. Case 1 involved a 77‐year‐old man with a chief complaint of pain, redness, and swelling in the right lower leg for 1 week. Computed tomography of his legs showed no gas formation. Case 2 involved an 82‐year‐old man. He visited another hospital because of pain, redness, and swelling in the right thigh. Based on the X‐ray examination, necrotizing fasciitis was suspected, and he was transferred to our hospital. Results In Case 1, the regional oxygen saturation value was lower on the lesion side (41%) than on the healthy side (55%). We confirmed the depth of invasion by incision, leading to a diagnosis of necrotizing fasciitis. In Case 2, the thigh’s regional oxygen saturation was higher on the affected side (76%) than on the healthy side (61%). An incision was made for diagnosis, but the fascia was not necrotized. Thus, we diagnosed cellulitis and provided conservative treatment using antibiotics. Conclusion Near‐infrared spectroscopy can be utilized to measure tissue blood flow, and it could be useful as a non‐invasive diagnostic tool for skin and soft tissue infections.

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Effects of Hemoglobin Concentration, Skull Thickness, and the Area of the Cerebrospinal Fluid Layer on Near-infrared Spectroscopy Measurements

Abstract: rSO2 values were affected by hemoglobin concentration, a-CSFL, and t-skull, but TOI values were not affected by individual factors.

Cited by 153 publications

References 1 publication

Near-Infrared Spectroscopy can Monitor Dynamic Cerebral Autoregulation in Adults

Near-Infrared Spectroscopy can Monitor Dynamic Cerebral Autoregulation in Adults

Use of near‐infrared spectroscopy to identify trends in regional cerebral oxygen saturation in horses

Diagnosis of skin and soft tissue infections using near‐infrared spectroscopy

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